Serum ferritin levels are associated with arterial stiffness in healthy Korean adults

Abstract

Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the association between ferritin and arterial stiffness in healthy adults. A total of 2932 healthy subjects were enrolled in this study. Anthropometric and biochemical profiles including ferritin were measured. The arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Serum ferritin levels were classified into quartiles and baPWV values gradually increased with each ferritin quartile. Multiple regression analysis showed that ferritin levels were independently correlated with baPWV. After adjusting for multiple risk factors, as compared with the lowest quartile, the odds ratios for high baPWV (>75(th) percentile) were 1.15 (0.84-1.56), 1.37 (0.97-1.73), and 1.46 (1.29-2.17) among men (p for trend < 0.05) and 1.24 (0.87-1.79), 1.53 (1.09-2.16), and 1.80 (1.25-2.82) among women (p for trend < 0.05), for the second, third, and fourth quartiles of ferritin, respectively. In conclusion, serum ferritin levels are independently associated with arterial stiffness in healthy Korean adults.

Ferritin modifies the relationship between inflammation and arterial stiffness in hypertensive patients with different glucose tolerance

“…However, there is growing evidence demonstrating a strong association between higher serum ferritin levels and functional vascular damage. According with this, Ha et al reported, in a large cohort of healthy subjects, an association between ferritin and brachial-ankle PWV [20]. Moreover in haemodialysis patients, serum ferritin was associated with progressive arterial stiffness increase during a 3 years follow-up, but only for serum values > 500 ng/ml [21].…”

“…A recent meta-analysis shows 8 hat 1 m/s increase in PWV is associated with a 15% risk increase of CV mortality in about 16,000 individuals followed up for a mean of 8 years [17]. Although there is some evidence of an independent association between hyperferritinemia and arterial stiffness in disparate populations [18][19][20][21], data in hypertensive patients are few.…”

Ferritin modifies the relationship between inflammation and arterial stiffness in hypertensive patients with different glucose tolerance

“…However, there is growing evidence demonstrating a strong association between higher serum ferritin levels and functional vascular damage. According with this, Ha et al reported, in a large cohort of healthy subjects, an association between ferritin and brachial-ankle PWV [20]. Moreover in haemodialysis patients, serum ferritin was associated with progressive arterial stiffness increase during a three years follow-up, but only for serum values >500 ng/ml (21).…”

“…Scienti c evidence has shown that high glucose levels also in the prediabetic range and insulin resistance might lead to increased arterial stiffness and cardiac concentric remodeling [27], moreover in a sample of hypertensive patients a signi cant positive association between baseline brachial-ankle PWV and the risk of new-onset diabetes was found [28]. Also serum ferritin levels have been associated with new-onset T2DM risk in Chinese [29] and Korean [30] populations and with increased arterial stiffness in healthy Korean adults [20]. Moreover, besides classical confounders, 24hours ambulatory BP and hs-CRP levels were determinants of pharmacologically (empagli ozin) induced improvement of arterial stiffness parameters [31].…”

“…A recent meta-analysis shows 8hat 1 m/s increase in PWV is associated with a 15% risk increase of CV mortality in about 16000 individuals followed up for a mean of 8 years [17]. Although there is some evidence of an independent association between hyperferritinemia and arterial stiffness in disparate populations [18][19][20][21], data in hypertensive patients are few.…”