Serum IgE Levels in 622 Persons with Human Immunodeficiency Virus Infection: IgE Elevation with Marked Depletion of CD4<sup>+</sup>T-Cells

Lucey, Daniel R.; Zajac, Robert A.; Melcher, Gregory P.; Butzin, Clifford A.; Boswell, R N

doi:10.1089/aid.1990.6.427

Cited by 66 publications

(27 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High serum IgE in individuals with AIDS were seen at the beginning of the epidemic and confirmed years later by other studies (63)(64)(65)(66)(67)(68)(69). Some studies have found a relationship between high IgE levels and CD4 + T lymphocyte count < 300 cells/ mm 3 (64)(65)67). Association between increased IgE levels and faster progression to AIDS was observed by Rancinan et al (69) in 1998.…”

Section: Discussionsupporting

confidence: 53%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

show abstract

Section: Discussionsupporting

confidence: 53%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

show abstract

“…Studies in various geographical regions have reported elevated serum IgE concentrations in HIV-1-infected adults [21, 28, 29, 30, 31, 32, 33]and children [22, 23, 24, 25, 26, 27]. High IgE levels have been associated with disease progression in both children [22, 23, 24, 25, 26, 27]and adults [33, 34, 35, 36, 37, 38, 39, 40, 41, 42]and have been suggested as a marker of poor prognosis in these patients.…”

Section: Th1 and Th2 Responses In Hiv-1 Infectionmentioning

confidence: 99%

“…IL-4 and IL-13 induced by these proteins from FcεRI + cells might also interact with specific receptors on B cells, in turn inducing ε germline mRNA expression and causing the switch to the IgE isotype. This sequence of events, schematically represented in figure 2, could help explain the elevated IgE levels in HIV-1-infected children and adults [21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33]. …”

Section: Closing Remarksmentioning

confidence: 99%

“…While there is no apparent relation between these two disorders, a number of features of HIV infection suggest that hypersensitivity arises in these patients. For example, the Th1 and Th2 cytokine profile is deranged in HIV-1 infection because of a shift towards Th2 cytokines [13, 14, 15, 16, 17, 18, 19, 20, 21], and serum IgE levels are raised in HIV-1-infected children [22, 23, 24, 25, 26, 27]and adults [21, 28, 29, 30, 31, 32, 33]. Moreover, HIV-1-infected patients have enhanced symptoms of allergic disorders [34, 35, 36]and HIV-1 antigens induce histamine release from basophils [4, 37, 38].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Are Mast Cells MASTers in HIV-1 Infection?

Marone

Paulis

Florio

et al. 2001

Int Arch Allergy Immunol

View full text Add to dashboard Cite

HIV-1 gp120 interacts with IgE V_H3⁺ on the surface of human basophils and mast cells (FcΕRI⁺ cells), acting as a viral immunoglobulin superantigen. gp120 from different clades induces mediator release from FcΕRI⁺ cells. gp120 also induces IL-4 and IL-13 synthesis in human basophils. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human FcΕRI⁺ cells. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells, interacting with CCR3. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human FcΕRI⁺ cells could be infected in vitro by M-tropic HIV-1 strains.

show abstract

“…Psoriasis in HIV patients presents more severely and is associated with a worse outcome [3]. The skin cytokine expression in HIV patients is altered [4] and elevated levels of IgE, a hallmark of atopic disorders, were observed in HIVinfected adults and children [5][6][7]. Studies have shown that HIV glycoproteins can act as viral superantigens and contribute to the release of IgE and histamine, leading to a shift of the T cell response towards the Th2 phenotype [8].…”

Section: Introductionmentioning

confidence: 99%

Hyper IgE, Dermatitis and Staphylococcus aureus in an HIV-Positive Man

Shiu¹,

Wang

Ellis³

et al. 2015

J Infect Dis Ther

View full text Add to dashboard Cite

Serum IgE Levels in 622 Persons with Human Immunodeficiency Virus Infection: IgE Elevation with Marked Depletion of CD4⁺T-Cells

Cited by 66 publications

References 11 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Are Mast Cells MASTers in HIV-1 Infection?

Hyper IgE, Dermatitis and Staphylococcus aureus in an HIV-Positive Man

Contact Info

Product

Resources

About

Serum IgE Levels in 622 Persons with Human Immunodeficiency Virus Infection: IgE Elevation with Marked Depletion of CD4+T-Cells

Cited by 66 publications

References 11 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Are Mast Cells MASTers in HIV-1 Infection?

Hyper IgE, Dermatitis and Staphylococcus aureus in an HIV-Positive Man

Contact Info

Product

Resources

About

Serum IgE Levels in 622 Persons with Human Immunodeficiency Virus Infection: IgE Elevation with Marked Depletion of CD4⁺T-Cells