Serum IgM in primary biliary cirrhosis

Taal, B.G.; Schalm, Solko W.; Bruyn, A.M. de; Rooy, Felix W.M. de; Klein, F.

doi:10.1016/0009-8981(80)90353-8

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…One of our patients without this antibody had severe hypogammaglobulinemia especially involving IgG and IgM. The serum IgM concentration is elevated in almost all patients from 1.5-10 times the upper limit of normal [7,46,56,71]. In PBC, some of the serum IgM may be monomeric but some represent different IgM subgroups [71].…”

Section: Laboratory Findingsmentioning

confidence: 86%

See 1 more Smart Citation

The Natural History of Primary Biliary Cirrhosis

Kapelman¹,

Schaffner²

1981

Semin Liver Dis

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Section: Laboratory Findingsmentioning

confidence: 86%

“…The serum IgM concentration is elevated in almost all patients from 1.5-10 times the upper limit of normal [7,46,56,71]. In PBC, some of the serum IgM may be monomeric but some represent different IgM subgroups [71]. The serum IgM level does not correlate with the titer of mitochondrial antibody [46].…”

Section: Laboratory Findingsmentioning

confidence: 99%

The Natural History of Primary Biliary Cirrhosis

Kapelman¹,

Schaffner²

1981

Semin Liver Dis

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“…Such sex differences may be particularly important when interpreting immunoglobulin levels in diseases with unequal sex distribution. For instance, increased serum IgM levels are a characteristic diagnostic feature of primary biliary cirrhosis, which has a strong female predominance [4,6,7]. Also, significant increases in serum IgA and IgG were observed with age.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, high immunoglobulin levels (polyclonal gammopathy) are observed in liver diseases, chronic inflammatory diseases, haematological disorders, infections and malignancies [2]. Moreover, immunoglobulin levels aid in the diagnosis of some disorders, particularly liver diseases [3–7].…”

Section: Introductionmentioning

confidence: 99%

Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Gonzalez-Quintela¹,

Alende²,

Gudé³

et al. 2007

Clinical and Experimental Immunology

542

412

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SummaryThe present study investigated serum immunoglobulin (Ig) concentrations in relation to demographic factors, common habits (alcohol consumption and smoking) and metabolic abnormalities in an adult population-based survey including 460 individuals. Serum levels of interleukin (IL)-6, a marker of inflammation, were also determined. After adjusting for confounders, male sex was associated positively with IgA levels and negatively with IgM levels. Age was associated positively with IgA and IgG levels. Smoking was associated negatively with IgG levels. Heavy drinking was associated positively with IgA levels. Metabolic abnormalities (obesity and metabolic syndrome) were associated positively with IgA levels. Abdominal obesity and hypertriglyceridaemia were the components of metabolic syndrome associated most strongly with serum IgA. Heavy drinkers with metabolic syndrome showed particularly high serum IgA levels. Serum IL-6 levels were correlated positively with IgA and IgG concentrations. It is concluded that sex, age, alcohol consumption, smoking and common metabolic abnormalities should be taken into account when interpreting serum levels of IgA, IgG and IgM.

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“…3,4,28 Given that Tregs are well characterized for their ability to suppress the proliferation and activation of autoreactive CD4 ϩ and CD8 ϩ T cells, 16 we set out to determine whether a functional defect or deficiency of Tregs may contribute to disease progression in PBC. One factor that must be considered within the context of our findings is the potential effect of ursodeoxycholic acid-a naturally occurring bile acid taken by all PBC patients in this study-on the resulting data.…”

Section: Discussionmentioning

confidence: 99%