SERUM IL17 AND IL4R rs1805010 GENOTYPES: RELATIONSHIP WITH RHEUMATOID ARTHRITIS DISEASE ACTIVITY IN EGYPTIAN PATIENTS

Elnady, Basant; Ahmed, Inas A.; Alfayomi, Ghada; Mahgoub, Marwa Yahia

doi:10.21608/ejb.2017.9692

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained results of the serum IL-4R level indicate that there is a significant difference in women with osteoporosis compared to healthy women, and these results are consistent with previous study conducted (10). There is proof that polymorphisms in the functional candidate gene IL4R are linked to hand, knee, and hip osteoarthritis (19). As for the polymorphism of IL-4R, its effect on osteoporosis was not observed.…”

Section: Discussionsupporting

confidence: 88%

Evaluation of Serum Level and Interleukin-4 Receptor (rs1805010) Gene Polymorphism in a Sample of Osteoporosis Women

Hammadi,

Salih,

Rija

2023

Tikrit J. Pharm. Sci.

View full text Add to dashboard Cite

Background: Osteoporosis is characterized by subtle skeletal degeneration and bone loss, generally defined as a systemic metabolic disease. Interleukin-4 receptor (IL-4) R has been associated with osteoimmune, the relationship between the immune system and the skeleton (osteoimmune system) is studied in osteoimmunology. Objectives: In this study, we aimed to investigate the serum level and polymorphisms to genotype IL-4R )rs1805010 ( and their effect on osteoporosis in Iraqi women. Methods: ELISA was used to determine the serum level of the IL-4R and polymerase chain reaction (PCR) to genotype the IL4R gene in 90 Iraqi women (60 patients with osteoporosis and 30 control groups). Results: The main findings on the IL-4R polymorphism (rs1805010) indicated that there was no association for the prediction of osteoporosis in Iraqi women. Whereas, there was a significant increase in serum levels of interleukin-4 receptor in women with osteoporosis compared to healthy women, (P = 0.018). Conclusion: The study supposes that there is a link between the serum level of IL4R and how osteoporosis develops, but IL4R gene polymorphisms may not play a role in osteoporosis in women. Keywords: Osteoporosis, rs1805010, IL4R, Polymorphism.

show abstract

Section: Discussionsupporting

confidence: 88%