Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

Radzicka, Sandra; Ziółkowska, Katarzyna; Zaborowski, Mikołaj; Brązert, Jacek; Pietryga, Marek

doi:10.5603/gp.2019.0066

Cited by 25 publications

(24 citation statements)

References 26 publications

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“…In healthy pregnant women, serum Hcy levels decrease during pregnancy due to the physiological decline of albumin and folic acid supplementation. However, Radzickad et al [17] showed that there was no statistically significant difference in serum Hcy levels between the GDM group and the control group at different stages of pregnancy, which was consistent with our study. Therefore, the relationship between serum Hcy level and GDM remains to be further studied.…”

Section: Discussionsupporting

confidence: 93%

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Liu

Huang

Tang

et al. 2021

Gynecol Obstet Invest

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Background: Inflammatory response state is related to the pathogenesis of gestational diabetes mellitus (GDM). Objective: To investigate the changes of serum sex hormone-binding globulin (SHBG), homocysteine (Hcy), and hypersensitive CRP (hs-CRP) levels during pregnancy and their relationship with GDM. Methods: The nested case-control study method was used. Sixty nonobese single pregnant women diagnosed with GDM were divided into the GDM group (GDM, n = 60), together with another 60 pregnant women with normal glucose tolerance who were matched in the same period and divided into the control group (control, n = 60). The serum Hcy, hs-CRP, and SHBG levels were measured. Results: The serum levels of Hcy and hs-CRP were significantly higher in the GDM group compared with the control group, and serum levels of SHBG was significantly lower in the GDM group compared with the control group at different stages of pregnancy. The serum levels of Hcy and hs-CRP in pregnant women increased with the increase of gestational age, and serum levels of SHBG decreased with the increase of gestational age. Increased Hcy and hs-CRP levels in the second trimester and decreased SHBG levels in the first trimester were related to GDM. The odds ratio (OR) and 95% confidence interval (CI) were as follows: OR: 4.5, 95% CI: 1.5–13.0; OR: 4.2, 95% CI: 1.5–10.1; and OR: 0.4, 95% CI: 0.3–0.7, respectively. Conclusion: Increased Hcy and hs-CRP in the second trimester and decreased SHBG in the first trimester were independent predictors of GDM, which provides a new idea for early prevention and treatment of GDM.

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Section: Discussionsupporting

confidence: 93%

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Liu

Huang

Tang

et al. 2021

Gynecol Obstet Invest

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“…Table 4. Plasma concentrations of metabolites 5 h after the intravenous glucose administration and 3 h after the meal Item Even though Lind et al (2019) did not find any additional positive effects of combining folate supplement with vitamin B 12 on insulin sensitivity, there is growing evidence that serum vitamin B 12 concentration is inversely associated with glucose metabolism dysfunction in humans at different lifetime stages and conditions (Jayashri et al, 2018;Radzicka et al, 2019). Vitamin B 12 is also involved as a coenzyme for methylmalonyl-CoA mutase in the transformation of propionate, some AA, and odd-chained FA for their entry into the Krebs cycle to provide energy via gluconeogenesis (Combs and McClung, 2017).…”

Section: Discussionmentioning

confidence: 99%

Response to a glucose tolerance test in early-lactation Holstein cows receiving a supplementation of biotin, folic acid, and vitamin B12

