Serum heat shock protein and anti-heat shock protein antibody levels in aging

Rea, Irene Maeve; McNerlan, Susan E.; Pockley, A. Graham

doi:10.1016/s0531-5565(00)00215-1

Cited by 157 publications

(117 citation statements)

References 34 publications

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“…22,23 Recently, it was found that it is possible to lengthen the life span of an organism using hsps. [24][25][26] In ocular tissue, especially the retina, hsp70 is a major stress protein. Hsp70 in mice is composed of the end products of hsp70.1, 70.2, and 70.3 [18][19][20][21] and has retinal protective effects against various stresses.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect ofHeat Shock Proteins 70.1and70.3on Retinal Photic Injury after Systemic Hyperthermia

Kim

et al. 2005

Korean J Ophthalmol

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Purpose: This study aimed to determine the relationship between the heat shock protein 70 from hsps70.1 and 70.3 on retinal photic injury after systemic hyperthermia. Methods: Eight-week-old female C57BL/6 mice were kept at a constant temperature of 41~42℃ for 25~30 minutes. After dark-adaptation for 8 hours, intense light of 11000 lux was maintained for 6 hours. Histology and immunohistochemistry for the inducible heat shock protein 70 (hsp70), the constitutive heat shock protein 70 (hsc70), and western blot analysis, reverse transcriptase-polymerase chain reaction for hsp70.1 and hsp70.3 were performed just before photic injury and after 1, 4, 7, and 14 days. Results: Light-induced retinal degeneration was prevented by thermotolerance. After hyperthermia, hsp70 was densely expressed in the inner segment of the photoreceptor layer on the photic injury. Hsp70 expression increased for 4 days after photic injury and slowly decreased thereafter. mRNA from hsp70.3 was induced earlier than that of hsp70.1. Conclusions: Retinal photic injury was prevented by hyperthermia-induced hsp70. Hsp70 from hsp70.3 may be a rapid and short-lived responder, and that from hsp70.1 is a slower and more sustained responder. Hsp70 from hsp70.3 may be an initial retinal chaperone while hsp70 from hsp70.1 may be a sustained chaperone.

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Section: Discussionmentioning

confidence: 99%

Protective Effect ofHeat Shock Proteins 70.1and70.3on Retinal Photic Injury after Systemic Hyperthermia

Kim

et al. 2005

Korean J Ophthalmol

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“…For further details, please refer to recent reviews [7,39,50,52,54,58,63,71,72,74]. Molecular chaperones used to be considered intracellular, but in recent years chaperones (predominantly the 70-kDa heat shock protein -Hsp70) were also found extracellularly in human blood sera [64,66,88], and the presence of some other chaperones (cpn10 and cpn60) was also reported in pancreatic juice [83]. The presence of a key molecular chaperone (Hsp70) in human saliva was also demonstrated in our previous studies [26,27], indicating a possible effect of Hsp70 not only in the extracellular compartment and blood, but on mucosal surfaces as well.…”

Section: Introductionmentioning

confidence: 99%

Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms

Fábían

Fejérdy

Nguyen

et al. 2007

Arch. Immunol. Ther. Exp.

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Molecular chaperones were considered to be intracellular, but there is increasing evidence demonstrating their cytoprotective and immune modulator properties outside the cell. The major extracellular chaperone (Hsp70) was also found in saliva, indicating a possible effect of Hsp70 on mucosal surfaces. Here we summarize the immune-modulatory role of the 70-kDa stress protein family, with special attention on the potential impact of salivary Hsp70 on oral defense mechanisms. There are three major facets of Hsp70-induced immune activation: 1) the appearance of Hsp70 on the surface of certain tumor cells or virally infected cells, leading to their phagocytosis and subsequent lysis; 2) the role of extracellular uncomplexed Hsp70 as a danger signal, leading to the secretion of proinflammatory cytokines from antigen-presenting cells and T lymphocytes and of nitric oxide from macrophages as well as to complement activation; 3) receptor-mediated uptake of peptide-loaded Hsp70 to antigen-presenting cells and cross-presentation of the Hsp70-peptide complex as an antigen to cytotoxic T cells and natural killer lymphocytes. The immune-activating effect of salivary Hsp70 may also be highly important in oral defense, especially in areas where molecular and cellular participants of the immune response appear on the surface of the oral cavity (i.e. several lesions of the mucosa and the periodontal tissues).

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“…Rea et al (2001) reported that HSP60 can be detected in healthy subjects with age range of 20-96 years and a progressive decrease in HSP60 levels was detected with increasing age and they mentioned that this decrease with age did not appear to be related to anti-heat shock protein antibody status. At the same time, Macario et al (2010) stated that the levels and functional quality of intracellular HSPs, as a rule, decrease with age but their over expression mostly occurs as a response to various stressors ( as noise), resulting in their intracellular accumulation.…”

Section: Resultsmentioning

confidence: 99%

Association of Heat Shock Protein 60 With Noise-Induced Hearing Impairment and Electrocardiographic Abnormalities Among Workers Occupationally-Exposed to Noise

Gh¹,

Manawil²,

Diaa

2018

Egypt. J. Occup. Med.

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Introduction: Heat Shock Protein 60 (HSP 60) and other heat shock proteins play an important role in cellular survival under stressful conditions. HSP 60 participates in the course of many cardiovascular diseases. Exposure to severe noise can results in induction of heat shock proteins (HSPs). Aim of Work: to explore a possible association between HSP 60 and both noise-induced hearing loss (NIHL) and electrocardiographic (ECG) abnormalities among workers occupationally exposed to noise. Material and methods: A cross-sectional comparative study was conducted on 35 workers exposed to noise at work and 42 individuals as a control group. Pure-tone audiometry was carried out to all participants. ECG recordings and measurements of HSP 60 levels in serum were also performed to the exposed and the control using enzyme linked immunosorbent assay (ELISA) technique. Results: Statistically significant differences (P < 0.05) were found on comparing exposed workers and control group as regards HSP 60 levels, ECG abnormalities and NIHL in low and high frequencies. A comparison between HSP 60 levels with ECG abnormality among the exposed workers revealed a statistically non-significant difference (P < 0.05). Meanwhile, statistically highly significant differences were found on comparing HSP 60 levels in the normal hearing exposed workers with each of the NIHL subgroups as regards low frequency hearing loss (P < 0.01) and high frequency hearing loss (P < 0.001). Conclusion: The study revealed an association between serum HSP 60 levels and NIHL, but no association was found between serum HSP60 and ECG abnormalities among workers occupationally exposed to noise.

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Serum heat shock protein and anti-heat shock protein antibody levels in aging

Cited by 157 publications

References 34 publications

Protective Effect ofHeat Shock Proteins 70.1and70.3on Retinal Photic Injury after Systemic Hyperthermia

Protective Effect ofHeat Shock Proteins 70.1and70.3on Retinal Photic Injury after Systemic Hyperthermia

Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms

Association of Heat Shock Protein 60 With Noise-Induced Hearing Impairment and Electrocardiographic Abnormalities Among Workers Occupationally-Exposed to Noise

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