Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients

Júnior, João Paulo Lobo; Brescansin, Catiane Pompilio; Santos-Weiss, Izabella Castilhos Ribeiro dos; Welter, Marciane; Souza, Emanuel Maltempi de; Rego, Fabiane Gomes de Moraes; Picheth, Geraldo; Alberton, Dayane

doi:10.1590/2359-3997000000238

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…A similar significant difference was found between the three groups for mean concentration of AGE with both the GDM and IGT groups having higher mean concentrations than the controls. The high CML and AGE levels in the GDM-diagnosed pregnancies supports similar results in previous studies ( 26 , 27 , 28 , 29 ).…”

Section: Discussionsupporting

confidence: 91%

Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy

Tanin¹,

Kara²,

Üstün³

et al. 2021

J Turkish German Gynecol Assoc

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Objective: The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation. Material and Methods: This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age. Results: The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p<0.001). Conclusion: In this study the use of AGEs, CML, and RAGE/AGER concentrations for the diagnosis and screening of gestational diabetes was investigated. It was found that advanced glycation products were significantly elevated in pregnancies with both IGT and GDM. These biochemical markers of glucose homeostasis dysregulation may have potential for GDM screening in the future.

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Section: Discussionsupporting

confidence: 91%

Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy

Tanin¹,

Kara²,

Üstün³

et al. 2021

J Turkish German Gynecol Assoc

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“…To address this, AGEs' assays are mostly based on the use of specific antibodies or spectrofluorimetric measurements based on the fluorescent properties of AGEs [212, 213]. Although promising results came from studies on skin autofluorescence in diabetic patients [214, 215], the serum fluorescence AGE (F-AGE) method did not distinguish women with gestational diabetes from the healthy controls [216]. …”

Section: Markers Based On Ros-induced Modificationsmentioning

confidence: 99%

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Marrocco

Altieri

Peluso

2017

Oxidative Medicine and Cellular Longevity

647

500

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Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants. We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans. There is a lack of consensus concerning the validation, standardization, and reproducibility of methods for the measurement of the following: (1) ROS in leukocytes and platelets by flow cytometry, (2) markers based on ROS-induced modifications of lipids, DNA, and proteins, (3) enzymatic players of redox status, and (4) total antioxidant capacity of human body fluids. It has been suggested that the bias of each method could be overcome by using indexes of oxidative stress that include more than one marker. However, the choice of the markers considered in the global index should be dictated by the aim of the study and its design, as well as by the clinical relevance in the selected subjects. In conclusion, the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.

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“…Regarding the geographical distribution, the review included seven studies from Europe [30][31][32][33][34][35][36], seven studies from Asia [37][38][39][40][41][42][43] and two studies from Latin America [44,45]. Thirteen of these studies employed case-control design [30,32,33,[35][36][37][38][39][40][41][42][43][44] whereas the rest three studies were cross-sectional in design [31,34,45]. Specifically, the meta-analysis of AGEs involved 774 cases and 834 controls.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The systematic review and meta-analysis involved studies that reported the outcome measures at both first and second trimesters [32], first and third trimesters [36], second trimester [30,31,34,41,44], second and third trimesters [38,42], and third trimester of pregnancy [33,35,37,39,40] whereas two studies did not specify gestational period during sample collection [43,45]. Blood sample was collected from 13 studies [30,31,33,[35][36][37][38][39][40][42][43][44][45], skin sample from two studies [32,34], and placenta sample from one study [41] ( Table 1). For analysis of specific AGEs and metabolic biomarkers, five and four studies were included to generate the pooled estimates of HOMA-IR [31,37,42,43,45], and HbA1c [31,33,37,43], respectively.…”

Section: Study Characteristicsmentioning

confidence: 99%

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

et al. 2020

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Introduction Gestational Diabetes Mellitus (GDM) is a condition in which women without history of diabetes experience hyperglycemia during pregnancy, especially at the second and third trimesters. In women who have had GDM, an elevated body mass index (BMI) may have a substantial impact for persistent hyperglycemia in their lives after gestation. Beyond hyperglycemia, increased local oxidative stress directly promotes the formation of Advanced Glycation End-products (AGEs). Hence, this systematic review and meta-analysis was aimed to determine the relationship between the level of AGEs and/or related metabolic biomarkers with GDM. Methods Literature search was carried out through visiting electronic databases, indexing services, and directories including PubMed/MEDLINE (Ovid ®), EMBASE (Ovid ®), google scholar and WorldCat to retrieve studies without time limit. Following screening and eligibility evaluation, relevant data were extracted from included studies and analyzed using Rev-Man 5.3 and STATA 15.0. Inverse variance method with random effects pooling model was used for the analysis of outcome measures at 95% confidence interval. Hedge's adjusted g statistics was applied to calculate the standardized mean difference (SMD) to consider the small sample bias. Besides, meta-regression, meta-influence, and publication bias analyses were conducted. The protocol has been registered on PROSPERO with ID: CRD42020173867. Results A total of 16 original studies were included for the systematic review and meta-analysis.

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Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients

Cited by 14 publications

References 27 publications

Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy

Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

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