Serum homocysteine concentration as a marker for advanced diabetic nephropathy in a cohort of elderly patients

Zheng, Xulei; Liu, Qiaorui; Liu, Zhiwen

doi:10.1186/s12902-023-01342-1

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Nos últimos anos, muitos agentes hipoglicemiantes com efeito protetor de órgão tornaram-se disponíveis. Todavia, a avaliação do risco de cada indivíduo continua a ser fundamental para o tratamento adequado da doença renal diabética (TOYAMA et al, 2023;ZHENG;LIU;LIU, 2023;HILL et al, 2023).…”

Section: Introductionunclassified

“…Os fatores de risco associados à nefropatia diabética (ND) incluem dislipidemia, hipertensão, tabagismo, bem como o grau de controle glicêmico. Fatores de risco não modificáveis incluem idade, etnia, perfis genéticos, com hipertensão e hiperglicemia sendo particularmente importantes (ZHENG;LIU;LIU, 2023;HILL et al, 2023).…”

Section: Introductionunclassified

“…A ND é caracterizada por um aumento acentuado na excreção de albumina na urina, lesões glomerulares diabéticas e uma taxa de filtração glomerular estimada reduzida (eGFR) em pacientes com diabetes. No entanto, na população idosa, um declínio da eGFR é um processo fisiológico normal devido ao aumento da glomeruloesclerose e diminuição do número de néfrons funcionais (HILL et al, 2023;ZHENG;LIU;LIU, 2023).…”

Section: Introductionunclassified

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Fatores de risco das nefropatias diabéticas na população geriátrica

Vasconcelos,

Guerra,

Guimarães

et al. 2024

Cuad. Ed. Desar.

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A incidência de diabetes mellitus (DM) é de cerca de 8,8% para indivíduos com idade entre 20 e 79 anos e afetou cerca de 440 milhões de pessoas globalmente em 2015, com os números projetados para aumentar para > 550 milhões até 2035. Aproximadamente 30 a 40% dos indivíduos com diabetes desenvolvem doença renal. Assim, objetiva-se elucidar quais são os principais fatores de risco das nefropatias diabéticas na população geriátrica de acordo com a licenciatura. Realizou-se uma revisão sistemática da literatura. Inicialmente foram encontrados 925 estudos, que após aplicação dos critérios de exclusão e inclusão, resultaram no total de 9 estudos incluídos na presente revisão. A senescência é um fator de risco para o desenvolvimento de ND em pacientes diabéticos. O rim é um órgão imprescindível para o ser humano, portanto, deve ter acompanhamento e cuidado pelos profissionais da saúde, em especial, escolher e solicitar exames menos invasivos para a população geriátrica, a fim de diminuir os riscos e exposição de tais indivíduos a complicações.

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Section: Introductionunclassified

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Fatores de risco das nefropatias diabéticas na população geriátrica

Vasconcelos,

Guerra,

Guimarães

et al. 2024

Cuad. Ed. Desar.

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“…Hcy can be utilized in two ways-remethylation (RM) or trans-sulfonation (TS)-followed by regeneration into methionine or conversion into cysteine, respectively [18][19][20]. In recent studies, data from experimental and clinical studies have been presented, indicating the association of homocysteine (Hcy) [21][22][23][24][25][26], as well as its precursors SAM and SAH [27][28][29][30][31], with the development of acute and chronic renal failure. At the same time, the mechanisms of methionine cycle disruption in CKD are not fully understood and may be associated with a decrease in the elimination of these metabolites, as well as the violation of their renal and systemic metabolism [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease

Kruglova,

Ivanov,

Fedoseev

et al. 2023

JCM

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We examined standard clinical and laboratory biochemical parameters, as well as the levels of aminothiols in the blood and urine (homocysteine (Hcy), cysteine (Cys), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)) via capillary electrophoresis in patients with CKD at stages II–V. Patient outcomes were assessed after five years. To complete forecasting, correlation and ROC analysis were performed. It was found that the levels of Cys and Hcy in blood plasma were earlier markers of CKD starting from stage II, while the levels of SAM and SAM/SAH in urine made it possible to differentiate between CKD at stages II and III. Blood plasma Hcy and urinary SAM and SAM/SAH correlated with mortality, but plasma Hcy concentrations were more significant. Thus, plasma Hcy, urine SAM, and SAM/SAH can be considered to be potential diagnostic and prognostic markers in patients with CKD.

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Hyperhomocysteinemia and Disease—Is 10 μmol/L a Suitable New Threshold Limit?

Marroncini,

Martinelli,

Menchetti

et al. 2024

IJMS

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Hyperhomocysteinemia (HHcy) is a medical condition characterized by an abnormally high level of homocysteine (Hcy) in the blood. Homocysteine is a toxic sulfur-containing amino acid that is produced during the metabolism of methionine. Under normal circumstances, Hcy is recycled back to methionine via the remethylation pathway, through the action of various enzymes and vitamins, particularly folic acid (vitamin B9) and B12 used when intracellular methionine levels are low, thus restoring the necessary levels to correctly maintain active protein synthesis. A second pathway, used in cases of intracellular methionine excess, (the trans-sulfuration pathway) is the one that recycles Hcy into cysteine (a precursor of glutathione), first passing through cystathionine (via the enzyme cystathionine beta-synthase), a reaction that requires vitamin B6 in its active form. HHcy has been identified as a risk factor for a variety of disorders, including cardiovascular diseases, multiple sclerosis, diabetes, Alzheimer’s and Parkinson’s diseases, osteoporosis and cancer. However, it remains unclear whether the slightly elevated concentration of Hcy (Hcy 7–10 μmol/L) is a causative factor or simply a marker of these pathologies. In human plasma, the concentration of Hcy ([Hcy]) is classified as mild (15 to 30 μmol/L), moderate (30 to 100 μmol/L), and severe (greater than 100 μmol/L). Interestingly, many laboratories continue to consider 25 μmol/L as normal. This review seeks to examine the controversial literature regarding the normal range of HHcy and emphasizes that even a [Hcy] level of 10 μmol/L may contribute to the development of several diseases, aiming to discuss whether it would be appropriate to lower the threshold of HHcy normal values.

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Serum homocysteine concentration as a marker for advanced diabetic nephropathy in a cohort of elderly patients

Cited by 3 publications

References 24 publications

Fatores de risco das nefropatias diabéticas na população geriátrica

Fatores de risco das nefropatias diabéticas na população geriátrica

The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease

Hyperhomocysteinemia and Disease—Is 10 μmol/L a Suitable New Threshold Limit?

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