Serum IgG Concentrations in Adult Patients Experiencing Virus-Induced Severe Asthma Exacerbations

Verduyn, Morgane; Botto, Guillaume; Jaubert, Julien; Lier, Clément; Flament, Thomas; Guilleminault, L.

doi:10.1016/j.jaip.2018.12.028

Cited by 13 publications

(8 citation statements)

References 39 publications

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“…However, in our mouse models, the OVA-specific serum IgE antibody levels were comparable in the eosinophilic (Alum/OVA) and neutrophilic (CFA/OVA) asthma groups (Fig 1F). Furthermore, and in line with clinical data [32,33], the antigen-specific serum IgG and IgG1 antibody levels were significantly higher in the eosinophilic than the neutrophilic asthma endotype (Fig 1F). No difference was observed for OVA-specific IgG2b and IgG2c antibody Neutrophilic and eosinophilic asthma can successfully be modeled in mice.…”

Section: Adjuvant-induced Mouse Models Of Asthma Endotypessupporting

confidence: 84%

Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models

Özkan

Eskiocak²,

Wingender

2021

PLoS ONE

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Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to the cells recruited to the airways and the related pathology. Eosinophilic asthma is the treatment-responsive endotype, which is mainly associated with allergic asthma. Neutrophilic asthma is a treatment-resistant endotype, affecting 5–10% of asthmatics. Although eosinophilic asthma is well-studied, a clear understanding of the endotypes is essential to devise effective diagnosis and treatment approaches for neutrophilic asthma. To this end, we directly compared adjuvant-induced mouse models of neutrophilic (CFA/OVA) and eosinophilic (Alum/OVA) asthma side-by-side. The immune response in the inflamed lung was analyzed by multi-parametric flow cytometry and immunofluorescence. We found that eosinophilic asthma was characterized by a preferential recruitment of interstitial macrophages and myeloid dendritic cells, whereas in neutrophilic asthma plasmacytoid dendritic cells, exudate macrophages, and GL7+ activated B cells predominated. This differential distribution of macrophage and dendritic cell subsets reveals important aspects of the pathophysiology of asthma and holds the promise to be used as biomarkers to diagnose asthma endotypes.

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Section: Adjuvant-induced Mouse Models Of Asthma Endotypessupporting

confidence: 84%

Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models

Özkan

Eskiocak²,

Wingender

2021

PLoS ONE

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“…A decrease in innate and adaptive immunity during childhood, especially in infancy, has been found to increase the susceptibility to viral respiratory infections, especially among those who are at increased risk of asthma [19]. A case-control study performed in asthmatic children aged two to 17 years in 2007 detected one or more virus-positive respiratory specimens in 63% of children with asthma during acute exacerbation and 23% of children with well-controlled asthma [20]. Other respiratory viruses detected in respiratory samples of asthmatic children include enterovirus, coronavirus, metapneumovirus, parainfluenza virus, and bocavirus [21,22].…”

