SERUM IgE LEVELS IN PATIENTS WITH LIVER DISEASE

Ra, Joske; Kj, Turner; Bp, Murphy

doi:10.5694/j.1326-5377.1976.tb130385.x

Cited by 17 publications

(10 citation statements)

References 7 publications

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“…Elevated serum IgE concentrations in patients with liver damage have been previously reported but data on this setting are far from being conclusive since studies mixed patients not only with different aetiologies but also with very different stages of liver disease [37,[40][41][42][43][44][45], The present study analysed patients with advanced chronic liver disease, meaning that they may be considered homogeneous with regard to the severity ofthe disease. In that situation, only alcoholic patients seemed to demon-strate increased IgE levels, particularly when compared with hepatitis virus-related cirrhotics.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the same study 52-3% (11/21) of patients with non-alcoholic liver disease also presented raised IgE values so no clear difference was apparent among the various types of liver disorder studied. Nevertheless, the group of non-alcoholic patients investigated by the authors consisted mainly of cases of acute hepatitis (11/21) which area well-known cause of increased serum IgE levels [37,[40][41][42]45] and only included five cases of liver cirrhosis. Along the same line, Levo and Shalit [41] reported an apparent high prevalence of elevated serum IgE in non-alcoholic liver cirrhosis (15/ 49 patients, 32-6%) but this figure may be misleading since serum IgE levels higher than 100 IU/ml were considered elevated so that 25%) of control subjects had also raised IgE values, the difference being not significant.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on serum IgE levels in this setting are scarce and not well standardized [37][38][39][40][41][42][43][44][45] so the possible role of this particular immunoglobulin in liver diseases might have been underestimated. In view ofthe foregoing, the present study was aimed to analyse serum IgE levels in an homogeneous group of patients with advanced liver cirrhosis, evaluating their relationship with several aetiological, clinical and functional parameters (including phagocytie activity of Kupffer cells).…”

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Serum IgE levels in liver cirrhosis.

Vidal

Gonzalez-Quintela²,

Millán³

et al. 1994

Clin Experimental Allergy

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Hypergammaglobulinemia is a well-known feature of liver cirrhosis, but studies on serum IgE in this setting are limited. The present study evaluates serum IgE concentration in a group of cirrhotic patients and examines their relationship with aetiological, clinical and analytical parameters (including liver function tests and hepatic phagocytic activity). The presence of specific IgE against common dietary antigens was also investigated. Total serum IgE was determined by enzyme immunoassay (EIA) in 52 cirrhotics (27 alcoholic and 25 non-alcoholic, including eight virus B and seven virus C-related cirrhosis, three primary biliary cirrhosis, three cryptogenic, three haemochromatosis and one Wilson's disease) and 34 healthy subjects (used as controls). Serum IgE (IU/ml) in controls was not significantly different from that of cirrhotic patients (median 42, range 2-726 vs median 86, range 2- > 1000, respectively) (P = NS). However, serum IgE among alcoholics (median 199, range 19- > 1000) was higher than that of controls (P < 0.001), virus B-related cirrhotics (median 25, range 3- > 1000) (P < 0.05), virus C-related cirrhotics (median 47, range 2-170) (P < 0.05), or non-alcoholic cirrhotics as a whole (median 23, range 2- > 1000) (P < 0.01). High IgE levels (> or = 170 IU/ml) were detected in 55.5% of alcoholics compared with only 12% of non-alcoholic cirrhotics (P < 0.01). Moreover, IgE levels were very high (> 1000 IU/ml) in six patients of the alcoholic group (22.2%) compared with only one non-alcoholic patient (4%).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum IgE levels in liver cirrhosis.

Vidal

Gonzalez-Quintela²,

Millán³

et al. 1994

Clin Experimental Allergy

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“…As far as acute liver injury is concerned, there are reports of increased serum IgE levels in both acute hepatitis A and B, which may decrease during recovery [1,2]. Similarly, serum IgE values have been found to be elevated in untreated chronic active hepatitis of undefined aetiology [7]. However, the situation is different in chronic advanced hepatic disease (liver cirrhosis).…”

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confidence: 99%

Increased serum IgE in alcohol abusers

González‐Quintela

Vidal

Gudé³

et al. 1995

Clin Experimental Allergy

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“…Another group of male alcsholics with a mean age of Abbreviations: AP = alkaline phosphatase, ALAT = alanine aminotransferase, ASAT = aspartate aminotransferase, LD = lactate dehydrogenase, y-GT = y-glutamyltransferase. 44 years (range 34-53) were followed during 16 days as inpatients at the Department of Psychiatry, University Hospital, Uppsala, after a period of alcohol abuse of 3- 16 weeks. The average ethanol consumption in the week prior to admission was 380 g/day (range 200-600).…”

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Increased Total Serum IgE in Alcoholics

Hällgren

Lundin

1983

Journal of Internal Medicine

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Total serum IgE concentrations were measured in 106 male alcoholics with current alcohol abstinence of varying duration. The influence of smoking habits and clinical atopy on IgE levels was considered. The majority (91%) of the alcoholics were smokers and 26 % suffered from possible clinical atopy. The geometric mean IgE in non-atopic, smoking alcoholics was 42 kU/I and significantly higher than the mean IgE level, 19 kU/I, in age-matched, smoking, non-atopic male participants in a general health survey @<0.001). The IgE levels declined with the length of the alcohol abstinence period. Alcoholics, serially followed after a heavy drinking spree, showed a uniform pattern of declining IgE levels during a fortnight of abstinence (p <0.001).No link was noted between total IgE levels and the extent of liver affection as estimated by various serum variables (bilirubin, aminotransferases, 'y-GT, IgG, IgA and IgM) or galactose tolerance test. The increased IgE levels in alcoholics are suggested to reflect an influence of ethanol on T lymphocytes regulating the IgE synthesis. Such a proposed effect of ethanol on cellular immunity may contribute to certain organic alcohol diseases, but does not appear to influence the frequency of clinical atopy, being similar in our patient group and in the general population of the same geographic area.

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SERUM IgE LEVELS IN PATIENTS WITH LIVER DISEASE

Cited by 17 publications

References 7 publications

Serum IgE levels in liver cirrhosis.

Serum IgE levels in liver cirrhosis.

Increased serum IgE in alcohol abusers

Increased Total Serum IgE in Alcoholics

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