Serum <i>Wisteria floribunda</i> agglutinin‐positive Mac‐2 binding protein more reliably distinguishes liver fibrosis stages in non‐alcoholic fatty liver disease than serum Mac‐2 binding protein

Atsukawa, Masanori; Tsubota, Akihito; Okubo, Tomomi; Arai, Taeang; Nakagawa, Ai; Itokawa, Norio; Kondo, Chisa; Kato, Kazúo; Hatori, Tsutomu; Hano, Hiroshi; Oikawa, Tsunekazu; Emoto, Naoya; Abe, Masanori; Kage, Masayoshi; Iwakiri, Katsuhiko

doi:10.1111/hepr.13046

Cited by 15 publications

(14 citation statements)

References 28 publications

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“…Differences in measurement times may have caused errors in the results and the low accuracy of serum M2BPGi-based fibrosis diagnosis in our study (median [range] of M2BPGi was 0.6 [0.13-5.90]]. In a Japanese study examining M2BPGi in NAFLD [27], the serum M2BPGi COI was 0.85 (0.22-11.32), slightly higher than the present data; however, another study showed different serum M2BPGi COIs for non-HCC and HCC NAFLD (1.1 ± 0.7 and 3.1 ± 3.2, respectively) [4]. Fourth, this study was retrospective in nature, and, as TE was not conducted for all patients, TE data could not be analyzed.…”

Section: Discussionmentioning

confidence: 69%

Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

et al. 2021

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Section: Discussionmentioning

confidence: 69%

Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

et al. 2021

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“…Several unique studies have provided the means for a non‐invasive screening of liver fibrosis in HIV/HCV coinfection, using the macrophage activation marker soluble CD163 or surface‐enhanced laser desorption ionization time‐of‐flight mass spectrometry . In the present study we focused on WFA + ‐M2BP, which has multibranching and sialylated N‐glycans, and is well known as a marker of liver fibrosis for use in various types of liver disease, including hepatitis B, hepatitis C, and non‐alcoholic fatty liver disease . In liver surgery, Ishii et al .…”

Section: Discussionmentioning

confidence: 99%

Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein as a predictive marker of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients

Takatsuki

Yamasaki

Natsuda

et al. 2020

Hepatology Research

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Aim: In human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfected patients, the progression of liver failure is reported to be more aggressive than that in HCV monoinfected patients. Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA + -M2BP) is well recognized as a liver fibrosis glycobiomarker with a unique fibrosis-related glycoalteration. We analyzed HIV/HCV coinfected patients' M2BP levels as a possible marker for predicting liver fibrosis.Methods: M2BP was measured in 31 HIV/HCV coinfected patients, and we analyzed the correlation between WFA + -M2BP and several markers of fibrosis, liver function, and tumor markers. We compared the WFA + -M2BP levels in HIV/HCV coinfected patients with those of HCV mono-infected patients by performing a propensity score matching analysis.Results: In the HIV/HCV coinfected patients, the serum level of WFA + -M2BP was well correlated with the markers type IV collagen, hyaluronic acid, and alpha-fetoprotein, but not protein induced by vitamin K absence-II. In the propensity score matching with HCV mono-infected patients, the WFA + -M2BP levels were significantly higher in the HIV/HCV coinfected patients compared with the levels in the HCV mono-infected patients. Conclusion:In conclusion, WFA + -M2BP might be a feasible predictive marker of fibrosis in HIV/HCV coinfected patients.

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“…As an index of insulin resistance, the homeostasis model assessment-insulin resistance (HOMA-IR) was calculated using the following equation: HOMA-IR = fasting insulin (μU/mL) × plasma glucose (mg/dL)/405 [27]. Hyaluronic acid [28], type IV collagen 7s domain [29, 30], and Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA + -M2B) [30–32], all of which have been reported as useful liver fibrosis markers in NAFLD, were measured. In addition, the fibrosis scores such as the FIB-4 index [33] and NAFLD fibrosis scorer (NFS) [34] were calculated, as reported previously.…”

Section: Methodsmentioning

confidence: 99%

Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease

et al. 2019

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Although the presence of nonalcoholic fatty liver disease (NAFLD) is known to be related to subclinical atherosclerosis, the relationship between the severity of NAFLD and subclinical atherosclerosis is not clear. This study aimed to clarify the factors related to subclinical arteriosclerosis, including the histopathological severity of the disease and PNPLA3 gene polymorphisms, in NAFLD patients. We measured brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness in 153 biopsy-proven NAFLD patients. The baPWV values were significantly higher in the advanced fibrosis group than in the less advanced group (median, 1679 cm/s vs 1489 cm/s; p = 5.49×10−4). Multiple logistic regression analysis revealed that older age (≥55 years) (p = 8.57×10−3; OR = 3.03), hypertension (p = 1.05×10−3; OR = 3.46), and advanced fibrosis (p = 9.22×10−3; OR = 2.94) were independently linked to baPWV ≥1600 cm/s. NAFLD patients were categorized into low-risk group (number of risk factors = 0), intermediate-risk group (= 1), and high-risk group (≥2) based on their risk factors, including older age, hypertension, and biopsy-confirmed advanced fibrosis. The prevalence of baPWV ≥1600 cm/s was 7.1% (3/42) in the low-risk group, 30.8% (12/39) in the intermediate-risk group, and 63.9% (46/72) in the high-risk group. Non-invasive liver fibrosis markers and scores, including the FIB-4 index, NAFLD fibrosis score, hyaluronic acid, Wisteria floribunda agglutinin positive Mac-2-binding protein, and type IV collagen 7s, were feasible substitutes for invasive liver biopsy. Older age, hypertension, and advanced fibrosis are independently related to arterial stiffness, and a combination of these three factors may predict risk of arteriosclerosis in NAFLD patients.

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Serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein more reliably distinguishes liver fibrosis stages in non‐alcoholic fatty liver disease than serum Mac‐2 binding protein

Abstract: This head-to-head comparison suggests that WFA -M2BP is superior to M2BP for distinguishing liver fibrosis stages in NAFLD patients. A marked discrepancy between the two biomarkers may be indicative of advanced NAFLD (UMIN000023286).

Cited by 15 publications

References 28 publications

Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein as a predictive marker of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients

Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease

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