Serum gamma-glutamyltransferase is associated with future risk of psychosis - A prospective cohort study

Kunutsor, Setor K; Laukkanen, Jari A.

doi:10.1016/j.schres.2016.10.025

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Another factor that has more recently been implicated is γ-glutamyl transferase (GGT), usually used as a marker of liver damage, but now linked to oxidative stress and the inflammatory pathways thought to underlie psychosis. However, it is currently unclear whether this is involved in pathogenesis or is simply a marker of inflammatory pathology (Kunutsor 2017).…”

Section: Pathway 3: Inflammationmentioning

confidence: 99%

The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies

et al. 2019

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SUMMARYPsychosis is a recognised feature of several psychiatric disorders and it causes patients significant distress and morbidity. It is therefore important to keep knowledge of possible risk factors for psychosis up to date and to have an overview model on which further learning can be structured. This article concludes a three-part series. It gives a review of evidence regarding common pathways by which many risk factors come together to influence the development of psychosis and finalises our suggested overview model, a psychosis risk timeline. The three primary pathways considered are based on the major themes identified in this narrative review of recent literature and they focus on neurological, neurochemical and inflammatory changes. We link each back to the factors discussed in the first and second parts of this series that alter psychosis risk through different mechanisms and at different stages throughout life. We then consider and summarise key aspects of this complex topic with the aim of providing current and future clinicians with a model on which to build their knowledge and begin to access and understand current psychosis research and implications for future preventive work.LEARNING OBJECTIVESAfter reading this article you will be able to: •give an overview of common pathways thought to link identified risk factors with psychosis development•understand neurochemical, neurostructural and inflammatory changes associated with psychosis•demonstrate increased knowledge of possible preventive strategies.DECLARATION OF INTERESTNone.

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Section: Pathway 3: Inflammationmentioning

confidence: 99%

The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies

et al. 2019

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“…Gamma-glutamyltransferase (GGT), commonly used as a marker for excessive alcohol consumption [3] and an index of liver injury, has been consistently shown to be positively and independently linked with the future risk of adverse vascular and non-vascular outcomes. [4,5] Gamma-glutamyltransferase is a marker of oxidative stress [6] and has pro-inflammatory properties [7] and has been suggested to be involved in the pathogenesis of these adverse outcomes via pro-oxidant and inflammatory pathways.…”

Section: Introductionmentioning

confidence: 99%

Gamma-Glutamyltransferase and Future Risk of Pneumonia: A Long-Term Prospective Cohort Study

Kunutsor

Laukkanen

2017

Lung

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Serum gamma-glutamyltransferase (GGT) has been linked with the risk of adverse health outcomes. We aimed to assess the prospective association of GGT activity with pneumonia risk. Serum GGT was measured at baseline in 2400 middle-aged men. Within-person variability in GGT values was corrected for using data from repeat measurements. During a median follow-up of 25.3 years, 409 pneumonia cases were recorded. The age-adjusted regression dilution ratio of GGT was 0.68 (95% CI 0.63-0.73). Gamma-glutamyltransferase was approximately log-linearly associated with pneumonia risk. In analysis adjusted for several major pneumonia risk factors, the hazard ratio (95% CI) for pneumonia per 1 standard deviation increase in GGT was 1.14 (1.02-1.28). The association was however attenuated on additional adjustment for high-sensitivity C-reactive protein (hsCRP) 1.08 (0.96-1.22). There is an approximately log-linear positive association between GGT activity and future risk of pneumonia in a middle-aged male population, which is partly dependent on hsCRP.

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Exercise and Schizophrenia

Bueno‐Antequera

2020

Advances in Experimental Medicine and Biology

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Serum gamma-glutamyltransferase is associated with future risk of psychosis - A prospective cohort study

Cited by 4 publications

References 10 publications

The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies

The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies

Gamma-Glutamyltransferase and Future Risk of Pneumonia: A Long-Term Prospective Cohort Study

Exercise and Schizophrenia

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