Duplessis

Girard

2021

Journal of Dairy Science

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The aim of the study was to evaluate glucose and insulin metabolism of cows receiving a supplementation of biotin (B 8), folic acid (B 9), and vitamin B 12 (B 12) during the transition period. According to a 2 × 2 factorial arrangement, 32 cows were randomly assigned to 9 incomplete blocks according to their previous 305-d milk yield. Within each block, cows were randomly assigned to 1 of the following levels of biotin from −27 to 28 d relative to the parturition: (1) no biotin supplement (B 8 −) or (2) 20 mg/d of dietary biotin (B 8 +). Within each level of biotin, the cows received either (1) 2-mL weekly intramuscular injections of saline 0.9% NaCl (B 9 B 12 −) or (2) 2.6 g/d of dietary folic acid and 2-mL weekly intramuscular injections of 10 mg of vitamin B 12 (B 9 B 12 +). An intravenous glucose tolerance test was performed at 25 d in milk. Baseline plasma glucagon, glucose, and nonesterified fatty acid concentrations did not differ among treatments. For B 9 B 12 + cows, baseline plasma insulin concentration and maximal glucose concentration after glucose administration were greater when also combined with biotin compared with no biotin combination, whereas there was no effect in B 9 B 12 − cows. There was no treatment effect on time to reach half-maximal glucose and insulin concentrations, glucose positive incremental area under the curve, and glucose and insulin clearance rates. Regarding insulin results, maximal plasma concentration and positive incremental area under the curve were respectively 51 and 74% greater for cows receiving the B 8 supplement than for cows who did not. Moreover, plasma nonesterified fatty acid concentration nadir tended to be reached later for B 8 cows. Insulin peak was reached earlier for cows in the group B 9 B 12 + than cows in B 9 B 12 −, regardless of B 8 supplementation. Under the current conditions , our results suggested that cows receiving a B 8 supplement had a reduced insulin sensitivity in early lactation. Insulin response was faster for B 9 B 12 + cows, but this was not translated into further improvements following the glucose administration challenge.

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“…Compared to normal pregnancies, the serum Hct levels between 24 and 28 gestational weeks were elevated in GDM patients [ 50 ]. However, a study based in Poland tested serum Hct expressions among 60 GDM patients and 19 normal pregnant females [ 57 ]. The study did not find any difference in the Hct levels between the two groups [ 57 ].…”

Section: Hct and Gdmmentioning

confidence: 99%

“…However, a study based in Poland tested serum Hct expressions among 60 GDM patients and 19 normal pregnant females [ 57 ]. The study did not find any difference in the Hct levels between the two groups [ 57 ]. Hct was unassociated with fasting blood glucose and glycosylated hemoglobin [ 57 ].…”

Section: Hct and Gdmmentioning

confidence: 99%

A Novel Review of Homocysteine and Pregnancy Complications

Dai

Fei

et al. 2021

BioMed Research International

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Homocysteine (Hct) is a substance produced in the metabolism of methionine. It is an essential type of amino acid gained from the daily diet. Methylenetetrahydrofolate reductase (MTHFR) gene mutation is related to elevated total homocysteine (tHct) expressions, in particular, among women with low folate intake. Hyperhomocysteinemia (HHct) is caused by numerous factors, such as genetic defects, lack of folic acid, vitamin B6 and B12 deficiency, hypothyroidism, drugs, aging, and renal dysfunction. Increased Hct in peripheral blood may lead to vascular illnesses, coronary artery dysfunction, atherosclerotic changes, and embolic diseases. Compared to nonpregnant women, the Hct level is lower in normal pregnancies. Recent studies have reported that HHct was associated with numerous pregnancy complications, including recurrent pregnancy loss (RPL), preeclampsia (PE), preterm delivery, placental abruption, fetal growth restriction (FGR), and gestational diabetes mellitus (GDM). Besides, it was discovered that neonatal birth weight and maternal Hct levels were negatively correlated. However, a number of these findings lack consistency. In this review, we summarized the metabolic process of Hct in the human body, the levels of Hct in different stages of normal pregnancy reported in previous studies, and the relationship between Hct and pregnancy complications. The work done is helpful for obstetricians to improve the likelihood of a positive outcome during pregnancy complications. Reducing the Hct level with a high dosage of folic acid supplements during the next pregnancy could be helpful for females who have suffered pregnancy complications due to HHct.

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Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

Cited by 25 publications

References 26 publications

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Response to a glucose tolerance test in early-lactation Holstein cows receiving a supplementation of biotin, folic acid, and vitamin B12

A Novel Review of Homocysteine and Pregnancy Complications

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