Serum immunoglobulin levels A, G, M, D and TNM classification in breast cancer

Munzarová, Marta; Trnka, A; Malír, A

doi:10.1038/bjc.1977.73

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…High blood Igs and circulating immune complex values in patients with cancer have been repeatedly reported and suggested as tumor markers with varying regulation patterns in numerous cancers . However, there has been no evidence suggesting Ig chains as biomarkers of cancer.…”

Section: Discussionmentioning

confidence: 99%

Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients

et al. 2013

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In the present study, we screened proteomic and cytokine biomarkers between patients with adenomatous polyps and colorectal cancer (CRC) in order to improve our understanding of the molecular mechanisms behind turmorigenesis and tumor progression in CRC. To this end, we performed comparative proteomic analysis of plasma proteins using a combination of 2DE and MS as well as profiled differentially regulated cytokines and chemokines by multiplex bead analysis. Proteomic analysis identified 11 upregulated and 13 downregulated plasma proteins showing significantly different regulation patterns with diagnostic potential for predicting progression from adenoma to carcinoma. Some of these proteins have not previously been implicated in CRC, including upregulated leucine-rich α-2-glycoprotein, hemoglobin subunit β, Ig α-2 chain C region, and complement factor B as well as downregulated afamin, zinc-α-2-glycoprotein, vitronectin, and α-1-antichymotrypsin. In addition, plasma levels of three cytokines/chemokines, including interleukin-8, interferon gamma-induced protein 10, and tumor necrosis factor α, were remarkably elevated in patients with CRC compared to those with adenomatous polyps. Although further clinical validation is required, these proteins and cytokines can be established as novel biomarkers for CRC and/or its progression from colon adenoma.

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Section: Discussionmentioning

confidence: 99%

Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients

et al. 2013

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“…Thus, using Density Functional Theory (DFT) for the calculation of the molecular structure (geometry), electronic structure, and magnetic resonance parameters of EPR-active centers is often an excellent compromise of accuracy and computational demands. 28,[30][31][32] The validation and identification of the "real" geometric and electronic structure of paramagnetic centers in this case has to be done by careful comparison of the experimental and theoretically calculated parameters.…”

Section: Introductionmentioning

confidence: 99%

One Electron Multiple Proton Transfer in Model Organic Donor–Acceptor Systems: Implications for High-Frequency EPR

et al. 2020

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EPR spectroscopy is an important spectroscopic method for identification and characterization of radical species involved in many biological reactions. The tyrosyl radical is one of the most studied amino acid radical intermediates in biology. Often in conjunction with histidine residues, it is involved in many fundamental biological electron and proton transfer processes, such as in the water oxidation in photosystem II. As biological processes are typically extremely complicated and hard to control, molecular bio-mimetic model complexes are often used to clarify the mechanisms of the biological reactions. Here we present theoretical calculations to investigate the sensitivity of magnetic resonance parameters to proton-coupled electron transfer events, as well as conformational substates of the molecular constructs which mimic the tyrosine-histidine (Tyr-His) pairs found in a large variety of proteins. Upon oxidation of the phenol, the Tyr analogue, these complexes can perform not only one-electron one-proton transfer (EPT), but also one-electron two-proton transfers (E2PT). It is shown that in aprotic environment the g X -components of the electronic g-tensor are extremely sensitive to the first proton transfer from the phenoxyl oxygen to the imidazole nitrogen (EPT product), leading to a significant increase of the g X -value of up to 0.003, but are not sensitive to the second proton transfer (E2PT product). In the latter case the change of the g X -value is much smaller (ca. 0.0001), which is too small to be distinguished even by high frequency EPR. The 14 N hyperfine values are also too similar to allow differentiation between the different protonation states in EPT and E2PT. The magnetic resonance parameters were also calculated as a function of the rotation angles around single bonds. It was demonstrated that rotation of the phenoxyl group results in large positive changes (>0.001) in the g X -values. Analysis of the data reveals that the main source of these changes is related to the strength of the H-bond between phenoxyl oxygen and the proton(s) on N 1 and N 2 positions of the imidazole.

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Serum protein changes in women with earLY BREAST CANCER

Thompson

Haddow

Smith

et al. 1981

Cancer

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Lowered serum concentrations of albumin, IgG, IgM, and transferrin have been identified preopera-tively in a population of otherwise healthy white women over age 40 with early stage breast cancer. Definition of low values for each of the four serum proteins has been arrived at via comparison with age-matched controls, consisting of disease-free women and women with benign breast lesions. Thus defined, low values for the individual serum proteins have been found to occur in malignantlcontrol study subjects at the following frequencies: albumin 68%/4.7% (P < 0.OOOl); IgG 56%/21% (P < 0.02); IgM SWi/19% (P < 0.001), and transferrin 50%/4.7% (P < 0.OOOl). Among the relevant historical and pathologic data evaluated in addition to the presence or absence of malignancy, only age has been found significant in influencing serum protein concentrations, and this has been taken into account in analyzing results. Forty-four percent of study sujects subsequently found to have breast cancer have low concentrations of at least three of the four discriminant proteins simqltaneously in the pre-operative sample. None of the contrsls have these findings. Twenty-nine percent of women with a malignant breqt lesion and WO of controls have simultaneously low concentrations of two of the four discriminant proteins. Using these measurements of serum proteins it thus becomes possible to assign risk of malignancy when a woman is found to have a breast mass. Cancer 48:793-798, 1981. NE OF THE SIGNIFICANT recent advances in can-0 cer diagnosis has been the discovery of several soluble tumor-associated proteins which can be assayed in serum. Carcinoembryonic antigen, the first among these to find clinical application, is now recognized as lacking specificity for diagnosing gastrointes-tinal tumors.' Alpha-fetoprotein demonstrates better specificity for hepatomas and germ cell tumors, a relatively uncommon group of malignancies in the United States. Human chorionic gonadotropin falls into a similar category.2 Breast cancer is one of the tumors for which no specific circulating protein has yet been found.3 As an alternate path of study, a number of investigators have measured normally occurring, nonspecific serum proteins in breast cancer patients. To date, these studies have produced inconclusive ~esults,4-~O possibly because clinical parameters have been insufficiently documented and methodology has been relatively imprecise. The present report continues along this line of investigation, utilizing more precise methodology both for the laboratory and for clinical data

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Serum immunoglobulin levels A, G, M, D and TNM classification in breast cancer

Abstract: THE few studies on the levels of the major immunoglobulin classes (IgA,

Cited by 5 publications

References 9 publications

Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients

Proteomic and cytokine plasma biomarkers for predicting progression from colorectal adenoma to carcinoma in human patients

One Electron Multiple Proton Transfer in Model Organic Donor–Acceptor Systems: Implications for High-Frequency EPR

Serum protein changes in women with earLY BREAST CANCER

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