Serum Ferritin Levels in Patients with Cervical Cancer

Ito, Hisao; Takagi, Yaeko; Ando, Yutaka; Kubo, Atsushi; Hashimoto, S; Tsutsui, F.; Kurihara, Sho

doi:10.1097/00006250-198003000-00018

Cited by 21 publications

(16 citation statements)

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“…In other words, it is not too difficult to discover early-stage cervical cancer and precancer. On the other hand, the extent of the disease, its positive response to treatment, and its recurrence are not easily determined [15]. Lymphangiography, angiography, magnetic resonance imaging, and computed tomography can be performed to identify lymph node metastasis and parame- Chen/Hsu/Lin/Tsai/Chang trial invasion, but these techniques provide only limited benefits [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Because therapy and prognosis differ according to the extent of the disease, it is important to determine the extent of the disease before treatment. Yet there are no available means of doing so other than by surgical exploration [15]. We assessed the relationship between clinical features, clinicopathologic variables, and lymph node metastasis (table 1, 2).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of p53 Expression in Stage IB1 Cervical Carcinoma

Chen

Hsu

Lin³

et al. 2000

Gynecol Obstet Invest

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The purpose of this retrospective study was to evaluate the patterns of p53 expression in stage IB1 squamous cell carcinoma of the uterine cervix, to compare p53 expression with clinicopathological findings, and to assess its prognostic value. 27 patients with stage IB1 squamous cell carcinoma of the uterine cervix underwent abdominal radical hysterectomy and pelvic lymph node dissection. Expression of p53 was studied immunohistochemically. Overexpression of p53 was detected in 33.3% of the tumors, low expression was seen in 11.1%, and negative expression was found in 55.6%. Deep cervical stromal invasion (≧1/2) was found to be associated with the increased risk of lymph node metastases (odds ratio = 17.5). A significantly lower percentage of patients survived when p53 overexpression was observed (p = 0.0315). Univariate analysis revealed that tumor size (2–3.9 cm), lymph node metastasis, tumor invasion into parametria, tumor invasion into blood/lymph vessels, squamous cell carcinoma antigen (≧2 ng/ml), and p53 overexpression had a significantly lower recurrence-free survival rate. None of these above factors obtained significance in the multivariate analysis. This study suggests that expression of p53 may be indicative of an unfavorable prognosis in patients with stage IB1 squamous cell carcinoma of the uterine cervix.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Value of p53 Expression in Stage IB1 Cervical Carcinoma

Chen

Hsu

Lin³

et al. 2000

Gynecol Obstet Invest

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“…In humans, the concentration of serum ferritin is increased in patients with various types of cancer 39–44 . Furthermore, in human patients with malignant histiocytic disease serum ferritin concentrations are markedly increased and the neoplastic cells stain positive for ferritin immunocytochemically 45,46 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs

Nielsen

McEvoy

Jessen

et al. 2011

Vet Comparative Oncology

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The aim of the study was to construct a screening programme for disseminated histiocytic sarcoma (DHS) in Bernese Mountain dogs using diagnostic imaging and blood analysis and evaluate blood borne biomarkers as early disease detection biomarkers. Healthy Bernese Mountain dogs were screened on four occasions in an attempt to detect early disease. Eleven blood borne biomarkers were examined for their worth as early tumour biomarkers. During 2.5 years, five dogs with early DHS were identified; four of these by diagnostic imaging. No dogs developed symptomatic DHS without being detected within 6 months of the screening programme. Only serum ferritin showed potential as a blood borne marker of the disease. Median survival times for the dogs with early DHS were 226 days. Screening programmes every 6 months for Bernese Mountain dogs over 4 years of age including diagnostic imaging and ferritin measurements may identify early DHS.

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“…악성 종양과 혈청 ferritin에 관한 기존의 연구들을 살 펴보면 유방암(7-10), 폐암 (11), 췌장암 (12), 자궁경부암 (13), 백혈병 (14), Hodgikin병 (15), 신경모세포종 (16), 두경 부암(17) 등 다양한 악성 종양에서 혈청 ferritin 수치의 증가가 보고되었다.…”

Section: 서 론unclassified

“…Ćujić 등의 연구에서는 (7) 조기 유방암 환자와 진행된 유방암 환자의 두 군 모두 정상 폐경 전 여성보다 ferritin 값이 증가되어 있었고 정상 대조군 250명과 조기 유방암 환자 229명의 ferritin 수치를 비교한 Jacobs의 연 구에서도 유방암 환자군이 정상 대조군보다 유의하게 ferritin 수치가 높았다 (18). 115명의 폐암 환자와 74명의 양성 폐질환 환자를 대상으로 한 연구에서 양성 폐질환 환자보다 폐암 환자의 혈청 ferritin 수치가 유의하게 높 았고 (11), Ito 등에 의해 진행된 ferritin과 자궁경부암과의 연구도 (13) Table 4).…”

Section: 서 론unclassified