Serum Immunoglobulin Free Light Chains in Severe Forms of Atopic Dermatitis

Kayserová, Jana; Čapková, Štěpánka; Skalicka, A.; Vernerová, Eva; Poloučková, Andrea; Malinová, Věra; Bartůňková, Jiřina; Šedivá, Anna

doi:10.1111/j.1365-3083.2010.02376.x

Cited by 20 publications

(24 citation statements)

References 19 publications

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“…Therefore, another mechanism might be involved. Ig-fLC is a potential candidate, and plasma Ig-fLC concentrations were found to be increased in patients affected by cow's milk allergy and in infants suffering from AD as is the case in the current study (14,23). In a murine model for casein-induced food allergy, Ig-fLC was found to be pivotal for the acute allergic skin reaction and mast-cell degranulation.…”

Section: Discussionsupporting

confidence: 61%

See 1 more Smart Citation

Non‐digestible oligosaccharides reduce immunoglobulin free light‐chain concentrations in infants at risk for allergy

Schouten

Esch

Kormelink

et al. 2011

Pediatric Allergy Immunology

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Prebiotic oligosaccharides influence the intestinal microbiota and can positively modulate the infant's immune system. It was demonstrated that a special prebiotic mixture (Immunofortis(®)) of short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) can reduce the cumulative incidence of atopic dermatitis (AD) in infants at risk for allergy as determined using the AD symptom score (SCORAD). Additionally, it was shown very recently that immunoglobulin free light-chain (Ig-fLC) might be involved in the pathophysiology of allergic disease. Increased Ig-fLC concentrations were found in patients suffering from AD, cow's milk allergy, allergic rhinitis, or asthma. In this study, the effect of supplementation of scGOS/lcFOS on the Ig-fLC plasma concentrations in infants at risk for allergy was assessed. The plasma kappa and lambda Ig-fLC concentrations were measured in a double-blind, placebo-controlled, randomized trial, in which infants at risk for developing allergic disease received a hypoallergenic whey formula containing 8 g/l of the scGOS/lcFOS mixture (n = 34) or maltodextrin as a placebo (n=40) for 6 months. After intervention, plasma samples were collected, and total plasma concentrations of lambda and kappa Ig-fLC were analyzed using ELISA. Total kappa and lambda Ig-fLC plasma concentrations were higher in infants suffering from AD when compared to infants without any sign of AD. In infants receiving the prebiotic mixture, the Ig-fLC levels were significantly lower compared to the placebo-fed infants (p<0.001). Interestingly, lambda Ig-fLC concentrations were positively correlated with total IgE (p<0.05). These data demonstrate for the first time that the specific scGOS/lcFOS mixture lowered kappa and lambda Ig-fLC plasma concentrations in infants at high risk for allergies when compared to infants receiving placebo formula. Because Ig-fLC concentrations were increased in infants suffering from AD, this may have contributed, at least in part, to the reduced incidence in AD as described previously. This suggests a possible role for Ig-fLC in the pathophysiology of AD in infants at risk for allergy development.

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Section: Discussionsupporting

confidence: 61%

“…Also Kayserova et al. (23) showed that both kappa and lambda Ig‐fLC were enhanced in serum from AD patients when compared to healthy age‐matched controls (n = 102). In the current study, the lambda Ig‐fLC concentrations correlated positively with total IgE.…”

Section: Discussionmentioning

confidence: 96%

Non‐digestible oligosaccharides reduce immunoglobulin free light‐chain concentrations in infants at risk for allergy

Schouten

Esch

Kormelink

et al. 2011

Pediatric Allergy Immunology

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“…We published earlier that serum levels of IgLC of patients with nonatopic asthma are increased (19). Also, in other chronic inflammatory conditions, such as rhinitis, dermatitis, and rheumatoid arthritis, increases in serum or local IgLC have been demonstrated (32)(33)(34) To our knowledge, we are the first to describe that IgLC may be associated with mast cell activation in the development of IBD. Our data in an experimental model for IBD support the presence of increased IgLC levels in serum and tissue from patients with IBD, whereas treatment with immunosuppressive drugs decreased serum IgLC.…”

