Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis

Wang, Dan; Zhai, Jun-Xia; Liu, Dianwu

doi:10.1016/j.mce.2017.01.006

Cited by 23 publications

(18 citation statements)

References 24 publications

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“…Previous studies have shown lower folate levels and higher homocysteine levels in patients with T2D as compared with non-diabetic subjects [ 27 – 29 ]. A cohort study showed that dietary folate intake was inversely associated with risk of T2D for women, not for men [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Zhao

Yuan

et al. 2018

PLoS ONE

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Previous studies have shown that folate levels were decreased in patients with type 2 diabetes (T2D) and further lowered in T2D patients with cognitive impairment. However, whether folate deficiency could cause T2D and subsequent cognitive dysfunction is still unknown. The present study aimed to explore the effects of chronic folate deficiency (CFD) on glucose and lipid metabolism and cognitive function in mice. Seven-week-old mice were fed with either a CFD or control diet for 25 weeks. Serum folate was significantly reduced, whereas serum total homocysteine was significantly increased in the CFD group. Moreover, CFD induced obesity after a 6-week diet treatment, glucose intolerance and insulin resistance after a 16-week-diet treatment. In addition, CFD reduced the hepatic p-Akt/Akt ratio in response to acute insulin administration. Moreover, CFD increased serum triglyceride levels, upregulated hepatic Acc1 and Fasn mRNA expression, and downregulated hepatic Cd36 and ApoB mRNA expression. After a 24-week diet treatment, CFD induced anxiety-related activities and impairment of spatial learning and memory performance. This study demonstrates that folate deficiency could induce obesity, glucose and lipid metabolism disorders and subsequent cognitive dysfunction.

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Section: Discussionmentioning

confidence: 99%

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Zhao

Yuan

et al. 2018

PLoS ONE

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“…Vitamin B12 status has been linked to several neurological disorders, including neuropathy and myelopathy, as well as several brain disorders [ 33 ]. Folic acid is another B vitamin associated with neuron growth whose deficiency may increase risk for peripheral neuropathy [ 34 ]. In a secondary analysis, we found a significant association between tertile of cold cereal consumption and change in neuropathy symptoms (chi-square p = 0.01; data not shown).…”

Section: Discussionmentioning

confidence: 99%

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

et al. 2018

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BackgroundThe pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment.MethodsWomen with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10–30%, > 30%) (n = 900).ResultsThe odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66–0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01–1.40, p = 0.05).ConclusionsDistinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer.Trial registrationClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.

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“…In 2016, Cao et al [ 34 ] conducted a meta-analysis of 20 eligible studies and found that lower folate level may be related to the risk of schizophrenia. In 2017, the meta-analysis data reported by Wang et al [ 35 ] showed the correlation between reduced serum levels of folate and vitamin B 12 and the risk of type 2 diabetes mellitus in a Chinese population. The low level of folate was also reported to be linked to the risk of inflammatory bowel disease but that of vitamin B 12 was not [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Colorectal polyp risk is linked to an elevated level of homocysteine

Sun

Zhang

et al. 2018

Bioscience Reports

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Several studies have reported an association between levels of folate, homocysteine, and vitamin B12 and the risk of colorectal polyps. Here, our aim is to examine the possible effect of folate, homocysteine, and vitamin B12 levels on the risk of colorectal polyps by means of meta-analysis based quantitative synthesis. According to our inclusion/exclusion criteria, a total of 13 case–control studies were enrolled. The P-value of the association test, standard mean difference (SMD), and 95% confidence interval (CI) were calculated. Pooled analysis data showed a negative correlation between the risk of colorectal polyps and the levels of serum folate, red blood cell (RBC) folate, or vitamin B12 (all P>0.05). Nevertheless, for homocysteine level, we also observed a statistically significant difference between cases and controls in the overall and subgroup analysis of hospital-based control (HB), population-based control (PB), Chinese, Caucasian, or Asian (all P<0.05, SMD > 0). We found that increased levels of homocysteine may be statistically and significantly related to the risk of colorectal polyps.

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Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis

Cited by 23 publications

References 24 publications

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

Colorectal polyp risk is linked to an elevated level of homocysteine

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