Section: Resultsmentioning

confidence: 99%

Vulnerability for Respiratory Infections in Asthma Patients: A Systematic Review

Sharma¹,

Tasnim²,

Agadi³

et al. 2022

Cureus

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Asthma is a non-communicable and long-term condition affecting children and adults. The air passages in the lungs become narrow due to inflammation and tightening of the muscles around the small airways. Symptoms of asthma are intermittent and include cough, wheeze, shortness of breath, and chest tightness. Asthma is very often underdiagnosed and under-treated in many regions, especially in developing countries. While many studies show that viral infections can precipitate asthmatic attacks, very few studies have been conducted to see if history or current asthmatic attack increases the risk of viral infections. Our study aims to determine the predisposition of asthmatics to develop various viral infections and susceptibility toward certain viruses that cause upper respiratory tract infections.We performed a literature review of both published and unpublished articles. We included case reports, case series, reviews, clinical trials, cohort, and case-control studies, written only in English. Commentaries, letters to editors, and book chapters were excluded. Our initial search yielded 948 articles, of which 826 were rejected either because they were irrelevant or because they did not meet our inclusion criteria. We finally screened 122 abstracts and identified 24 relevant articles.People with a history of asthma have an abnormal innate immune response, making them potentially slower in clearing the infection and susceptible to both infections and virus-induced cell cytotoxicity. Also, in these studies, deficiencies in the interferon alpha response of peripheral blood mononuclear cells and plasmacytoid dendritic cells have been observed in asthmatics, both adults and children. Asthmatics with a viral infection usually present with an acute exacerbation of asthma, represented by dyspnea and cough, with other prodromal symptoms including vomiting and general malaise.The review includes an update on the relevance of dysregulated immune pathways in causing viral infections in asthmatic populations. It focuses on the evidence to suggest that people with asthma are at increased risk of viral infection, and viral infections in turn are known to precipitate and worsen the asthmatic status, making this a vicious cycle. The authors also suggest that further studies be undertaken to elucidate the pathophysiology and identify the critical therapeutic steps to break this vicious cycle and improve the quality of life for people with asthma.

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“…The researchers found three variants of the HRV: HRV-A, HRV-B, and HRV-C, with HRV-C being the most virulent for severe asthma exacerbations [15]. Other studies conducted in Japan, France, and Australia have also identified rhinovirus as the most common viral culprit for asthma exacerbations [28,[60][61][62]. White blood cells and neutrophil counts were significantly higher in patients with all HRV variants versus those who were negative for HRV (12.38 ± 5.13 vs. 10.77 ± 4.87 and 64.70 ± 20.27 vs. 56.44 ± 21.95, respectively) [15].…”

Section: Rhinovirusmentioning

confidence: 99%

“…Zheng et al [15] conducted one of the numerous studies that demonstrated that human rhinovirus (HRV) was the most common viral microbe to induce an asthma exacerbation in children [60][61][62]. Zheng and colleagues collected data from 143 inpatient children with asthma exacerbations, 131 outpatients, including 88 patients with asthma exacerbations, and 43 controls with stable asthma [15].…”

Section: Rhinovirusmentioning

confidence: 99%

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Howard

Orhurhu

Huang

et al. 2019

Curr Allergy Asthma Rep

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Purpose of Review Asthma is a chronic respiratory condition with increasing domestic and worldwide prevalence that burdens individuals and the healthcare system with high costs associated with long-term treatments and acute emergency room (ER) visits. It can be triggered by ambient microbes, including bacteria, viruses, and fungi. In this review, we examine the outcomes of asthma patients in relation to environmental exposures to ambient microbe products, focusing on whether exposure leads to asthma development from birth to childhood and if particular microbes are associated with worsened asthma exacerbations. Recent Findings Bacterial endotoxin is more prominent in homes with pets and may cause cytokine cascades that lead to asthma exacerbation. However, some studies have demonstrated a protective effect with early exposure. Patients with positive Aspergillus skin testing are more prone to moderate-severe or severe-uncontrolled asthma. Fungal sensitization is also associated with earlier onset of asthma and demonstrates a dose-dependent relationship of symptom severity and duration. Among viruses, rhinovirus has the greatest association with decreased lung function, severe asthma, and asthma-related hospital admissions. Distribution of microbial products and associated asthma symptoms depends on the geographical climate. Genetic variations among individuals also mitigate the effects of microbial products on asthma development and symptom severity. Summary Microbial products of bacteria, fungi, and viruses are associated with the development of asthma, more severe asthma symptoms, and worse outcomes. However, some early exposure studies have also demonstrated a protective effect. Bacterial and fungal products are related to decreased lung function and earlier onset of asthma. Viral products are related to asthma-associated hospital admissions; and the climate and patient genetics can also temper or intensify the relationships between microbial products, asthma development, and asthma symptom severity. Further research should focus on the effects of early microbe exposure and its interaction with human immune systems and asthma-related outcomes.

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Serum IgG Concentrations in Adult Patients Experiencing Virus-Induced Severe Asthma Exacerbations

Cited by 13 publications

References 39 publications

Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models

Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models

Vulnerability for Respiratory Infections in Asthma Patients: A Systematic Review

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

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