Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women

Young, Melissa; Glahn, Raymond P.; Ariza‐Nieto, Magnolia; Inglis, Jeremy; Olbina, Gordana; Westerman, Mark; O’Brien, Kimberly

doi:10.3945/ajcn.2008.26589

Cited by 101 publications

(105 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In healthy human volunteers hepcidin in urine and serum increased upon oral iron dosing, although nonresponders were reported (29,59,112,(145)(146)(147). Some studies report a weak, but significant, negative correlation between serum hepcidin concentrations and iron absorption (112,146,147 ).…”

Section: Effect Of Iron Administration On Hepcidin Concentrationsmentioning

confidence: 99%

Hepcidin in Human Iron Disorders: Diagnostic Implications

et al. 2011

View full text Add to dashboard Cite

BACKGROUND:The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.CONTENT: We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice.

show abstract

Section: Effect Of Iron Administration On Hepcidin Concentrationsmentioning

confidence: 99%

Hepcidin in Human Iron Disorders: Diagnostic Implications

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Iron deficiency and erythropoiesis are each associated with suppressed hepatic hepcidin release, 6,33 facilitating increased intestinal iron absorption 17 and release from macrophage stores 3 through intact membrane ferroportin on the basolateral aspect of enterocytes 34,35 and macrophages. 35 Thus, reduced hepcidin is an essential part of the physiological response to an iron deficit.…”

Section: S-r Pasricha Et Almentioning

confidence: 99%

“…Since ferritin (an index of iron stores), sTfR (an index of erythropoietic marrow iron depletion) and hepcidin (a signal that increased iron is needed) each reflect different aspects of iron metabolism, combined evaluation of these indices may provide complementary clinical information. A low hepcidin concentration may predict efficient intestinal absorption of supplemental iron, 17 potentially identifying patients who would benefit most from oral iron therapy.…”

Section: S-r Pasricha Et Almentioning

confidence: 99%

Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors

Pasricha¹,

McQuilten²,

Westerman³

et al. 2011

Haematologica

View full text Add to dashboard Cite

BackgroundCurrently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties of hepcidin as a diagnostic test of iron deficiency. Design and MethodsSera from female, non-anemic, whole blood donors were analyzed for hepcidin (enzymelinked immunosorbent assay), ferritin, soluble transferrin receptor and C-reactive protein. Iron deficiency was defined as (i) serum ferritin less than 15 ng/mL or (ii) soluble transferrin receptor /log(ferritin) index greater than 3.2 if the C-reactive protein concentration was less than 10 mg/L, or greater than 2.2 if the C-reactive protein concentration was greater than 10 mg/L). Receiver operating characteristic curves were plotted to determine the overall utility and identify optimal cut-points of hepcidin as a test of iron deficiency. ResultsIn 261 blood donors the prevalence of iron deficiency defined by ferritin concentration was 59/261 [22.6% (17.5, 27.7)], whereas defined by soluble transferrin receptor/log(ferritin) index it was 53/261 [20. 4% (15.4, 25.2)]. The 95% reference range of hepcidin concentration in the iron-replete population was 8.2-199.7 ng/mL. The area under the receiver operating characteristic curve for hepcidin compared with ferritin concentration less than 15 ng/mL was 0.87 (0.82, 0.92), while that compared with the soluble transferrin receptor /log(ferritin) index was 0.89 (95% CI 0.84, 0.93). For a diagnosis of iron deficiency defined by the soluble transferrin receptor/log(ferritin) index, hepcidin less than 8 ng/mL had a sensitivity of 41.5% and a specificity of 97.6%, while hepcidin less than 18 ng/mL had a sensitivity of 79.2% and a specificity of 85.6%. ConclusionsSerum hepcidin concentration may be a useful indicator of deficient iron stores. Further studies are required to evaluate the role of hepcidin in the diagnosis of iron deficiency in other groups of patients.

show abstract

“…Natural iron isotope variations in the blood may serve to identify differences in intestinal iron absorption between individuals and genotypes [15]. Moreover, 57 Fe and 58 Fe have already been used as tracers in nutritional studies on humans due to their low natural abundance [16,17,18].…”

Section: Introductionmentioning

confidence: 99%