Serum ferritin as a crucial biomarker in the diagnosis and prognosis of intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease: A systematic review and meta-analysis

Wen, Haoran; Hun, Marady; Zhao, Ming; Han, Phanna; He, Qing

doi:10.3389/fmed.2022.941739

Cited by 7 publications

(3 citation statements)

References 49 publications

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“…Currently, an increasing number of studies are emerging regarding the diagnostic and prognostic value of PNI in various diseases. A previous meta-analysis investigated the value of PNI in the prognosis of cardiovascular diseases and showed that PNI can independently (17,33,34). In addition, neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been confirmed for their discriminative abilities to predict IVIGresistant KD patients in previous reports (35,36).…”

Section: Discussionmentioning

confidence: 95%

Values of prognostic nutritional index for predicting Kawasaki disease: a systematic review and meta-analysis

Zhong,

Xie,

Wang

et al. 2024

Front. Nutr.

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ObjectiveThis systematic review and meta-analysis aimed to evaluate the relationship between the prognostic nutritional index (PNI) and intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Kawasaki disease (KD).MethodsThe relevant literature was searched on PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar up to August 5, 2023. A pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC) were calculated to assess the predicted values of PNI in KD patients with IVIG resistance and CAL.ResultsA total of 8 articles containing 10 studies involving 7,047 participants were included. The pooled results revealed a pooled sensitivity of 0.44 (0.25–0.65), a pooled specificity of 0.87 (0.73–0.94), a pooled PLR of 3.4 (2.0–5.9), a pooled NLR of 0.65 (0.48–0.87), a pooled DOR of 5.26 (2.76–10.02), and a pooled AUC of 0.75 (0.71–0.78) in the diagnosis of KD with CAL. The pooled results suggested that a pooled sensitivity was 0.69 (0.60–0.77), specificity was 0.76 (0.69–0.82), PLR was 2.9 (2.1–4.1), NLR was 0.40 (0.29–0.56), DOR was 7.27 (3.89–13.59), and AUC was 0.79 (0.75–0.82) in the diagnosis of KD with IVIG resistance. The combined results revealed the pooled sensitivity was 0.63 (0.58–0.67), specificity was 0.82 (0.80–0.83), PLR was 3.09 (1.06–8.98), NLR was 0.38 (0.07–2.02), DOR was 8.23 (0.81–83.16) in differentiating KD from febrile patients. These findings demonstrated low sensitivity and relatively high specificity of PNI for KD, KD-CAL, and IVIG-resistant KD.ConclusionIn conclusion, this study was the first systematic review and meta-analysis of the diagnostic value of PNI in KD with IVIG resistance and CAL. The results suggested that PNI could be used as biomarkers for distinguish KD, KD with CAL, and KD with IVIG resistance.

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Section: Discussionmentioning

confidence: 95%

Values of prognostic nutritional index for predicting Kawasaki disease: a systematic review and meta-analysis

Zhong,

Xie,

Wang

et al. 2024

Front. Nutr.

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“…Vascular smooth muscle cells (VSMCs) in children with Kawasaki disease can increase ROS levels due to abnormal autophagy processes, activating corresponding cell death pathways and upregulating expression of NLRP3, to exacerbate mitochondrial dysfunction and vascular inflammation [ 217 ]. Studies revealed that serum iron levels are often reduced and serum ferritin levels are abnormally high in patients with KD, and these effects can be mediated by hepcidin treatment [ 218 , 219 ]. Through the combined action of various factors, VSMCs undergo iron overload and death, affecting vascular endothelial integrity.…”

Section: Relevant Clinical Diseasesmentioning

confidence: 99%

The crosstalk between mitochondrial quality control and metal-dependent cell death

Zhou,

Ren,

et al. 2024

Cell Death Dis

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Mitochondria are the centers of energy and material metabolism, and they also serve as the storage and dispatch hubs of metal ions. Damage to mitochondrial structure and function can cause abnormal levels and distribution of metal ions, leading to cell dysfunction and even death. For a long time, mitochondrial quality control pathways such as mitochondrial dynamics and mitophagy have been considered to inhibit metal-induced cell death. However, with the discovery of new metal-dependent cell death including ferroptosis and cuproptosis, increasing evidence shows that there is a complex relationship between mitochondrial quality control and metal-dependent cell death. This article reviews the latest research results and mechanisms of crosstalk between mitochondrial quality control and metal-dependent cell death in recent years, as well as their involvement in neurodegenerative diseases, tumors and other diseases, in order to provide new ideas for the research and treatment of related diseases.

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“…Patients with this condition experience acute febrile systemic vasculitis, in which their blood vessels become highly inflamed. Although it was already reported that sFT levels are elevated during Kawasaki disease [85], it was also recently shown that sFT may be used in the differential diagnosis between Kawasaki disease and other febrile pathologies, and also in the prognosis of coronary artery lesions in patients with this condition [86,87].…”

Section: Role Of Circulating Ferritin In Health and Diseasementioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

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The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

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Serum ferritin as a crucial biomarker in the diagnosis and prognosis of intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease: A systematic review and meta-analysis

Cited by 7 publications

References 49 publications

Values of prognostic nutritional index for predicting Kawasaki disease: a systematic review and meta-analysis

Values of prognostic nutritional index for predicting Kawasaki disease: a systematic review and meta-analysis

The crosstalk between mitochondrial quality control and metal-dependent cell death

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

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