Serum homocysteine level in pediatric patients with COVID‐19 and its correlation with the disease severity

Fouda, Eman; Wahba, Nancy Samir; Elsharawy, Asmaa Ismail Mohamed; Ishak, Sally Raafat

doi:10.1002/ppul.25920

Cited by 10 publications

(3 citation statements)

References 39 publications

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“…Liver tests indicative of liver injury, particularly ALT, ferritin, CRP levels, and D-dimer, have been shown to be associated with a poor prognosis and [23]. In the study by Fouda et al of 40 pediatric patients with COVID-19, the Hcy levels were higher in patients than in controls and were associated with disease severity and need for intensive care [24]. Tere are few studies investigating the association between high Hcy levels and disease severity in COVID-19 [25].…”

Section: Discussionmentioning

confidence: 98%

Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia

Sarı

Keskin

Keski̇n

et al. 2023

International Journal of Clinical Practice

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Background/Aim. Coronavirus disease 2019 (COVID-19) is a life-threatening disease characterized by a prothrombotic state. Because homocysteine (Hcy) is a potential biomarker in thrombotic disease, this article aims to highlight the role of Hcy in the prognosis of COVID-19 pneumonia. Methods. This prospective study was conducted between April 2021 and December 2021 at the University of Health Sciences, Antalya Training and Research Hospital. 162 patients admitted to the emergency department for COVID-19 pneumonia and scheduled for hospitalization in the intensive care unit (ICU) or COVID-19 ward of the chest disease department were included in the study. Hcy levels and other necessary laboratory parameters were analyzed. Results. 134 patients were admitted to the COVID-19 ward and 28 to the ICU. Hcy levels were significantly higher in ICU patients than in ward patients ( p : 0.001 ). Of the 134 patients, 55 later required ICU treatment for various reasons and were transferred to the ICU. Hcy ( p : 0.010 ), ferritin ( p : 0.041 ), and LDH ( p : 0.010 ) were significantly higher in patients who were transferred to the ICU than in patients who remained in the ward. The Hcy level was associated with a poor prognosis. It was found that each unit increase in the Hcy level approximately doubled the risk of death in patients with COVID-19 (odds ratio: 1.753). Discussion. There are few studies examining the association between high Hcy levels and disease severity in COVID-19. Our study supports previous studies and shows the association between the need for intensive care and high Hcy levels. Conclusion. A high Hcy value is a helpful marker in determining the need for critical care on admission to the emergency department and a marker of poor prognosis in COVID-19 pneumonia.

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Section: Discussionmentioning

confidence: 98%

Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia

Sarı

Keskin

Keski̇n

et al. 2023

International Journal of Clinical Practice

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“…A meta-analysis of HIV-infected subjects under antiretroviral therapy revealed that mean homocysteine levels were elevated compared to non-treated HIV subjects (49), suggesting that the maintenance of homocysteine levels is important for sustaining cellular health. Homocysteine has also been implicated as a potential biomarker of COVID-19 infection as levels were increased in COVID-19 patients (50,51) and remained elevated for three months in subjects diagnosed with COVID-19-associated pneumonia (50). While our results substantiate the idea that viral infections perturb homocysteine metabolism, resulting in profound changes in levels, they advance our knowledge by indicating that the initial insult may suppress cysteine metabolism.…”

Section: Discussionmentioning

confidence: 99%

HAdV-5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts

Sanchez,

Ortiz,

Grasis

2024

Preprint

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Viral infections can cause cellular dysregulation of metabolic reactions. Viruses alter host metabolism to meet their replication needs. The impact of viruses on specific metabolic pathways is not well understood, even for a well-studied virus-like human adenovirus. Adenoviral infection is known to affect cellular glycolysis and respiration, however, global effects on cellular metabolic pathways in response to adenoviral infection are lacking, particularly in normally quiescent structural cells, such as fibroblasts. Further, few studies have employed an untargeted approach with an emphasis on viral dosage and duration of infection. To address this, we employed untargeted metabolomics to quantify the dynamic metabolic shifts in fibroblasts infected with human adenovirus serotype 5 (HAdV-5) at three dosages (0.5, 1.0, and 2.0 multiplicity of infection [MOI]) and across four time points (6, 12, 24, and 36 h post-infection [HPI]). The greatest differences in individual metabolites were observed at 6– and 12-hours post-infection. In addition to its effects on glycolysis and respiration, adenoviral infection downregulated cysteine and unsaturated fatty acid metabolism, while upregulated purine metabolism. These results reveal the specific metabolic pathways that are perturbed by adenoviral infection and the associated dynamic shifts in metabolism, suggesting that viral infections alter energetics via profound changes in protein, lipid, and nucleic acid metabolism. The results revealed previously unconsidered metabolic pathways disrupted by HAdV-5 that can alter cells, even in non-excitable structural cells, such as fibroblasts.ImportanceHuman adenoviruses overtake the DNA replication machinery of the infected host, rewiring mitotic events and leading to effects on cellular respiration and glycolysis. Fibroblast lineages are normally quiescent cells that display a repertoire of responses to certain agonists. While metabolism often begins with glucose breakdown in the form of aerobic glycolysis, additional pathways are important for the overall functioning of the cell. Data on shifts in the metabolism of fibroblast cells in response to human adenoviral infection are lacking. We used an untargeted metabolomic approach to better understand the dynamic metabolic changes in human kidney cells in response to three viral dosages across four time points post infection. Profound shifts were observed for the cysteine, purine, and unsaturated fatty acid metabolites. This analysis provides a global perspective and highlights previously underappreciated aspects of how human adenoviruses alter host metabolism.

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“…Due to the coexistence of those medical conditions and hyperhomocysteinemia, particularly in older people, Hcy has been named by the medical profession as the cholesterol of the 21st century [ 33 ]. Recently, homocysteine has been investigated during COVID-19, chronic kidney disease, oncogenesis and infertility, emphasizing an interest in this biomarker within the medical and scientific community [ 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses

Gołyński

Metyk

Ciszewska

et al. 2023

Animals

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Homocysteine is an endogenous, non-protein sulfuric amino acid, an intermediate metabolite formed by the methionine transmethylation reaction. Its elevated serum concentration in humans, hyperhomocysteinemia, is a sensitive indicator and a risk factor for coagulation disorders, cardiovascular diseases and dementia. However, the role of homocysteine in veterinary species has not been unequivocally established. Although some research has been conducted in dogs, cats, cattle and pigs, relatively few studies on homocysteine have been conducted in horses. So far, it has been established in this species that homocysteine has an atherogenic effect, plays a role in early embryo mortality and is responsible for the induction of oxidative stress. These preliminary findings support establishing a reference range in a normal population of horses, including horses in training and merit further investigations into the role of this amino acid in health and disease in this species.

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Serum homocysteine level in pediatric patients with COVID‐19 and its correlation with the disease severity

Cited by 10 publications

References 39 publications

Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia

Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia

HAdV-5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts

Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses

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