Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings

Lander, Flemming; Meyer, H.; Norn, S.

doi:10.1007/s000110050748

Cited by 35 publications

(13 citation statements)

References 26 publications

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“…The data on outdoor molds (eg, Alternaria species and basidiomycetes) purportedly causing allergic rhinitis are indirect and conflicting. [11][12][13] Studies attempting to correlate indoor molds with symptomatic allergic rhinitis are even more problematic because of such methodological uncertainties as lack of quantitative mold sampling [14][15][16] and inclusion of upper respiratory tract infections. 17 Published reports document mold sensitivity in some children and adults with atopic dermatitis.…”

Section: The Relationship Of Molds To Allergy and Asthmamentioning

confidence: 99%

The medical effects of mold exposure

Bush

Portnoy

Saxon³

et al. 2006

Journal of Allergy and Clinical Immunology

357

214

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Section: The Relationship Of Molds To Allergy and Asthmamentioning

confidence: 99%

The medical effects of mold exposure

Bush

Portnoy

Saxon³

et al. 2006

Journal of Allergy and Clinical Immunology

357

214

View full text Add to dashboard Cite

“…Logistic regression was also used for the other analysis in order to check for potential confounders. In the final multiple logistic regression analysis, subjects who in the questionnaire stated themselves as exposed to known occupational asthma-associated allergens were excluded, but not subjects exposed to mould at their workplace, since the mechanism of the latter seems to be a nonspecific inflammatory response (Taskinen et al 2002;Lander et al 2001). All analyses were carried out with Stata v 10.1 (StataCorp, College Station, TX, USA).…”

Section: Statisticsmentioning

confidence: 99%

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Graff¹,

Fredrikson²,

Jonsson³

et al. 2011

Int Arch Occup Environ Health

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Non-sensitising air pollution at workplaces and adult onset asthma -2- AbstractPurpose This case-control study was undertaken to elucidate the controversy concerning whether low level, long-term exposure to non-sensitising air pollution at workplaces may cause asthma.Methods A case-control study of 192 adult onset asthma cases aged 20 -65 years and 323 controls was conducted in the southeast of Sweden. Cases were identified from computerised registers from the region, diagnosed 2000-2004 and diagnoses were confirmed via medical files. Referents were randomised from the population register of the region. Exposure was monitored by a 16-page questionnaire. Special attention was devoted to identifying and in the final analyses excluding subjects exposed to sensitising agents.Results Three years or more of occupational exposure to air pollution from dust, smoke, fumes or vapours before the year of diagnosis by analyses adjusting for age yielded an increased risk for asthma (OR =2.3, 95 % CI 1.2-4.2) in males, while in females no risk was seen. In a multiple logistic regression analysis in males without allergy in childhood, a significant risk was seen (OR=2.8, 95 % CI 1.07 -7.4), when subjects exposed to identified allergens were excluded. In females no excess risk was observed from occupational air pollution. ConclusionThe results of this study support an association between occupational exposure to low level non-sensitising air pollution and adult onset asthma in males.Non-sensitising air pollution at workplaces and adult onset asthma -3-

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“…[10][11][12] IgE sensitization to fungi has been shown to be associated with building-related symptoms in individuals working in damp and moldy buildings. 30 The prevalence of IgE positivity to molds was 23% in our patients with occupational rhinitis, and, interestingly, almost all of the patients with IgE positivity to molds had atopic tendencies. This is compatible with the suggestion that IgE sensitization to molds may occur in atopic individuals as part of polysensitization.…”

Section: Discussionmentioning

confidence: 93%