Serum gastrin and pepsinogens do not correlate with the different grades of severity of gastro‐oesophageal reflux disease: a matched case–control study

Mönkemüller, Klaus; Neumann, Helmut; Nocon, Marc; Labenz, Joachim; Willich, Stefan N.; Stolte, Manfred; Höcker, Michael; Jaspersen, D; Lind, Tore; Malfertheiner, Peter

doi:10.1111/j.1365-2036.2008.03769.x

Cited by 17 publications

(17 citation statements)

References 34 publications

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“…In our study, we observed neither a change in the gastrin level nor in GERD occurrence between H. pylori-infected and non-infected state. In contrast to these hypotheses, we could not demonstrate any relationship between gastrin and GERD, which was comparable with a few studies in the literature (18)(19)(20)(21)(22)(23)(24). One of the reasons for this difference can be the predominant corpoantral infection in our patients.…”

Section: Discussioncontrasting

confidence: 56%

Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Eren

Çolak²,

Işıksoy³

et al. 2015

Turk J Gastroenterol

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Background/Aims: To evaluate the occurrence of gastroesophageal reflux and possible mechanisms in Helicobacter pylori infection. Materials and Methods: Symptoms of H. pylori-infected children, their total gastroesophageal reflux episodes, acid exposure percentage, gastrin, ghrelin, and motilin levels were evaluated before and after H. pylori eradication. Results: Forty-two H. pylori-infected children were eligible for this study. Acid exposure % and total reflux episodes before and after H. pylori eradication were 10.2%±14.8% vs. 7.71%±5.0% and 94.7%±102.1% vs. 64.6%±55.0%, respectively (p=0.28, p=0.082). There was an insignificant change in the serum gastrin (93.4±153.8 pmol/L vs. 1.28±149.4 pmol/L, p=0.67), ghrelin (7.69±197.5 pg/mL vs. 8.36±299.5 pg/mL, p=0.274), and motilin (75.1±81.2 pg/mL vs. 97.2±80.5 pg/mL, p=0.206) levels after eradication. Gastrin and ghrelin levels were negatively correlated after H. pylori eradication (r=−0.38, p=0.031). There was no association between gastroesophageal reflux episodes and gastrin, ghrelin, and motilin levels (r=0.25 and p=0.11; r= 0.24 and p=0.13; r=-0.23 and p=0.14, respectively) Conclusion: H. pylori infection is neither protective nor harmful in the gastroesophageal reflux. Neither ghrelin nor motilin levels was associated with gastroesophageal reflux. None of gastrin, ghrelin, and motilin levels was affected by H. pylori infection. There is an inverse association between gastrin and ghrelin levels after H. pylori eradication.

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Section: Discussioncontrasting

confidence: 56%

Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Eren

Çolak²,

Işıksoy³

et al. 2015

Turk J Gastroenterol

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“…Thus, it would be intriguing to predict the development of reflux esophagitis after H. pylori eradication on the basis of the serum PG I level. Nonetheless, two recent reports [48,49], one of which is our own [48], on the correlation between PG levels and the grades of gastro-esophageal reflux disease are conflicting; we have reported that serum PG I levels are elevated in long-segment Barrett's esophagus compared with controls [48], while Monkemuller et al [49] reported that serum PGs do not correlate with the different grades of severity of GERD. Further studies are required to investigate the correlation between serum PG levels and the occurrence of reflux esophagitis after eradication.…”

Section: Discussionmentioning

confidence: 81%

Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication

et al. 2009

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“…On the other hand, association of NERD with H. pylori infection or atrophic gastritis is still controversial[33],[36]–[38]. As H. pylori infection is significantly associated with both RE and NERD in the present study (Table 2 and 4), we further analyzed the effects of H. pylori eradication on GERD patients.…”

Section: Resultsmentioning

confidence: 87%

Background Factors of Reflux Esophagitis and Non-Erosive Reflux Disease: A Cross-Sectional Study of 10,837 Subjects in Japan

et al. 2013

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BackgroundDespite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stomach. Our aim is therefore to define background factors of RE and NERD independently, based on the evaluation of Helicobacter pylori infection and gastric atrophy.MethodsWe analyzed 10,837 healthy Japanese subjects (6,332 men and 4,505 women, aged 20–87 years) who underwent upper gastrointestinal endoscopy. RE was diagnosed as the presence of mucosal break, and NERD was diagnosed as the presence of heartburn and/or acid regurgitation in RE-free subjects. Using GERD-free subjects as control, background factors for RE and NERD were separately analyzed using logistic regression to evaluate standardized coefficients (SC), odds ratio (OR), and p-value.ResultsOf the 10,837 study subjects, we diagnosed 733 (6.8%) as RE and 1,722 (15.9%) as NERD. For RE, male gender (SC = 0.557, OR = 1.75), HP non-infection (SC = 0.552, OR = 1.74), higher pepsinogen I/II ratio (SC = 0.496, OR = 1.64), higher BMI (SC = 0.464, OR = 1.60), alcohol drinking (SC = 0.161, OR = 1.17), older age (SC = 0.148, OR = 1.16), and smoking (SC = 0.129, OR = 1.14) are positively correlated factors. For NERD, HP infection (SC = 0.106, OR = 1.11), female gender (SC = 0.099, OR = 1.10), younger age (SC = 0.099, OR = 1.10), higher pepsinogen I/II ratio (SC = 0.099, OR = 1.10), smoking (SC = 0.080, OR = 1.08), higher BMI (SC = 0.078, OR = 1.08), and alcohol drinking (SC = 0.076, OR = 1.08) are positively correlated factors. Prevalence of RE in subjects with chronic HP infection and successful HP eradication denotes significant difference (2.3% and 8.8%; p<0.0001), whereas that of NERD shows no difference (18.2% and 20.8%; p = 0.064).ConclusionsSignificantly associated factors of NERD are considerably different from those of RE, indicating that these two disorders are pathophysiologically distinct. Eradication of Helicobacter pylori may have disadvantageous effects on RE but not on NERD.

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Serum gastrin and pepsinogens do not correlate with the different grades of severity of gastro‐oesophageal reflux disease: a matched case–control study

Abstract: SUMMARY BackgroundGastrin and pepsinogens reflect the functional state of the gastric mucosa.

Cited by 17 publications

References 34 publications

Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication

Background Factors of Reflux Esophagitis and Non-Erosive Reflux Disease: A Cross-Sectional Study of 10,837 Subjects in Japan

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