Serum Hyaluronic Acid and Procollagen III Amino Terminal Propeptide in Chronic Renal Failure

Honkanen, Eero; Fröseth, B; Grönhagen‐Riska, Carola

doi:10.1159/000168304

Cited by 26 publications

(18 citation statements)

References 13 publications

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“…The data in the present study confirm that patients with various chronic renal disease have increased PI 11N P [14,15]. When comparing serum PIIINP in the kidney-transplanted patients to the levels in patients with chronic renal disease it should be considered that all of the renal graft recipients except one received prednisolone, which in similar doses has been shown to reduce serum levels of PIIINP and PICP significantly [24].…”

Section: Discussionsupporting

confidence: 79%

“…From previous studies it is known that serum PIIINP may be increased in various renal diseases most likely as a result of increased renal fibrosis [14,15], The patients enrolled in the present study did not suffer from other conditions known to be related to increased fibrogenesis, such as arthritis or fibrosis of the liver. Some of the patients had native kidneys(s) in situ, which might be considered to contribute to the in creased serum PIIINP.…”

Section: Discussionmentioning

confidence: 91%

“…Both type I and type 111 collagens are synthesized in a precursor form, procollagen, which is characterized by the presence of extension propeptides at the amino-and carboxy-terminal ends [10], During synthesis, the propep tides are released to the circulation, although type III pro collagen may be incorporated to some extent into the con nective tissue retaining its amino-terminal propeptide. In creased serum levels of PIIINP have been reported in a number of conditions characterized by increased tissue fibrosis, such as liver fibrosis [11,12], systemic scleroderma [13] and in various chronic renal diseases [14,15]. At present, there is no information concerning PIIINP and PICP se rum values in renal transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

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Serum Propeptides of Type I and III Procollagens in Renal Transplant Recipients

Heickendorff

Frost

Madsen

et al. 1994

Nephron

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Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type III and type I collagens, we analyzed serum levels of the amino-terminal propeptide of type III procollagen (PIIINP) and the carboxy-terminal propeptide of type I procollagen (PICP) in 11 renal transplant recipients receiving cyclosporine (group CY) and a comparable group of 16 renal transplant recipients treated with azathioprine (group AZ). In addition, 27 healthy subjects and 15 patients with chronic renal disease and reduced renal function (group CRD) were examined. The cyclosporine-treated patients had serum PIIINP and PICP similar to the azathioprine-treated patients. Both groups of renal transplant recipients had significantly increased serum PIIINP compared to healthy controls (2p < 0.01) and serum PIIINP levels similar to group CRD in which serum PIIINP was also elevated compared to healthy controls (2p < 0.01). Mean serum PIIINP levels were: group CY 0.81 U/l (n = 11); group AZ 0.98 U/l (n = 16); controls 0.62 U/l (n = 27); and group CRD 1.06 U/l (n = 15). The renal graft recipients – both cyclosporine- and azathioprine-treated patients – had significantly increased PICP serum levels compared to healthy controls, but the patients with chronic renal disease had serum PICP levels which did not differ from that of healthy controls. Mean serum PICP levels were: group CY 174 μg/l; group AZ 151 μg/l; controls 106 μg/l; and group CRD 119 μg/l. A significant positive correlation was seen between serum creatinine and serum PIIINP in the renal graft recipients (r = 0.51, p < 0.01), but not in the patients with chronic renal disease (r =-0.009, p = 0.49). The data point to an increased synthesis of type I and III collagens in renal transplant recipients. The graft is most likely the source of the increased serum PIIINP and PICP levels. It is suggested that the increased serum levels of propeptides derived from collagen metabolism may reflect continuous immunological destruction of renal tissue causing inflammation and fibrosis.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Propeptides of Type I and III Procollagens in Renal Transplant Recipients

Heickendorff

Frost

Madsen

et al. 1994

Nephron

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“…Alternatively, these hyaluronidases could play a role in the metabolism of circulating HA. That the kidney could play a major role in the disposal of HA is supported by the observation that patients with renal failure display elevated levels of HA [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Expression Profile of Hyaluronidase mRNA Transcripts in the Kidney and in Renal Cells

Sun

Feusi

Sibalic

et al. 1998

Kidney Blood Press Res

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The accumulation of hyaluronan (HA) in the renal cortex is a characteristic feature of inflammatory renal diseases. Fragments of HA derived from high molecular weight precursors are known to display inflammatory effects in vitro and could, therefore, participate in immune renal injury. To understand the mechanisms of HA fragmentation in vivo we examined the expression of recently characterized mammalian hyaluronidases in normal and autoimmune kidneys and in cell lines. We found that transcripts for the lysosomal–type hyaluronidases Hyal1 and Hyal2 were constitutively expressed in normal and autoimmune kidneys as well as in tubular epithelial cells and in a macrophage cell line. The expression of hyaluronidase genes in the cell lines did not increase in response to treatment with tumor necrosis factor alpha or gamma interferon. Interestingly, transcripts for the testicular–type hyaluronidase PH–20 (Spam1, Hyal3) were also detected in normal and autoimmune kidneys as well as in tubular cells and macrophages. Transcript levels were higher in kidneys from male mice as compared with age–matched females. Again, transcript levels did not change in vitro in response to cytokines. We conclude that mRNA for three different hyaluronidases is found in murine kidneys. The functional role played by these hyaluronidases in the degradation and metabolism of HA remains to be investigated further.

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“…0.001). Honkanen et al [7] reported that the serum hyaluronic acid concentrations were increased in patients on hemodialysis, but that there were no differences in serum KL-6 levels between hemodialysis patients without lung disease and healthy controls. The serum KL-6 concentrations in our patients following hemodialysis showed no change in comparison with the concentrations before hemodialysis.…”

mentioning

confidence: 99%