Serum folate levels in bipolar disorder: a systematic review and meta-analysis

Hsieh, Yung-Chi; Chou, Li-Shiu; Lin, Ching‐Hua; Wu, Hung‐Chi; Li, Dian‐Jeng; Tseng, Ping‐Tao

doi:10.1186/s12888-019-2269-2

Cited by 17 publications

(11 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is growing interest in nutritional medicine in psychiatry and the relationship between nutrient deficiencies and psychiatric disorders ( Sarris et al, 2015 ). For example, folate is an essential nutrient obtained from the diet, and there is evidence of lower serum folate levels in individuals with BD and SZ ( Wang et al, 2016 ; Hsieh et al, 2019 ). Polymorphisms in the methylenetetrahydrofolate reductase ( MTHFR ) gene, a key enzyme in the folate cycle, may be partly driving this association in SZ ( Lewis et al, 2005 ; Yadav et al, 2016 ) and BD ( Peerbooms et al, 2011 ).…”

Section: Emerging Risk Factorsmentioning

confidence: 99%

Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions

Robinson

Bergen

2021

Front. Genet.

View full text Add to dashboard Cite

Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result from complex interplay between genetic and environmental factors. It is well-established that they are highly heritable disorders, and considerable progress has been made identifying their shared and distinct genetic risk factors. However, the 15–40% of risk that is derived from environmental sources is less definitively known. Environmental factors that have been repeatedly investigated and often associated with SZ include: obstetric complications, infections, winter or spring birth, migration, urban living, childhood adversity, and cannabis use. There is evidence that childhood adversity and some types of infections are also associated with BD. Evidence for other risk factors in BD is weaker due to fewer studies and often smaller sample sizes. Relatively few environmental exposures have ever been examined for SZ or BD, and additional ones likely remain to be discovered. A complete picture of how genetic and environmental risk factors confer risk for these disorders requires an understanding of how they interact. Early gene-by-environment interaction studies for both SZ and BD often involved candidate genes and were underpowered. Larger samples with genome-wide data and polygenic risk scores now offer enhanced prospects to reveal genetic interactions with environmental exposures that contribute to risk for these disorders. Overall, although some environmental risk factors have been identified for SZ, few have been for BD, and the extent to which these account for the total risk from environmental sources remains unknown. For both disorders, interactions between genetic and environmental risk factors are also not well understood and merit further investigation. Questions remain regarding the mechanisms by which risk factors exert their effects, and the ways in which environmental factors differ by sex. Concurrent investigations of environmental and genetic risk factors in SZ and BD are needed as we work toward a more comprehensive understanding of the ways in which these disorders arise.

show abstract

Section: Emerging Risk Factorsmentioning

confidence: 99%

Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions

Robinson

Bergen

2021

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Food nutrition is an important part of a daily diet and can have a profound effect on emotions, personalities, cognitive functioning, and moods. Bipolar disorder affects 5.7 million people or 2.6% of all people [41,24]. Many people diagnosed with bipolar disorder have rapid mood swings among other clinical symptomology.…”

Section: Nutrition and Bipolar Disordermentioning

confidence: 99%

“…People diagnosed with bipolar disorder are more likely to consume poorly prepared foods that are deficient in important vitamins, minerals, and omega-3 fatty acids [41] There are an estimated 200-400 suicides per 100,000 individuals with bipolar disorder each year [33]. According to the available studies, 20% or more people suffering from bipolar disorder (mainly untreated) take their own lives by suicide, and 20 to 60% make at least one attempt during their lifespan [48].…”

Section: Nutrition and Bipolar Disordermentioning

confidence: 99%

Nutritional Psychiatry Integrated Framework: Exploration of Nutrition and Co-occurring Bipolar Disorder and Post-traumatic Stress Disorder

Cuthrell¹

2022

INDJ

View full text Add to dashboard Cite

Nutritional psychiatry advancements are needed in understanding the effects of food nutrients on co-occurring psychiatric conditions particularly bipolar disorder and post-traumatic stress disorder (PTSD). Food nutrients contribute to the increase and decrease of symptoms in psychiatric conditions. Bipolar disorder and PTSD are frequently co-occurring and significantly impact moods, how the brain processes information, and psychological stressors. Individuals diagnosed with bipolar disorder and PTSD experience increased risks of suicide and are more likely to have unhealthy dietary habits. Understanding the appropriate nutrients to consume and avoid may contribute to promising outcomes for psychiatric conditions. Advancements in awareness of food nutrition are necessary to manage not only psychiatric conditions but also medical conditions. Omega-3 fatty acids, minerals (magnesium and zinc), pro-biotics, B vitamins, vitamins C and D, large neutral amino acids, specifically tryptophan and tyrosine, and branched-chained amino acids, antioxidants found in fruits and vegetables, and fatty acids have been linked to improved outcomes in the management of bipolar disorder and PTSD symptoms. Foods associated with poor prognosis have been linked to caffeine, alcohol, sugar, salt, processed foods, and artificial additives. This research contributes to the body of literature by exploring a link between food nutrients and bipolar disorder and PTSD because no known study has explored a co-occurring treatment intervention for such psychiatric conditions, and introduces the Nutritional Psychiatry Integrated Framework (NPIF)with a patient-centered focus which makes this research compelling. Advancements in understanding the effects of nutritional psychiatry associated with symptoms of bipolar disorder and PTSD may introduce innovative dietary and psychological treatment approaches.

show abstract

“…Serum folate levels are reduced in patients with BD as well ( Hsieh et al, 2019 ). Furthermore, BD patients may have elevated homocysteine levels during the manic episode ( Permoda-Osip et al, 2013 ).…”

Section: Vitamins and Their Role In Depressionmentioning

confidence: 99%

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

Aly

Engmann

2020

Front. Neurosci.

View full text Add to dashboard Cite

Globally, more than 250 million people are affected by depression (major depressive disorder; MDD), a serious and debilitating mental disorder. Currently available treatment options can have substantial side effects and take weeks to be fully effective. Therefore, it is important to find safe alternatives, which act more rapidly and in a larger number of patients. While much research on MDD focuses on chronic stress as a main risk factor, we here make a point of exploring dietary factors as a somewhat overlooked, yet highly promising approach towards novel antidepressant pathways. Deficiencies in various groups of nutrients often occur in patients with mental disorders. These include vitamins, especially members of the B-complex (B6, B9, B12). Moreover, an imbalance of fatty acids, such as omega-3 and omega-6, or an insufficient supply with minerals, including magnesium and zinc, are related to MDD. While some of them are relevant for the synthesis of monoamines, others play a crucial role in inflammation, neuroprotection and the synthesis of growth factors. Evidence suggests that when deficiencies return to normal, changes in mood and behavior can be, at least in some cases, achieved. Furthermore, supplementation with dietary factors (so called “nutraceuticals”) may improve MDD symptoms even in the absence of a deficiency. Non-vital dietary factors may affect MDD symptoms as well. For instance, the most commonly consumed psychostimulant caffeine may improve behavioral and molecular markers of MDD. The molecular structure of most dietary factors is well known. Hence, dietary factors may provide important molecular tools to study and potentially help treat MDD symptoms. Within this review, we will discuss the role of dietary factors in MDD risk and symptomology, and critically discuss how they might serve as auxiliary treatments or preventative options for MDD.

show abstract

Serum folate levels in bipolar disorder: a systematic review and meta-analysis

Cited by 17 publications

References 57 publications

Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions

Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions

Nutritional Psychiatry Integrated Framework: Exploration of Nutrition and Co-occurring Bipolar Disorder and Post-traumatic Stress Disorder

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

Contact Info

Product

Resources

About