SERUM IgA ANTIBODIES TO EPSTEIN-BARR VIRUS CAPSID ANTIGEN PRECEDING SYMPTOMS OF NASOPHARYNGEAL CARCINOMA

Ho, Helen; Kwan, H. C.; Ng, Margaret H.L.; de-Thé, G

doi:10.1016/s0140-6736(78)91220-5

Cited by 60 publications

(23 citation statements)

References 8 publications

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“…These results are similar to those reported by Ho et al [5] and Lanier et al [6] in their retrospective studies. They found that IgA/VCA antibody was detectable 22-72 months before clinical diagnosis was made in the advanced stages.…”

Section: Discussionsupporting

confidence: 93%

Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Zeng

Zhong²,

Li³

et al. 1983

Intervirology

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Serological mass surveys were carried out in Zangwu County, China, using an immunoenzymatic test. 3,533 persons were found to have Epstein-Barr virus (EBV) IgA/VCA antibody among 148,029 persons age 30 years and older who were tested during 1978–1980. Among the IgA/VCA antibody-positive persons, 55 nasopharyngeal carcinoma (NPC) cases were detected. Follow-up studies were carried out yearly on the IgA/VCA antibody-positive persons for 1–3 years, and 32 additional NPC patients were diagnosed. IgA/VCA antibody was detected 8–30 months (average, 13 months) prior to the clinical diagnosis of stage I NPC. There was no marked difference in geometric mean titers of IgA/VCA antibody between the period before onset of NPC and after diagnosis at stage I, but antibody titers were higher during stages II-IV. The NPC detection rates for all persons tested serologically and for IgA/VCA antibody-positive persons, respectively, was 2- and 82-fold the annual incidence of NPC in the general population of the same age group. These data further indicate that serological testing is valuable for the diagnosis of NPC, especially in its early stages, and that EBV may play an important role in the development of NPC.

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Section: Discussionsupporting

confidence: 93%

Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Zeng

Zhong²,

Li³

et al. 1983

Intervirology

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“…A high IgA VCA titer often precedes symptomatic onset of NPC by 6 to 41 months. 19,20 However, in those studies, the pathologic status of the nasopharynx was not specified. In this study, we confirm that the IgA against EBV VCA is elevated in the preinvasive stage and may be a useful screening tool for preinvasive lesions.…”

Section: Teomentioning

confidence: 99%

Nasopharyngeal carcinoma in situ (NPCIS)—pathologic and clinical perspectives

Pak¹,

To²,

Lo³

et al. 2002

Head & Neck

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“…Our patient was observed to have tumour invasion into the left foramen ovale, but had no manifest symptoms from this 15 21…”

Section: Discussionmentioning

confidence: 72%

Large retropharyngeal abscess: a case of mistaken identity

et al. 2016

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We report an unusual case of nasopharyngeal carcinoma (NPC), presenting initially as a retropharyngeal collection. We discuss the investigation, diagnosis and management of NPC and furthermore review the literature of NPC, emphasising the varied presentation. A 44-year-old Caucasian male ex-smoker presented with a 10-day history of a painless left-sided neck lump; progressive dysphagia and unintentional weight loss. Examination demonstrated a large left posterior pharyngeal swelling with soft palatal effacement, confirmed on nasoendoscopy. A CT scan revealed a fluid collection in the retropharyngeal space, which partially occluded the nasopharynx, and numerous satellite lesions were identified along with cervical lymphadenopathy. The suspected abscess was drained in theatre and nasopharyngeal biopsies were taken. These revealed Epstein-Barr virus-positive NPC. Staging investigations revealed a T4N2M0l carcinoma. Treatment consisted of radical chemoradiation therapy with curative intent. NPC is known for its varied and late presentation, and is an important condition to be aware of when considering a differential diagnosis of pharyngeal masses.

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SERUM IgA ANTIBODIES TO EPSTEIN-BARR VIRUS CAPSID ANTIGEN PRECEDING SYMPTOMS OF NASOPHARYNGEAL CARCINOMA

Cited by 60 publications

References 8 publications

Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Nasopharyngeal carcinoma in situ (NPCIS)—pathologic and clinical perspectives

Large retropharyngeal abscess: a case of mistaken identity

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SERUM IgA ANTIBODIES TO EPSTEIN-BARR VIRUS CAPSID ANTIGEN PRECEDING SYMPTOMS OF NASOPHARYNGEAL CARCINOMA

Cited by 60 publications

References 8 publications

Follow-Up Studies on Epstein &ndash; Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Follow-Up Studies on Epstein &ndash; Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Nasopharyngeal carcinoma in situ (NPCIS)—pathologic and clinical perspectives

Large retropharyngeal abscess: a case of mistaken identity

Contact Info

Product

Resources

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Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China

Follow-Up Studies on Epstein – Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China