Serum fructosamine as a marker of 5‐year risk of developing diabetes mellitus in patients exhibiting stress hyperglycaemia

Wahid, S. T.; Sultan, Javed; Handley, G; Saeed, B. O.; Weaver, Jolanta U.; Robinson, A. C. J.

doi:10.1046/j.1464-5491.2002.00730.x

Cited by 12 publications

(7 citation statements)

References 36 publications

(37 reference statements)

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“…Both antibodies were purified from cell lines provided by Dr. O'Connor (Columbia University, New York, NY). B152 was biotinylated with long-chain NHS-biotin (13 ), and B207 was conjugated with acridinium ester (14 ).…”

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confidence: 99%

Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay

et al. 2003

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confidence: 99%

Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay

et al. 2003

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“…With regards to blood glucose levels, studies in humans have shown that stress-induced hyperglycemia correlates with subsequent development of diabetes and that the subjects who were predisposed to develop glucose intolerance during the FSIVGTT had higher fructosamine levels at baseline. [ 70 ] As mentioned above, the IR pigs appeared to exhibit stress-associated hyperglycemia during the Bergman FSIVGTT that may have accounted for some portion of the higher fructosamine levels. Fructosamine has also been shown to correlate with 2 hr postprandial glucose[ 71 ] and relatively short periods of hyperglycemia have been shown to increase protein glycation even if fasting glucose is not increased.…”

Section: Discussionmentioning

confidence: 98%

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet

et al. 2015

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BackgroundInsulin-resistant subjects develop more severe and diffuse coronary artery atherosclerosis than insulin-sensitive controls but the mechanisms that mediate this atherosclerosis phenotype are unknown.Research ObjectiveTo determine the metabolic parameters that associate with the severity of coronary atherosclerosis in insulin resistant pigs fed a high fat/high NaCl diet.Key MethodsThe primary endpoint was severity of coronary atherosclerosis in adult pigs (Sus scrofa, n = 37) fed a high fat diet that also contained high NaCl (56% above recommended levels) for 1 year.Principal FindingsTwenty pigs developed severe and diffuse distal coronary artery atherosclerosis (i.e., severe = intimal area as a percent medial area > 200% in at least 2 coronary artery cross sections and diffuse distal = intimal area as a percent medial area ≥ 150% over 3 sections separated by 2 cm in the distal half of the coronary artery). The other 17 pigs had substantially less coronary artery atherosclerosis. All 37 pigs had blood pressure in a range that would be considered hypertensive in humans and developed elevations in total and LDL and HDL cholesterol, weight gain, increased backfat, and increased insulin resistance (Bergman Si) without overt diabetes. Insulin resistance was not associated with atherosclerosis severity. Five additional pigs fed regular pig chow also developed increased insulin resistance but essentially no change in the other variables and little to no detectible coronary atherosclerosis. Most importantly, the 20 high fat/high NaCl diet -fed pigs with severe and diffuse distal coronary artery atherosclerosis had substantially greater increases (p< 0.05) in oxidized LDL (oxLDL) and fructosamine consistent with increased protein glycation.ConclusionIn pigs fed a high fat/high NaCl diet, glycated proteins are induced in the absence of overt diabetes and this degree of increase is associated with the development of severe and diffuse distal coronary artery atherosclerosis.

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“…It is also important to note that a conclusion regarding the unsuitability of these markers for assessing variation in glycemic exposures in individuals without diabetes is not an assessment of their potential value as markers of disease risk in this population. Variation in each of these markers has been reported to be significantly associated with future risk of diabetes or cardiovascular disease in populations without diabetes ( 68 , 113 , 114 ).…”

Section: Discussionmentioning

confidence: 99%

Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes

Feskens

Brennan

Dussort

et al. 2020

Advances in Nutrition

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There is considerable interest in dietary and other approaches to maintaining blood glucose concentrations within the normal range and minimizing exposure to postprandial hyperglycemic excursions. The accepted marker to evaluate the sustained maintenance of normal blood glucose concentrations is glycated hemoglobin A1c (HbA1c). However, although this is used in clinical practice to monitor glycemic control in patients with diabetes, it has a number of drawbacks as a marker of efficacy of dietary interventions that might beneficially affect glycemic control in people without diabetes. Other markers that reflect shorter-term glycemic exposures have been studied and proposed, but consensus on the use and relevance of these markers is lacking. We have carried out a systematic search for studies that have tested the responsiveness of 6 possible alternatives to HbA1c as markers of sustained variation in glycemic exposures and thus their potential applicability for use in dietary intervention trials in subjects without diabetes: 1,5-anhydroglucitol (1,5-AG), dicarbonyl stress, fructosamine, glycated albumin (GA), advanced glycated end products (AGEs), and metabolomic profiles. The results suggest that GA may be the most promising for this purpose, but values may be confounded by effects of fat mass. 1,5-AG and fructosamine are probably not sensitive enough to the range of variation in glycemic exposures observed in healthy individuals. Use of measures based on dicarbonyls, AGEs, or metabolomic profiles would require further research into possible specific molecular species of interest. At present, none of the markers considered here is sufficiently validated and sensitive for routine use in substantiating the effects of sustained variation in dietary glycemic exposures in people without diabetes.

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Serum fructosamine as a marker of 5‐year risk of developing diabetes mellitus in patients exhibiting stress hyperglycaemia

Abstract: The level of RSG in stress hyperglycaemia does not predict the future development of DM. Raised serum fructosamine is a more useful marker of future DM risk than RSG alone. Further prospective studies are needed.

Cited by 12 publications

References 36 publications

Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay

Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet

Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes

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