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Tissue SIRT1 as Potentially Valuable Biomarkers in Gastric Cancer

Otsuka, Ryota; Morishita, Hiroki; Iida, Kei; Hayano, Koichi; Murakami, Kentaro; Endo, Satoshi; Toyozumi, Takeshi; Matsumoto, Yasunori; Kurata, Yoshiyuki; Kinoshita, Kazuya; Sasaki, Takuma; Iida, Shinichiro; Nishioka, Yuri; Matsubara, Hisahiro

doi:10.21873/anticanres.16297

Anticancer Res

2023

DOI: 10.21873/anticanres.16297

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Serum Versus Tissue SIRT1 as Potentially Valuable Biomarkers in Gastric Cancer

Ryota Otsuka

Hiroki Morishita

Kei Iida

et al.

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2024

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Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway

Belardi,

Pacifici,

Cosio

et al. 2024

Biomolecules

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Actinic keratosis (AK) is a precursor to invasive squamous cell carcinoma, making early diagnosis and treatment essential to prevent progression. Among available therapeutic options, nicotinamide (NAM) has shown potential in reducing AK progression. NAM is a precursor of nicotinamide adenine dinucleotide (NAD+), which activates sirtuin (SIRT)1, a protein with anti-cancer properties. Although the role of SIRT1 in AK is still debated, no data currently exist on the systemic modulation of this protein in AK. Therefore, this study aims to evaluate whether NAM, by increasing serum NAD+ levels, may promote SIRT1 activation in peripheral blood mononuclear cells (PBMCs) in AK patients. Thirty patients were enrolled and treated with NAM for 24 months. Hematological, biochemical, and skin condition assessments were conducted, alongside the measurement of SIRT1 and NAD+ levels. A decrease in basophils, monocytes, total cholesterol, and blood glucose levels was observed in the study group, along with a reduction in AK lesions. Notably, NAM treatment significantly enhanced serum NAD+ levels, and nuclear SIRT1 activity in PBMCs. In conclusion, NAM administration significantly reduced AK progression in a NAD+/SIRT1-dependent manner, supporting its role as a chemopreventive agent in AK management.

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Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway

Belardi,

Pacifici,

Cosio

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

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Serum Versus Tissue SIRT1 as Potentially Valuable Biomarkers in Gastric Cancer

Cited by 1 publication

References 0 publications

Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway

Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway

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