2023
DOI: 10.1097/hep.0000000000000048
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Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia

Abstract: Background and Aims: Outcomes after Kasai portoenterostomy (KPE) for biliary atresia remain highly variable for unclear reasons. As reliable early biomarkers predicting KPE outcomes are lacking, we studied the prognostic value of FGF19. Approach and Results: Serum and liver specimens, obtained from biliary atresia patients (N=87) at KPE or age-matched cholestatic controls (N=26) were included. Serum concentration of FGF19 and bile acids, liver mRNA expression of FGF19, and key regulators of bile acid synthes… Show more

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Cited by 12 publications
(13 citation statements)
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“…While reasons for these reversed associations of FGF19 and bile acids require further investigations, they indicate differential regulation of DR in different stages of BA. Accordingly, serum matrix metalloproteinase 7 and cysteine-X cysteine motif chemocine ligand 8, which have been previously connected with the progression of DR following KPE, 25 , 26 showed more uniform and stronger correlations with CharBADR components during follow-up than at KPE.…”
Section: Discussionmentioning
confidence: 64%
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“…While reasons for these reversed associations of FGF19 and bile acids require further investigations, they indicate differential regulation of DR in different stages of BA. Accordingly, serum matrix metalloproteinase 7 and cysteine-X cysteine motif chemocine ligand 8, which have been previously connected with the progression of DR following KPE, 25 , 26 showed more uniform and stronger correlations with CharBADR components during follow-up than at KPE.…”
Section: Discussionmentioning
confidence: 64%
“…In line with our findings, a recent study linked high total serum bile acids measured at 6 months after successful KPE to decreased NLS and development of portal hypertension. 45 In another study, serum FGF19 measured at KPE predicted NLS with an association with DR. 25 Herein, CharBADR biliary components showed positive correlations with serum FGF19 at KPE, but not at post-KPE follow-up. While reasons for these reversed associations of FGF19 and bile acids require further investigations, they indicate differential regulation of DR in different stages of BA.…”
Section: Discussionmentioning
confidence: 73%
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“…The typical characteristics of advanced cirrhosis, such as decreased serum CA to CDCA ratios, decreased serum glycine-to-taurine-conjugated ratios, and elevated urinary total and primary bile acids, were not observed 10 12 . High bile acid levels in biliary atresia, even after normalization of bilirubin levels, have been attributed to the destruction of the small bile ducts 13 . Prolonged impairment of bile acid transport proteins, such as sodium-taurocholate cotransporting polypeptide (NTCP) and organic solute transporter (OST) α/β, could also explain why serum bile acid levels can remain elevated and fluctuate after the improvement of cholestasis 2 .…”
Section: Discussionmentioning
confidence: 99%
“…Although the study by Nyholm et al . 54 had a relatively large sample size, their serum and biopsy samples were stored for more than 14 years. The degradation of protein and mRNA may have affected the accuracy of the results.…”
Section: Fgf-19mentioning
confidence: 99%