Serum IGF1 and insulin levels in girls with normal and precocious puberty

Abstract

Objective: IGF1 plays an important role in growth and metabolism during puberty. IGF1 levels are increased in girls with central precocious puberty (CPP). However, the relationship with insulin before and during gonadal suppression is unknown. In addition, the influence of the exon 3-deleted GH receptor gene (GHRd3) on IGF1 levels was evaluated. Design: Nine hundred and eleven healthy and 23 early pubertal girls (15 with CPP) participated and were evaluated by dual-energy X-ray absorptiometry (DXA) scans, fasting and oral glucose-stimulated insulin levels, IGF1 levels, and GHR genotyping. Fifteen girls with early puberty (13 with CPP) were treated with GNRH agonists and reevaluated after 3 and 12 months. Results: IGF1 and insulin levels were higher in girls with CPP compared with healthy controls after adjustment for age, bone age, and breast development (all P%0.02). IGF1 levels were only significantly positively correlated with insulin levels in girls with CPP at baseline (P%0.03). During gonadal suppression, changes in IGF1 levels were inversely associated with changes in insulin levels (PZ0.04). The GHRd3/d3 genotype was associated with significantly higher IGF1 levels (PZ0.01) but not with earlier pubertal timing in healthy girls. The distribution of the GHRd3 genotypes among girls with CPP did not differ significantly from healthy girls (PZ0.2). Conclusion: The increased IGF1 and insulin levels in girls with CPP may be causally interrelated. In addition, the GHRd3 allele positively influences IGF1 levels in a copy number-response relationship but not pubertal timing in healthy girls. European Journal of Endocrinology 166 903-910

BMI percentile-for-age overestimates adiposity in early compared with late maturing pubertal children

“…Blood samples were clotted, centrifuged, and serum was stored at K20 8C until hormone analyses were performed. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol (E 2 ), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) levels were measured by commercially available immune-assays as previously published (4,8,34,35).…”

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis

“…IGF-1 is a critical regulator of development; yet, circulating levels of IGF-1 levels are highly variable during puberty (range: from ∼100 to 800 ng/mL) (Bidlingmaier et al 2014;Sorensen et al 2012). In children with short stature, the prevalence of primary IGF-1 deficiency reaches 20 %.…”

“…Levels of circulating IGF-1 can increase several folds during this period compared to pre-adolescent levels. Yet, this increase is highly variable (Edouard et al 2009;Sorensen et al 2012). There is increasing experimental and clinical evidence that alterations in IGF-1 levels during development regulate multiple aspects of the aging process and affect the incidence of multiple age-related diseases (Sadagurski et al 2015;Sonntag and Csiszar 2012).…”

Pubertad precoz: no solo una cuestión de edad

“…En contraste, un polimorfismo común del receptor de GH con la exclusión del exón 3 (alelo GHRd3) se ha asociado recientemente con el aumento de los niveles de IGF-1 e inicio temprano de los signos clínicos y bioquímicos de la pubertad en los varones (41) . Se ha evaluado estas acciones en niñas con PPC, encontrando que el aumento de los niveles de IGF-1 e insulina en niñas con PPC puede estar causalmente relacionados entre sí; y que además, el alelo GHRd3 influye positivamente en los niveles de IGF-1, pero no con el momento de inicio de la pubertad en niñas sanas (42) .…”