Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

Anagnostopoulou, Eleni; Papanastasopoulou, Chrysanthi; Papastamataki, Maria; Kotsiou, Antonia; Topouzoglou, Zoi; Anagnostopoulos, Nikolaos; Sitaras, Nikolaos M.

doi:10.1159/000477574

Cited by 9 publications

(11 citation statements)

References 39 publications

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“…Serum (n = 51) Prognosis for acute myeloid leukemia [134] Urine (n = 513) Diagnosis for bladder cancer [135] Serum (n = 63) Diagnosis for upper gastrointestinal cancers [136] Cytosol (n = 120) Prognosis for colorectal cancer [137] Tissues (n = 46)/Sputum (n = 25) Diagnosis and prognosis for lung cancer [138] Serum/pleural (n = 96) Diagnosis and prognosis for malignant mesothelioma [139] Serum (n = 506) Prognosis for liver cancer in hepatic resection [140] Tissues (n = 45) Prognosis for nerve sheath tumor [141] Enzymes HPSE Tissues (n = 182) Prognosis for glioma [142] Serum (n = 156) Diagnosis for breast cancer [143] Serum (n = 177) Diagnosis for ovarian cancer [144] Tissues (n = 81) Prognosis for oral mucosal melanoma [145] HYAL-1 Tissues (n = 407/178) Prognosis for bladder cancer [146,147] Tissues (n = 70) Prognosis for prostate cancer [148] Urine (n = 513) Diagnosis for bladder cancer [149] Tissues (n = 34) Prognosis for colorectal cancer [150] HAS1 Tissues (n = 278) Prognosis for breast cancer [151] Tissues (n = 31) Prognosis for colon cancer [152] Tissues (n = 287) Prognosis for prostate cancer [153] HAS2 Tissues (n = 407) Prognosis for bladder cancer [146] HAS3 Tissues (n = 407) Prognosis for bladder cancer [146] Tissues (n = 278) Prognosis for breast cancer [151] MMP2 Tissues (n = 1266) Prognosis for oral cancer [154] MMP3 Urinary (n = 70) Diagnosis and prognosis for bladder cancer [155] MMP9 Tissues (n = 1266) Prognosis for oral cancer [154] MMP14 Tissues (n = 456) Prognosis for colorectal cancer [156] MMP16 Tissues (n = 375) Prognosis for gastric cancer [157] Effectors RHAMM Tissues (n = 383) Prognosis for large cell lung cancer [158] Tissues (n = 64) Prognosis for kidney cancer [159] Tissues (n = 33) Prognosis for ovarian cancer [160] Tissues (n = 223) Progno...…”

Section: Samples Potential Clinical Applications In Cancermentioning

confidence: 99%

“…High expression levels of HS signaled poor prognosis in patients with gastric carcinoma [131]. Higher levels of HA were associated with poor survival in patients with breast cancer [133], acute myeloid leukemia [134], and prostate cancer [132]. Elevated serum levels of HA can be a diagnostic biomarker for patients with prostate cancer [132], upper gastrointestinal cancers [136], and mesothelioma [139].…”

Section: Gags and Gps In Diagnosis And Prognosismentioning

confidence: 99%

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Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Wei

Huang

et al. 2020

IJMS

115

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The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of ECM remodeling can lead to tumorigenesis and cancer development by providing favorable conditions for tumor cells. Proteoglycans (PGs) and glycosaminoglycans (GAGs) are the major macromolecules composing ECM. They influence both cell behavior and matrix properties through direct and indirect interactions with various cytokines, growth factors, cell surface receptors, adhesion molecules, enzymes, and glycoproteins within the ECM. The classical features of PGs/GAGs play well-known roles in cancer angiogenesis, proliferation, invasion, and metastasis. Several lines of evidence suggest that PGs/GAGs critically affect broader aspects in cancer initiation and the progression process, including regulation of cell metabolism, serving as a sensor of ECM’s mechanical properties, affecting immune supervision, and participating in therapeutic resistance to various forms of treatment. These functions may be implemented through the characteristics of PGs/GAGs as molecular bridges linking ECM and cells in cell-specific and context-specific manners within the tumor microenvironment (TME). In this review, we intend to present a comprehensive illustration of the ways in which PGs/GAGs participate in and regulate several aspects of tumorigenesis; we put forward a perspective regarding their effects as biomarkers or targets for diagnoses and therapeutic interventions.

