Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study

Abstract

Introduction:The present study aimed to analyse if there is a correlation between carotid intima medial thickening (CIMT) and Hcy in stroke patients.Methodology:We studied 100 consecutive cases of acute anterior circulation strokes at St. John's Medical College, Bangalore, India. Fasting serum samples for homocysteine were sent within 24 hours of admission and all patients underwent a carotid Doppler scan and carotid intima-medial thickness (CIMT) was estimated on both sides.Results:There was significant correlation between serum homocysteine levels and carotid intima-medial thickness (r = 0.409, p = 0.000). Also after controlling for other possible risk factors it was found that elevations in serum homocysteine levels would cause a variation of 60% in the carotid intima-medial thickening.Conclusion:Serum Hcy levels correlate well with CIMT and hence may predict atherothrombotic events.

Prevalence of hyperhomocysteinemia during routine physical examination in Guangxi Province, China and related risk factors

“…Spontaneous oxidation can also lead to the development of thiol lactone compounds and transretinoic acid, both of which result in platelet aggregation, promote the formation of blood clots, and accelerate atherosclerosis. The simultaneous presence of high serum Hcy and blood lipid concentrations causes atherosclerosis and thrombosis, both of which are independent risk factors for cardiovascular disease …”

“…The prevalence of HHcy has gradually increased with continuous improvements in people's living standards and changes in lifestyles and eating habits. In 1969, McCully proposed that Hcy was likely to be related to atherosclerosis; later, study reported that Hcy was not only a risk factor for cardio‐cerebrovascular diseases but can also be used to predict diabetes, dementia, pregnancy syndrome, and other diseases . To date, studies on Hcy have mainly focused on the correlation of the Hcy concentration with disease; few epidemiological investigations of Hcy have been performed.…”

Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol

“…SHENG-CHAO MA 1* , HUI-PING ZHANG 2* , YUN JIAO 3 , YAN-HUA WANG 1 , HUI ZHANG 1 , XIAO-LING YANG 1 , AN-NING YANG 1 and YI-DENG JIANG 1 and migration (12). PTEN overexpression in VSMCs using adenovirus transfection results in inhibition of cell proliferation and migration induced by angiotensin II (13).…”

“…Epidemiologic and case control studies have consistently indicated that moderate and mild elevation of plasma homocysteine (Hcy), an intermediate metabolite of methionine, is an independent risk factor in the development of atherosclerosis (AS) (1). Previous studies have intensively focused on the involvement of Hcy in the dysfunction and injury of vascular cells, including vascular smooth muscle cells (VSMCs) (2,3).…”

Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy

“…Previous studies have demonstrated that elevated levels of homocysteine (Hcy) have been implicated as an independent risk factor for atherosclerosis (AS) (1)(2)(3). Studies have focused on the involvement of Hcy on the dysfunction and injury of vascular cells, such as vascular smooth muscle cells (VSMCs) (4,5).…”