2016
DOI: 10.1016/j.atherosclerosis.2016.05.020
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Serum IgE levels are associated with coronary artery disease severity

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Cited by 42 publications
(32 citation statements)
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“…6 Elevated serum IgE can be caused by allergic reactions, infections, and other immune conditions, including the hyper-IgE syndrome, 7 a rare primary immunodeficiency disease characterized by recurrent skin and pulmonary abscesses and extremely elevated IgE serum levels. In addition, IgEs might be increased in acute myocardial infarction, stable and unstable angina, further correlating with plaque destabilization and severity of acute myocardial infarction, 1,8 and elevated IgE levels may be a risk factor for increased cardiovascular mortality. 9 Increased IgE Levels: Cause or Consequence of Acute Coronary Events?…”
Section: Causes Of Ige Releasementioning
confidence: 99%
“…6 Elevated serum IgE can be caused by allergic reactions, infections, and other immune conditions, including the hyper-IgE syndrome, 7 a rare primary immunodeficiency disease characterized by recurrent skin and pulmonary abscesses and extremely elevated IgE serum levels. In addition, IgEs might be increased in acute myocardial infarction, stable and unstable angina, further correlating with plaque destabilization and severity of acute myocardial infarction, 1,8 and elevated IgE levels may be a risk factor for increased cardiovascular mortality. 9 Increased IgE Levels: Cause or Consequence of Acute Coronary Events?…”
Section: Causes Of Ige Releasementioning
confidence: 99%
“…In this issue of Atherosclerosis, Guo et al [4] measured total serum IgE concentrations in 708 consecutive patients admitted to coronary angiography laboratory, and assessed the severity of coronary artery disease by the number of diseased vessels showing !50% diameter stenosis and quantified by Gensini scores. They found that total serum IgE levels were significantly increased in patients with multi-vessel disease compared to those with singlevessel disease, were independent predictors for an increased risk of multi-vessel disease, and contributed to discriminating coronary artery disease severity independently of traditional cardiovascular risk factors.…”
mentioning
confidence: 99%
“…When IgE levels were above 200 kU/L, the incidence of non-fatal myocardial infarction was even higher. 4 In another prospective clinical study [8], 55 patients with acute myocardial infarction, unstable angina and stable angina pectoris were compared with 15 healthy controls. IgE levels were serially measured on days 1, 3, 7, 21 after admission and 3 months later in the acute myocardial infarction and unstable angina groups and only once in the stable angina pectoris and healthy controls.…”
mentioning
confidence: 99%
“…Further studies by others indicated that high serum IgE levels might be related to myocardial infarction, coronary arterial disease, cerebral arterial stenosis, coronary artery aneurysms and other CVDs 9 - 14 . Furthermore, we and our colleagues found that serum IgE levels were significantly higher in multi-vessel disease compared to single-vessel disease (61.80 vs. 32.45 kU/L, p = 0.003) independently of traditional cardiovascular risk factors, indicating that serum IgE levels might be associated with coronary artery disease severity 15 . Another study reported by us showed that IgE was able to stimulate arterial cell apoptosis and cytokine expression and promote atherosclerosis by enhancing Na+/H+ exchanger 1 (NHE1) activity on macrophages 16 .…”
Section: Introductionmentioning
confidence: 57%