Serum Haptoglobins in Megaloblastic Anaemia

Serum Haptoglobins in Haemolytic States

“…The finding (Table V) of a negative correlation between haemoglobin destruction and serum haptoglobin supports this view, as does the negative correlation between serum bilirubin and haptoglobin levels observed in this investigation and in a previous study (Owen et al, 1960b). Correlations between serum haptoglobin levels and faecal urobilinogen and endogenous blood carbon monoxide respectively (Nyman et al, 1959) add additional support.…”

“…However, this patient had a megaloblastic marrow, so that it is possible that haemolysis of immature cells was causing a raised bilirubin and a low haptoglobin level without the peripheral haemoglobin destruction rate being greatly affected (Owen, Carew, Cowling, Hoban, and Smith, 1960b). Effect of Splenectomy.-In four cases serum haptoglobins were measured before and after splenectomy (Table VI).…”

“…In a previous paper (Owen, Carew, Cowling, Hoban, and Smith, 1960b), the view was put forward that a low serum haptoglobin level associated with increased haemolysis is most likely due to the formation of a haemoglobinhaptoglobin complex in the plasma and to its subsequent removal from the circulation. The finding (Table V) of a negative correlation between haemoglobin destruction and serum haptoglobin supports this view, as does the negative correlation between serum bilirubin and haptoglobin levels observed in this investigation and in a previous study (Owen et al, 1960b).…”

“…The purpose of this paper is to record serum haptoglobin levels in a number of different types of haemolytic disorders, to assess the relation of rate and site of haemolysis to the serum haptoglobin levels, and to examine the value of this estimation as an aid in the diagnosis of haemolytic states. Methods Serum haptoglobins were measured by a colorimetric procedure (Owen, Better, and Hoban, 1960a). The results have been expressed in terms of methaemoglobin-binding capacity (mg./100 ml.).…”

Haptoglobin and Increased Haemolysis

“…Ob servations were stopped on the 32nd day of treatment. These data are in accordance with the findings of Nyman [22] and Owen et al [26].…”