Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

Zhang, P; Du, Hongbo; Tong, Guangdong; Li, X K; Sun, Xuehua; L, X; Xing, Yufeng; Zhou, Zhenhua; Li, Q; Chen, B; Wang, H; Wang, L; Jin, Hua; Mao, Dewen; Wang, X B; Wu, Qikai; Li, F P; Hu, Xiaoyu; Lu, Bingjiu; Yang, Zhiyun; Zhang, M X; Shi, Weibin; He, Qing-Yu; Li, Y; Jiang, Kaiping; Xue, Jianya; Li, X D; Jiang, Junmin; Lu, Wei; Tian, G; Hu, Zhenbin; Guo, Jianhua; Li, C Z; Deng, Xin; Luo, Xinhua; Li, F Y; Zhang, X W; Zheng, Yi; Zhao, Guangjie; Wang, L C; Wu, Jianhua; Guo, Hui; Mi, Yuqiang; Gong, Zuojiong; Wang, C B; Jiang, Feng; Guo, Peng; Yang, Xianzhao; Shi, Weilin; Yang, Hongzhi; Zhou, Yi; Sun, Nan; Jiao, Yunzhe; Gao, Yueqiu; Zhou, Daoguo; Ye, Y A

doi:10.1111/jvh.12903

Cited by 13 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have investigated the correlation of serum HBsAg and HBV DNA with liver pathological grades and stages in patients with chronic HBV infection [31][32][33][34][35][36]. e results of this study were basically consistent with those studies.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies have shown that serum HBsAg of HBeAg-positive patients and serum HBV DNA of HBeAgnegative patients are valuable but not very satisfactory in predicting liver inflammation intensities and fibrosis levels [31][32][33][34][35][36]. Lately, preliminary studies have demonstrated that anti-HBc may be useful in predicting liver inflammation intensities and fibrosis levels [15][16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

Zhang

Shi

et al. 2019

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Background. Changes of hepatitis B core antigen antibody (anti-HBc) in liver pathological involvement in patients with chronic hepatitis B virus (HBV) infection have not been investigated in detail. This study aimed to explore evolving patterns of anti-HBc following liver pathological states and to investigate validities of anti-HBc for predicting liver pathological states. Methods. 254 HBeAg-positive and 237 HBeAg-negative patients with chronic HBV infection were enrolled. Liver pathological diagnoses referred to Scheuer standard, and anti-HBc was measured using chemiluminescence microparticle immunoassay. Results. Anti-HBc was significantly positively correlated with pathological grades and stages in both HBeAg-positive (rs = 0.312, P<0.0001, and rs = 0.268, P<0.0001) and HBeAg-negative (rs = 0.270, P<0.0001, and rs = 0.147, P=0.0237) patients. The medians of anti-HBc in pathological grades of G1, G2, and G3 and stages of S1, S2, S3, and S4 in HBeAg-positive patients were all significantly lower than those in HBeAg-negative patients (all P<0.005). The areas under receiver-operating characteristic curves (95% confidence interval) of anti-HBc for predicting pathological grades ≥G2 and ≥G3, and stages ≥S2 and =S4 in HBeAg-positive patients were 0.683 (0.622–0.740) and 0.662 (0.601–0.720), and 0.627 (0.564–0.687) and 0.683 (0.622–0.740), respectively, and in HBeAg-negative patients were 0.681 (0.618–0.740) and 0.702 (0.639–0.760), and 0.569 (0.503–0.633) and 0.630 (0.565–0.691), respectively. Conclusion. Following hepatic aggravation of necroinflammation and progression of fibrosis, anti-HBc increases gradually in HBeAg-positive patients and continues to increase gradually in HBeAg-negative patients, which is a useful but unsatisfactory marker for monitoring pathological states.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

Zhang

Shi

et al. 2019

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…HBsAg and HBeAg were roughly parallel to HBV DNA quantities in the absence of drug and virus mutations (12)(13)(14)(15). It was recognized that HBsAg can predict CHB progression and can be used to monitor antiviral efficacy in chronic HBV infected patients (16)(17)(18)(19). In our results, there were significant differences between the Minimal grade and Non-minimal grades (mild, moderate) group in age, ALT, AST, serum HBsAg, HBeAg, and HBV DNA quantitation by analysis of factors associated with liver inflammation.…”