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Section: Samples Potential Clinical Applications In Cancermentioning

confidence: 99%

Section: Gags and Gps In Diagnosis And Prognosismentioning

confidence: 99%

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Wei

Huang

et al. 2020

IJMS

115

View full text Add to dashboard Cite

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“…Although HA and collagen expression in the TME are considered prognostic biomarkers, there are no/few studies examining serum concentrations of HA and type III collagen in patients with PC. Previous studies conducted in other malignancies have shown a negative correlation between serum HA and outcome and serum collagen fragments and outcome . The aim of this biomarker study was to investigate the clinical utility of serum HA and propeptide of type III collagen (PRO‐C3) in patients with PC.…”

Section: Introductionmentioning

confidence: 99%

Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

Chen

Willumsen

Dehlendorff

et al. 2019

Intl Journal of Cancer

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Hyaluronan (HA) and collagen are highly expressed in pancreatic cancer (PC) stroma. HA and collagen accumulation increase tumor interstitial fluid pressure, compromising blood flow and drug penetration. The aim of this biomarker study was to determine the clinical utility of serum HA and the propeptide of type III collagen (PRO‐C3) in patients with PC. A cohort from the Danish BIOPAC study (NCT03311776) including patients with histologically confirmed pancreatic ductal adenocarcinoma (n = 809), ampullary carcinoma (n = 44), distal biliary tract cancer (n = 31), chronic pancreatitis (n = 15), intraductal papillary mucinous neoplasm (n = 41), duodenal adenoma (n = 7) and no cancer (n = 25). Healthy controls were available for serum HA (n = 141) and PRO‐C3 (n = 8). The main outcome was overall survival (OS) of patients with PC in relation to pretreatment serum HA and PRO‐C3 levels. Patients with PC had higher baseline serum HA and PRO‐C3 than healthy subjects and patients with benign conditions. Pretreatment serum baseline HA and PRO‐C3 in patients with PC were associated with poorer survival and PRO‐C3 remained prognostic also after adjusting for age, performance status, stage, the presence of liver and peritoneum metastasis, and CA19‐9. Detection of HA and PRO‐C3 may be useful in differentiating between malignant and benign pancreatic conditions. Serum HA and PRO‐C3 were prognostic for OS in patients with PC.

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“…In addition, we confirmed that up-regulated UGDH nuclear or cytoplasmic expression was observed in stage I ACs compared with non-neoplastic bronchial epithelial cells. A recent study showed that the serum HA level was correlated with the metastasis and aggressiveness of tumors (1,35). There is no report on serum UGDH levels in cancer patients, but the expression levels may be elevated because overexpression of UGDH in tumor cells is detected.…”

Section: Discussionmentioning

confidence: 99%

<b>Clinicopathological and prognostic significance of nuclear UGDH localization in lung adenocar</b><b>cinoma</b>

et al. 2019

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This study aimed to clarify relationships among UDP-glucose-6 dehydrogenase (UGDH) expression, clinicopathological factors, and the prognosis of patients, and to determine the role of UGDH in lung adenocarcinoma (AC). Firstly, UGDH expression and localization in 126 lung AC tissues were immunohistochemically studied, and associations with clinicopathological parameters and patients' prognosis were evaluated. Secondly, serum UGDH levels were measured in 267 lung cancer patients and 100 healthy controls. Finally, the effects of UGDH knockdown by siRNA on migration and invasion abilities were analyzed. As a result, nuclear UGDH staining was significantly correlated with poorer differentiation, a larger tumor size, higher p-TNM stage, positive nodal metastasis, positive lymphatic invasion, and positive vascular invasion in lung AC patients. Nuclear UGDH-positive patients showed significantly poorer survival than nuclear UGDH-negative patients. Serum UGDH levels were especially higher in lung AC patients even in stage I than those in healthy controls. In lung AC cell lines, nuclear expression levels of UGDH were higher in LC-2/ad cells than in A549 cells. UGDH siRNA-treated LC-2/ad cells showed significantly decreased migration and invasion abilities, but no significant differences were observed in UGDH siRNA-treated A549 cells. These data indicate that UGDH expression and localization are an early sero-diagnostic marker in addition to a poor prognostic indicator in lung AC patients.

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Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

Cited by 9 publications

References 39 publications

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

<b>Clinicopathological and prognostic significance of nuclear UGDH localization in lung adenocar</b><b>cinoma</b>

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