Section: Discussionmentioning

confidence: 74%

Ig-Free Light Chains Play a Crucial Role in Murine Mast Cell-Dependent Colitis and Are Associated with Human Inflammatory Bowel Diseases

Rijnierse

Redegeld

Blokhuis

et al. 2010

The Journal of Immunology

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Traditionally, mast cells were regarded as key cells orchestrating type I hypersensitivity responses. However, it is now recognized that mast cells are widely involved in nonallergic (non-IgE) chronic diseases. Also, in inflammatory bowel disease (IBD), a disease not associated with increased IgE concentrations, clear signs of activation of mast cells have been found. In this study, we investigated if Ig-free L chain-induced hypersensitivity-like responses through activation of mast cells could contribute to the pathophysiology of IBD. As a mast cell-dependent model for IBD, mice were skin-sensitized with dinitrofluorobenzene followed by intrarectal application of the hapten. In this murine IBD model, F991 prevented mast cell activation and also abrogated the development of diarrhea, cellular infiltration, and colonic lymphoid follicle hyperplasia. Furthermore, passive immunization with Ag-specific Ig-free L chains (IgLCs) and subsequent rectal hapten challenge elicited local mast cell activation and increased vascular permeability in the colon of mice. Clinical support is provided by the observation that serum concentrations of IgLCs of patients suffering from Crohn’s disease are greatly increased. Moreover, increased presence of IgLCs was evident in tissue specimens from colon and ileum tissue of patients with IBD. Our data suggest that IgLCs may play a role in the pathogenesis of IBD, which provides novel therapeutic means to prevent or ameliorate the adverse gastrointestinal manifestations of IBD.

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“…возбу-дителям. Ведущая роль в развитии заболевания отво-дится иммунным нарушениям, наиболее значимыми из которых являются дисбаланс Th-1-и Th-2-клеток, повышенная дегрануляция тучных клеток и изменен-ная антигенпрезентирующая активность клеток Лан-герганса [19,28,34].…”

Section: атопический дерматит вульвы и/и ли проме жнос тиunclassified

Possibilities of topical treatment of inflammatory diseases of vulva and vagina in girls

et al. 2017

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Vulvitis and vaginitis in girls are the most frequent reason for contacting a pediatric gynecologist. The article considers options for local treatment with various forms of inflammation of the vulva and vagina. In recent years, there has been an increase in this pathology. The maximum number of appeals is observed at 1 year of age and at the age of 3-7 years. The formation of the inflammatory process in the vagina is caused by the state of the endocrine and immune systems, as well as a number of anatomical and physiological features of the structure of the external sexual organs. An important role in the development of vulvovaginitis and vulvitis is played by extragenital pathology. The development of the secondary inflammatory process in the vagina provokes such diseases as urinary tract infection, dysbacteriosis, atopic dermatitis, noopharyngeal diseases, frequent colds, transient immunodeficiency states, childhood infections. The clinical manifestations of vulva-guinitis and vulvitis are similar and depend on the severity of the process, the type of exciter. In acute nonspecific vulvovaginitis, a vivid clinical picture is typical. This discharge from the genital tract, hyperemia and swelling of the vulva, discomfort, burning with urination. The diagnosis of the disease is based on the details of complaints, clinical picture, laboratory and instrumental diagnostic methods. In the treatment of non-specific vulvovaginitis, girls rarely resort to the use of systemic antibacterial drugs. Preference is given to topical preparations. The advantage of local treatment is a minimal risk of adverse reactions, simplicity and ease of use, in the absence of contraindications (except for individual intolerance of the drug), as well as in the possibility of use in extragenital pathology.

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Serum Immunoglobulin Free Light Chains in Severe Forms of Atopic Dermatitis

Cited by 20 publications

References 19 publications

Non‐digestible oligosaccharides reduce immunoglobulin free light‐chain concentrations in infants at risk for allergy

Non‐digestible oligosaccharides reduce immunoglobulin free light‐chain concentrations in infants at risk for allergy

Ig-Free Light Chains Play a Crucial Role in Murine Mast Cell-Dependent Colitis and Are Associated with Human Inflammatory Bowel Diseases

Possibilities of topical treatment of inflammatory diseases of vulva and vagina in girls

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