Section: Discussionmentioning

confidence: 99%

AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection

et al. 2020

Hepat Mon

View full text Add to dashboard Cite

Objectives: The current study aimed to investigate the characteristics of HBV serum markers (HBsAg, HBeAg), biochemical indicators, HBV DNA, and the age to distinguish minimal from non-minimal liver histological inflammation group in HBeAg-positive chronic HBV-infected patients with ALT≤ 1ULN (40U/L). Methods: The HBeAg-positive patients with treatment-naïve hospitalized at Ditan hospital from January 2008 to January 2017 are investigated. Patients were separated into two groups of minimal and non-minimal (mild and moderate) histological inflammation group by liver biopsy specimens. Data were analyzed using the SPSS package. Results: There were both positive (age, ALT, and AST) and negative correlation factors (serum HBsAg, HBeAg, or HBV DNA quantitation) to the liver inflammation grades. Multivariate regression analysis indicated that HBeAg (P < 0.001, b = -0.554, Exp (B) = 0.575) and AST (P = 0.003, b = 0.074, Exp (B) = 1.077) were independent influential factors. The cutoff values of HBeAg and AST were separately 2.85 Log10S/CO (AUC0.724, Sensitivity64%, Specificity79%), 28U/L (AUC0.726, Sensitivity68%, Specificity 78%) to distinguish Minimal from Non-minimal liver histological inflammation in chronic HBV-infected patients with ALT ≤ 1 ULN (40U/L). Conclusions: In total, 31.34% (115/367) of patients with chronic HBV infection who had non-minimal (mild and moderate) liver histological inflammation reached the required inflammation levels for antiviral treatment in HBeAg-positive patients with persistently normal ALT. HBeAg (cutoff < 2.85 Log10S/CO) and AST (cutoff > 28 U/L) were the independent influential factors of predicting non-minimal liver inflammation with ALT ≤ 1 ULN (40U/L).

show abstract

“…Whether the HPCV could affect viral replication and the level of serum HBV DNA levels and HBsAg titers is not well clear. Therefore, it is necessary to Current studies indicated that the expression of HBV DNA and HBsAg is declined in CHB patients with hepatic fibrosis (8,9). However, the previous study showed that the decrease in HBV DNA level from liver fibrosis stage from 1 to 4 is not a true reflection of a decline of viral replication level in hepatic parenchyma cells.…”

Section: Statistical Analysis Of Serum Hbv Dna/hbsag Serum Hbv Dna/hbsag Apportioned By the Same Hpcv In Different Inflammation Gradesmentioning

confidence: 97%

“…The more accumulation of inflammation and fibrosis caused by a viral infection, the less hepatic parenchyma cell volume (HPCV) can be provided to HBV replication (4,5). In clinical practice, the replication of HBV is usually assessed by viral DNA load and HBV surface antigen (HBsAg) in serum (6,7), and the decline of these two clinical parameters was often observed in CHB patients with hepatic fibrosis in different degree (8,9). However, the dynamic changes of serum HBV DNA and HBsAg levels in different liver inflammation grades are not well clear.…”

Section: Introductionmentioning

confidence: 99%

A perspective of the relationship of serum HBV DNA and HBsAg apportioned by the same hepatic parenchyma cell volume with inflammation in the natural history of chronic hepatitis B

Tan¹,

Wu²,

Zhao³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: This study aimed to investigate the dynamic changes of serum HBV DNA and hepatitis B surface antigen (HBsAg) titers apportioned by the same hepatic parenchyma cell volume (HPCV) at different liver histological inflammation grades in the natural history of chronic hepatitis B (CHB). Methods:The serum HBV DNA and HBsAg titers were detected by real-time polymerase chain reaction and electrochemiluminescence, separately, in CHB patients without any treatment. The serum HBV DNA levels and HBsAg titers apportioned by the same HPCV were figured out based on sphere geometry theory.In addition, the differences of HBV DNA levels and HBsAg titers apportioned by the same HPCV in different liver inflammation grades were further assessed based on statistical analysis.Results: There was no difference of serum HBV DNA levels or HBsAg titers before apportioned by the same HPCV in liver inflammation grades 1-4, but significant differences were observed after apportion in CHB patients (HBV DNA: P=0.101; HBsAg: P=0.211 & HBV DNA apportioned by HPCV: P<0.001; HBsAg apportioned by HPCV: P<0.001). No correlation was observed between HBV DNA levels and liver inflammation grades (r=0.083, P=0.186), or between HBsAg titers and liver inflammation grades (r=0.083, P=0.078). A significant correlation was observed between HBV DNA levels apportioned by HPCV and liver inflammation grades (r=0.249, P<0.001), and obvious correlation of HBsAg titers apportioned by HPCV and liver inflammation grades was also found in CHB patients (r=0.554, P<0.001).Conclusions: These results suggest that the levels of serum HBV DNA and HBsAg apportioned by the same HPCV are correlated with the severity of liver histological inflammation grade in the natural history of CHB.

show abstract

Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

Cited by 13 publications

References 35 publications

Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection

A perspective of the relationship of serum HBV DNA and HBsAg apportioned by the same hepatic parenchyma cell volume with inflammation in the natural history of chronic hepatitis B

Contact Info

Product

Resources

About