Serum growth differentiation factor-15 levels are associated with the severity of diabetic foot ulcer

Şendur, Süleyman Nahit; Firlatan, Busra; Baykal, Gokhan; Lay, İncilay; Erbaş, Tomris

doi:10.1007/s42000-022-00408-4

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…This last point is in contrast to other data on this risk factor (14,29), although our population has a maximum age of 55 years, and so excludes the elderly who are more likely to carry a greater burden of disease. As both genes and their products are altered in diabetics without cardiovascular disease (30)(31)(32), we note that this risk factor does not have a modulating effect on gene expression on a platform of acute coronary artery disease, although some have reported increases in those disease with more extensive disease (32)(33)(34). However, the precise clinical science of our data is clouded by the use of metformin by over a third of our patients with diabetes, as this drug has a positive in uence on circulating GDF-15 (35).…”

Section: Discussionmentioning

confidence: 94%

A pilot study of increased gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in the middle-aged with acute coronary artery disease

Abdelsabour,

Idriss,

Blann

et al. 2023

Preprint

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Introduction: Growth Differentiation Factor 15 (GDF15) and Telomerase Reverse Transcriptase (TERT) may have roles as serum biomarkers of the pathophysiology of cardiovascular disease. We hypothesised altered genomic expression of the genes for these molecules in middle aged subjects with acute coronary artery disease. Method: Venous blood was obtained from 53 patients (27 with diabetes) presenting with an acute coronary syndrome and subsequently shown to have coronary artery disease (CAD), and from 46 age and sex matched controls free of cardiovascular disease and its risk factors. Relative expression of leukocyte transcriptome GAPDH, GDF15and TERT were determined by RT-PCR and quantified by quantitation-comparative Ct (ΔΔCt). Results: Compared to expression in controls, mean (95% confidence interval) relative expression of GDF15in the patients was 1.38 (1.13-1.49) (p<0.001), and of TERT was 1.12 (1.04-1.20) p=0.003), with relative expression of GDF15 being greater than that of TERT (p<0.001). Expression of the two genes failed to correlate significantly in the controls (r=0.22, p=0.131) but did so in the patients (r=0.55, p<0.01). There was no difference in relative expression of GDF15 in 26 patients free of diabetes (1.6 [1.42-1.78]) compared to those 27 with diabetes (1.6 [1.29-1.91]) (p=0.996). Similarly, there was no difference in the expression of TERT in patients free of diabetes (1.19 [1.06-1.33]) compared to those with diabetes (1.25 [0.98-1.50]) (p=0.739). Conclusion: Relative expression of GDF15 and TERTare both increased in middle-aged patients with CAD and in CAD+diabetes, with no difference between the patient groups. These genes may have roles in the pathogenesis of acute coronary artery disease.

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Section: Discussionmentioning

confidence: 94%

A pilot study of increased gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in the middle-aged with acute coronary artery disease

Abdelsabour,

Idriss,

Blann

et al. 2023

Preprint

View full text Add to dashboard Cite

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Genetics of hyperaldosteronism and a wealth of new information on topics ranging from MEN1 to Cushing’s disease and metabolic syndrome

Stratakis

2022

Hormones

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Diagnostic value of the gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in middle-aged patients with acute coronary artery disease: a pilot case-control study

Abdelsabour,

Idriss,

Blann

et al. 2024

Preprint

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Background: Differential diagnosis of the various manifestations of ischaemic heart disease can be difficult, especially in the young, with many investigations being relevant. We hypothesised that expression of the genes for Growth Differentiation Factor 15 (GDF15) and Telomerase Reverse Transcriptase (TERT) have a place in the diagnosis of an acute coronary artery disease event in those aged up to 55 years with existing coronary artery disease. Venous blood was obtained from 53 patients (27 with diabetes) presenting with an acute coronary syndrome and subsequently shown to have coronary artery disease, and from 46 age and sex matched controls free of cardiovascular disease and its risk factors. Relative expression of leukocyte transcriptome GAPDH, GDF15 and TERTwere determined by real-time polymerase chain reaction and quantified by quantitation-comparative Ct (ΔCt). Results: Compared to controls, mean (95% CI) relative expression of GDF15 mRNA in the patients was 1.38 (1.13-1.49) (p<0.001), and of TERT was 1.12 (1.04-1.20) p=0.003), with GDF15 being greater than that of TERT(p<0.001). There was no difference in relative GDF15 expression in 26 patients free of diabetes (1.6 [1.42-1.78]) versus the 27 patients with diabetes (1.6 [1.29-1.91]) (p=0.996), and no difference in relative TERTexpression in patients free of diabetes (1.19 [1.06-1.33]) compared to those with diabetes (1.25 [0.98-1.50]) (p=0.739). Conclusions: Compared to healthy controls, GDF15 and TERT expressions are both increased in coronary artery disease and in coronary artery disease+diabetes, with no difference between the patient groups. These genes may have roles in the diagnosis and pathogenesis of acute coronary artery disease.

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Serum growth differentiation factor-15 levels are associated with the severity of diabetic foot ulcer

Cited by 4 publications

References 38 publications

A pilot study of increased gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in the middle-aged with acute coronary artery disease

A pilot study of increased gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in the middle-aged with acute coronary artery disease

Genetics of hyperaldosteronism and a wealth of new information on topics ranging from MEN1 to Cushing’s disease and metabolic syndrome

Diagnostic value of the gene expression of Growth Differentiation Factor 15 and Telomerase Reverse Transcriptase in middle-aged patients with acute coronary artery disease: a pilot case-control study

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