Serum immunoglobulin E levels in patients with primary biliary cirrhosis

Minuk, Gerald Y.; Boyd, Nigel D.; Matheson, David S.; Fritzler, Marvin J.; Green, B.J.

doi:10.1016/0091-6749(89)90134-6

Cited by 16 publications

(18 citation statements)

References 10 publications

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“…In alcoholics, serum IgE levels are not correlated with other immunoglobulins and, unlike serum IgA, serum IgE increases are unrelated to liver dysfunction (González-Quintela et al, 1995;Vidal et al, 1994). Furthermore, serum IgE levels are not increased in patients with nonalcoholic liver disease, such as patients with hepatitis C virusrelated chronic hepatitis and cirrhosis Vidal et al, 1994), and are even decreased in patients with primary biliary cirrhosis (Minuk et al, 1989). IgE synthesis needs B-cell stimulation by T-helper cell 2 (Th2)-type cytokines (Bacharier and Geha, 2000).…”

Section: Discussionmentioning

confidence: 98%

Influence of Alcohol Consumption on Serum Immunoglobulin E Levels in Atopic and Nonatopic Adults

Vidal

Armisén

Domínguez-Santalla

et al. 2002

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 98%

Influence of Alcohol Consumption on Serum Immunoglobulin E Levels in Atopic and Nonatopic Adults

Vidal

Armisén

Domínguez-Santalla

et al. 2002

Alcoholism Clin & Exp Res

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“…Serum IgE increase in alcoholics is unrelated to the severity of liver dysfunction [2, 34, 35, 36]. Moreover, low IgE levels have been observed in primary biliary cirrhosis [3]. As a whole, these data suggest that the cause of liver disease and not liver disease per se may underly IgE increase.…”

Section: Discussionmentioning

confidence: 73%

“…In this series, chronic hepatitis C was not associated with IgE increase. Serum IgE levels are commonly increased in patients with alcoholic cirrhosis, but not in cases of liver cirrhosis of a different origin [2, 3]. Serum IgE increase in alcoholics is unrelated to the severity of liver dysfunction [2, 34, 35, 36].…”

Section: Discussionmentioning

confidence: 99%

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Total Serum IgE Levels in Chronic Hepatitis C: Influence of Interferon Alpha Therapy

González‐Quintela¹,

Alende²,

Lojo³

et al. 2001

Int Arch Allergy Immunol

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Background: Liver disease has been considered a prominent cause of IgE elevation. No data on serum IgE levels in chronic hepatitis C have been reported. Interferon-α is a standard therapy for chronic hepatitis C. Cytokine use is a promising type of immunomodulation in the treatment of IgE-mediated diseases. The effects of interferon-α therapy on serum IgE have not been fully evaluated. The aim of the study was to evaluate both serum IgE levels in patients with chronic hepatitis C and the course of these levels after interferon-α therapy. Patients and Methods: Serum IgE was determined in 100 adult patients with chronic hepatitis C (24 atopics according to positive skin prick tests and 76 nonatopics) and in 75 healthy controls (25 atopics and 50 nonatopics). Serum IgE measurements were repeated at 1 and 3 months of therapy with recombinant interferon-α (3 × 106 units s.c. 3 times weekly) in 34 of these patients. Results: Serum IgE levels were similar in chronic hepatitis C patients and in controls when adjusted for atopic status. Among patients with chronic hepatitis C, serum IgE levels were unrelated to liver necroinflammatory activity. A modest but statistically significant increase of IgE values was observed after interferon-α therapy, particularly in patients with no virological response. Conclusions: Chronic hepatitis C is not a significant cause of increased total serum IgE values. Serum IgE increase in some patients with liver disease may be related to the cause of liver injury and not to liver disease per se. Interferon-α therapy in patients with chronic hepatitis C is followed by no modification or even a moderate increase of serum IgE values.

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“…However, this may be related to the cause of liver injury, and not to liver disease. As such, studies of Minuk, et al 7 reported low serum immunoglobulin E (IgE) levels in patients with primary biliary cirrhosis 7. In contrast, chronic hepatitis C did not cause increased total serum IgE values 6.…”

Section: Introductionmentioning

confidence: 98%

Immune Responses in Autoimmune Hepatitis: Effect of Prednisone and Azathioprine Treatment: Case Report

Bluth¹,

Kohlhoff²,

Norowitz³

et al. 2009

Int. J. Med. Sci.

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The role of the immune response in autoimmune hepatitis has not been studied before and after prednisone and azathioprine treatment. Distributions of blood lymphocytes (CD4+, CD8+, CD19+, CD23+, CD16/56+), levels of serum immunoglobulins (IgM, IgG, IgE, IgA) and cytokines (IFN-γ, IL-4, IL-12, TNFα ) were studied in a child (f/14 y/o) with autoimmune hepatitis before and after prednisone (20 mg/d) and azathioprine (50 mg/d) treatment (nephelometry, UniCAP Total IgE Fluoroenzymeimmunoassay, flow cytometry, cytokine ELISA). Patient was studied for 0-2.5 yrs; treatment was initiated 12 weeks post diagnosis. Numbers of CD4+ T cells increased (50%), while CD19+ and CD23+ cells decreased (>50%) post treatment; other lymphocyte subsets were unaffected by treatment. Serum IgG and IgE levels decreased (>50%) after treatment; serum IgM and IgA were within normal range and were not affected by treatment High levels of IFN-γ (5-23 pg/ml) were initially detected in serum, which decreased after treatment (<0.1 pg/ml). Furthermore, low levels of IL-4 (0.2 pg/mL) were detected before treatment, which were not detected after treatment (<0.1 pg/ml). In contrast, before treatment, IL-12 and TNFα were not detected in serum; however after treatment the levels of IL-12 and TNFα dramatically increased. Prednisone and azathioprine treatment decreased total serum IgG, IgE, IFN-γ and IL-4 levels, and blood CD19+ and CD23+ cells; however serum IL-12, TNFα and blood CD4+ T cells increased with treatment. Understanding immunomodulation in autoimmune hepatitis will provide better insight and mechanisms of this disease and may tailor more effective therapeutic intervention.

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Serum immunoglobulin E levels in patients with primary biliary cirrhosis

Cited by 16 publications

References 10 publications

Influence of Alcohol Consumption on Serum Immunoglobulin E Levels in Atopic and Nonatopic Adults

Influence of Alcohol Consumption on Serum Immunoglobulin E Levels in Atopic and Nonatopic Adults

Total Serum IgE Levels in Chronic Hepatitis C: Influence of Interferon Alpha Therapy

Immune Responses in Autoimmune Hepatitis: Effect of Prednisone and Azathioprine Treatment: Case Report

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