Serum fructosamine in diabetic pregnancy.

Frandsen, Erik; Sabagh, T. O.; Bacchus, Robby

doi:10.1093/clinchem/34.2.309

Cited by 13 publications

(4 citation statements)

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“…However, fructosamine was insensitive for identifying GDM in early pregnancy [293] . Therefore, fructosamine may be a good biomarker to predict neonatal outcomes and maternal glycemia but additional studies are needed to establish suitable reference ranges [293][294][295][296][297].…”

Section: Fructosaminementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

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Highlights A 1-hour plasma glucose (1-h PG) threshold >155 mg/dl (8.6 mmol/L) during an oral glucose tolerance test (OGTT) may be a suitable biomarker for identifying normal glucose tolerant (NGT) individuals at risk for future type 2 diabetes (T2D). A one-hour, non-fasting, 50g Glucose Challenge Test (GCT) performed during a routine health care visit has potential for practical screening of glucose disorders. The shape of the glucose curve reflects the cumulative effect of insulin sensitivity and response on glucose concentrations with prospective studies warranted to evaluate its prognostic utility. The continuous glucose monitor (CGM) has facilitated insight into the pathophysiology of prediabetes and phenotypes of T2D and holds promise for detecting glycemic disorders. Metabolomic profiling including amino acids, lipids, carbohydrates and other metabolites may be useful for early diagnosis of glycemic disorders. Non-classical markers for assessing glycemic disorders including fructosamine, glycated albumin, and 1,5-anhydroglucitol that evaluate shorter periods of glucose exposure than HbA1c have potential use as adjunctive tools.

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Section: Fructosaminementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

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“…Serum fructosamine levels are correlated with maternal and gestational age and this complicates fructosamine utility for screening or diagnosing diabetic pregnancy, 73,74 so that specific reference ranges should be established throughout pregnancy to increase its diagnostic efficiency.…”

Section: Glycated Albumin and Fructosamine In Gestational Diabetes Mementioning

confidence: 99%

Advantages and Pitfalls of Fructosamine and Glycated Albumin in the Diagnosis and Treatment of Diabetes

Danese

Montagnana

Nouvenne

et al. 2015

J Diabetes Sci Technol

167

139

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Diabetes is one of the most severe and frequent human disorders. According to recent statistics, this condition afflicts as many as 382 million persons around the globe, with an estimated prevalence of approximately 8.3% in 2013. At variance with other frequent pathologies such as cardiovascular disease and bacterial infections, the trend toward an increased prevalence is not expected to soon reverse. Worldwide, as many as 592 million individuals may be affected by diabetes in 2035, a remarkable 55% increase in prevalence over the next 2 decades. 1 Due to its high global prevalence and severe, frequently life-threatening complications (eg, retinopathy, nephropathy, neuropathy, cardiovascular disease), diabetes must be regarded as a serious and increasing global health burden. The most recent Standards of Medical Care in Diabetes published by the American Diabetes Association (ADA) emphasize that early diagnosis and monitoring are critical for preventing or delaying the onset of acute complications and lowering the risk of long-term complications of diabetes. 2 The current diagnostic criteria for this condition are based on the presence of (1) glycated hemoglobin (HbA1c) value ≥6.5% (ie, ≥48 mmol/mol), (2) fasting plasma glucose (FPG) ≥126 mg/dL (ie, ≥7.0 mmol/L), (3) 2-hour plasma glucose ≥200 mg/dL (ie, ≥11.1 mmol/L) during an oral glucose tolerance test (OGTT) using a 75 g glucose load, or (4) random plasma glucose ≥200 mg/dL (ie, ≥11.1 mmol/L). An increased risk of diabetes (ie, prediabetes) is defined in the presence of (1) HbA1c value between 5.7-6.4% (ie, 39-46 mmol/mol), (2) FPG between 100-126 mg/dL (ie, 5.6-6.9 mmol/L), (3) 2-hour plasma glucose between 140-199 mg/ dL (ie, 7.8-11.0 mmol/L) during an OGTT. With regard to diabetes monitoring, the glycemic targets for nonpregnant adults with diabetes include HbA1c value <7.0% (ie, <53 mmol/mol), preprandial capillary plasma glucose between 567227D STXXX10.

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“…Measurement of the glycosylated hemoglobin concentration is an accepted method for assessing long-term diabetic control, 19 , 20 ) Many studies reported that fructosamine, as an index of short-term diabetic control, correlated with HbAlc and other measures of glycemia and appeared more useful than HbAlc for monitoring short-term changes. 1 , 10 – 15 , 17 ) Other previous reports showed that the fasting plasma glucose concentration varies in response to stress or exercise, urinary glucose is modified by the renal threshold, the HbAlc value depends on red cell turnover and fructosamine is influenced by alterations in serum protein metabolism. 1 , 10 )…”

Section: Discussionmentioning

confidence: 99%

“…Since the measurement of fructosamine as an index of diabetic control was first published by Johnson (1982), 12 ) Baker et 1 ) al., 10 , 13 ) Jerntorp et al 11 ) and other investigators 14 , 15 , 17 ) have reported that fructosamine concentrations were correlated with HbAlc and other measures of glycemia, and fructosamine appeared more useful than HbAlc for monitoring short-term changes of glycemia.…”

Section: Introductionmentioning

confidence: 95%

The Clinical Usefulness of Serum Fructosamine and HbAlc in Patients with MIDDM

Lim¹,

Jhoo²,

Lee³

et al. 1989

Korean J Intern Med

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To evaluate the clinical values of serum fructosamine and HbAlc, serum fructosamine and HbAlc were assessed in 50 normal controls and 36 patients with NIDDM (non-insulin-dependent diabetes mellitus). And we studied 10 patients selected at random among the 36 patients with NIDDM.The values of serum fructosamine and HbAlc in controls were 2.1 mmol/L and 5.3%, respectively. The levels of serum fructosamine and HbAlc were significantly higher in NIDDM patients (3.27 mmol/L and 8.8%, respectively, p<0.005) compared with those in the controls. The serum fructosamine was significantly correlated with fasting plasma glucose and HbAlc (r=0.78, p<0.78, p<0.001; r=0.76, p<0.005, respectively). Also, in retrograde study, serum fructosamine concentration had a significant correlation to fasting plasma glucose determined 2 weeks before (r=0.72, p<0.002), and 4 weeks before (r=0.54, p<0.005).It is concluded that serum fructosamine measurement may be useful in monitoring short-term control of plasma glucose in patients with NIDDM.

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Serum fructosamine in diabetic pregnancy.

Cited by 13 publications

References 0 publications

Review of methods for detecting glycemic disorders

Review of methods for detecting glycemic disorders

Advantages and Pitfalls of Fructosamine and Glycated Albumin in the Diagnosis and Treatment of Diabetes

The Clinical Usefulness of Serum Fructosamine and HbAlc in Patients with MIDDM

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