Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer

Wang, Xijuan; An, Peng; Zeng, Jiling; Liu, Xiaoyan; Wang, Bo; Fang, Xuexian; Wang, Fudi; Ren, Guoping

doi:10.18632/oncotarget.14977

Cited by 24 publications

(24 citation statements)

References 37 publications

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“…Currently, the correlation between iron metabolism and tumor development has become a major concern (17,18). Numerous studies have revealed that the expression levels of ferritin are upregulated in various types of tumors, including lung cancer and prostate cancer (19). The present study demonstrated that the iron content and expression levels of ferritin were higher in HNSCC compared with normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

Wang

Han

et al. 2018

Oncol Lett

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, yet current treatment options are associated with limited success. The aim of the present study was to investigate the expression of ferritin in HNSCC and clarify whether it may serve as a biomarker for predicting HNSCC metastasis. The chemiluminescent immunoassay method was used to investigate the differences in the serum ferritin (SF) levels between patients with and without tumors, and between HNSCC with and without lymph node metastasis. The iron content and expression levels of ferritin were detected to verify the differences between tumor and normal tissues, and between HNSCC without and with lymph node metastasis. Data from the Gene Expression Omnibus (GEO) dataset was used to support the aforementioned results. No statistically significant difference in the SF level was observed between patients with and without tumors. Iron content and expression levels of ferritin heavy chain (FTH) and ferritin light chain (FTL) were higher in tumor tissues compared with normal tissues. The iron content and expression levels of SF, FTH and FTL were increased in HNSCC with metastasis compared with HNSCC without metastasis. The GEO dataset further verified the results and reported that the expression level of FTH was correlated with the prognosis of patients with HNSCC. Ferritin may not be a biomarker for the early diagnosis of HNSCC. However, an association exists between the expression level of ferritin and HNSCC cervical metastasis. SF may be a potential biomarker for predicting cervical lymph node metastasis in patients with HNSCC.

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Section: Discussionmentioning

confidence: 99%

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

Wang

Han

et al. 2018

Oncol Lett

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“…Clinical data with human patients show that iron dysmetabolism found in PCa cells is generally a local phenomenon not related to changes in systemic iron metabolism ( 90 , 98 ). Details from these studies suggest that systemic iron load might be associated with PCa in a subset of older patients with high levels of ferritin, though it is not known if high iron load in these cases is of primary importance or it has a secondary role by aggravating the already dysregulated iron metabolism found in PCa cells.…”

Section: Discussionmentioning

confidence: 99%

“…More contradictory data come from studies relating ferritin levels and its association with PCa. High and low levels of serum ferritin have been associated with PCa risk, while others have suggested no such association ( 96 , 98 – 100 ). The differences in patient numbers and selection between the studies might have been the reason behind these discrepancies.…”

Section: Systemic Iron Metabolism and Pcamentioning

confidence: 99%

“…Chua et al study (which reported no association between serum ferritin and PCa risk) included a relatively low number of patients with PCa, and also did not have any information about the cancer stage of the patients ( 99 ). In one of the largest studies (2002 patients) of this kind done by Wang et al, serum ferritin was shown to be a predictor of PCa risk ( 98 ). Close examination of the Wang et al study reveals that the differences in median values for serum ferritin though significant are still small.…”

Section: Systemic Iron Metabolism and Pcamentioning

confidence: 99%

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Iron Metabolism in Prostate Cancer; From Basic Science to New Therapeutic Strategies

Vela

2018

Front. Oncol.

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An increasing amount of research has recently strengthened the case for the existence of iron dysmetabolism in prostate cancer. It is characterized with a wide array of differential expression of iron-related proteins compared to normal cells. These proteins control iron entry, cellular iron distribution but also iron exit from prostate cells. Iron dysmetabolism is not an exclusive feature of prostate cancer cells, but it is observed in other cells of the tumor microenvironment. Disrupting the machinery that secures iron for prostate cancer cells can retard tumor growth and its invasive potential. This review unveils the current understanding of the ways that prostate cancer cells secure iron in the tumor milieu and how can we exploit this knowledge for therapeutic purposes.

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“…A central role in iron storage is carried out by ferritin. In some cases of cancer patients, ferritin is detected in high concentration in plasma, correlating with advanced tumor stage and poor outcome [27,28]. Accordingly, increased ferritin levels are found not only in inflammatory diseases, but also in several cancers (e.g., lung carcinoma, pancreatic, and colorectal cancer), suggesting that high ferritin might underlie cancer development and progression [29][30][31].…”

Section: Relationship Between Iron Metabolism and Cancermentioning

confidence: 99%

Iron Metabolism in Cancer Progression

Forciniti

Greco

Grizzi

et al. 2020

IJMS

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Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter, several disruptions of its metabolism occur at the steps of tumor initiation, progression and metastasis. Noticeably, cancer cells require a large amount of iron, and exhibit a strong dependence on it for their proliferation. Numerous iron metabolism-related proteins and signaling pathways are altered by iron in malignancies, displaying the pivotal role of iron in cancer. Iron homeostasis is regulated at several levels, from absorption by enterocytes to recycling by macrophages and storage in hepatocytes. Mutations in HFE gene alter iron homeostasis leading to hereditary hemochromatosis and to an increased cancer risk because the accumulation of iron induces oxidative DNA damage and free radical activity. Additionally, the iron capability to modulate immune responses is pivotal in cancer progression. Macrophages show an iron release phenotype and potentially deliver iron to cancer cells, resulting in tumor promotion. Overall, alterations in iron metabolism are among the metabolic and immunological hallmarks of cancer, and further studies are required to dissect how perturbations of this element relate to tumor development and progression.

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Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer

Cited by 24 publications

References 37 publications

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

Iron Metabolism in Prostate Cancer; From Basic Science to New Therapeutic Strategies

Iron Metabolism in Cancer Progression

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