Serum immunoglobulins in epilepsy

Slavin, Brenda; Fenton, G.M.; Laundy, M.; Reynolds, E. H.

doi:10.1016/0022-510x(74)90153-1

Cited by 41 publications

(24 citation statements)

References 9 publications

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“…After the approval of the use of CBZ for the treatment of convulsive seizures in 1974, several studies have evaluated the repercussions of this medication on the immune system [3][4][5][6][7][8][9][10][11][12][13][14][15][16] . The alterations in cellular immunity have been extensively studied 3 , but the serum concentration and function of immunoglobulins still receives special attention in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, when the relationship of CBZ to immunoglobulin levels is evaluated, data from the literature are often contradictory. The reduction in serum IgA levels is the change most frequently reported after the use of anticonvulsants, with total and partial immunodeficiency having been reported 3,8,[9][10][11] . Symptoms similar to those of patients with primary IgA deficiency may arise in these patients, such as recurrent infections, greater prevalence of atopy, autoimmune diseases such as systemic lupus erythematosus, and lymphoproliferative diseases such as lymphomas 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Most of the studies on the immunologic behavior of CBZ users reported no variations in IgG levels, but rather a decrease in serum IgA and IgM levels 3,[8][9][10][11] , with few reports of changes in IgG concentrations related to CBZ use [4][5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

“…Among the changes described are IgA and IgM deficiency, and reduced DNA and RNA synthesis in circulating leukocytes and in cultured lymphocytes stimulated with phytohemagglutinin (PHA) 3 . Decreased serum IgG levels have been reported in a few studies and in isolated clinical cases [4][5][6][7] , with the reduction in IgA being the change most commonly noted 3,[8][9][10][11] .…”

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confidence: 99%

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Secondary hypogammaglobilinemia after use of carbamazepine: case report and review

et al. 2001

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Immunologic disorders related to anticonvulsant therapy have been described in the last three decades, including cellular and humoral alterations that result in recurrent infections; however, the physiopathologic mechanisms are not completely understood.This report describes a patient with complex partial epilepsy and hypogammaglobulinemia while in treatment with carbamazepine, with significant improvement in clinical signs and laboratory tests after substitution to sodium valproate.The authors stress the importance of clinical and laboratory evaluation of patients in continuous anticonvulsant therapy, including immunoglobulins levels and peripheral blood evaluations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Secondary hypogammaglobilinemia after use of carbamazepine: case report and review

et al. 2001

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“…the concentration of immuno globulin A (IgA) is reduced in serum and saliva (3,9,15,18). A reduced concentration of immunoglobulin G (IgG) in serum has been found by some (1,2,4,13,16) but not by others (5,9,17).…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin G in Serum and Cerebrospinal Fluid from Epileptic Patients Treated with Phenytoin

Fossan¹,

Aarli²

1979

Eur Neurol

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Concentrations of IgG and titres of IgG antibodies to rabbit erythrocytes were studied in serum and cerebrospinal fluid (CSF) from 21 phenytoin-treated patients; 11 of these had reduced serum IgA. The CSF IgG concentration was not reduced in any patient. A reduction of CSF IgG has been found earlier in phenytoin-treated patients, when other antisera to IgG were used for the determination of IgG concentration. The present findings therefore indicate that an alteration of the composition or quality of the CSF IgG is present in phenytoin-treated patients. 1 patient had a phenytoin-induced low serum concentration of IgG and IgA. In this patient the ratios CSF:serum were normal both for IgG concentration and for IgG antibodies to rabbit erythrocytes.

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Drug-Induced IgA Deficiency in Epileptic Patients

Aarli¹

1976

Archives of Neurology

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Serum concentrations of IgA, IgG, and IgM were determined by immunodiffusion technique in 184 epileptic patients and 95 healthy individuals. Twenty-one percent of adult and 42% of children patients receiving anticonvulsants had serum IgA levels below 0.6 mg/ml (the lowest value detected in normal sera). Serum concentrations in non-drug-taking epileptic patients were normal. Deviations in IgG/IgM concentrations were smaller and less consistent. Serum IgA level was determined at intervals before and during phenytoin treatments. A fall in the IgA level occurred in several patients. In two patients, IgA deficiency developed within two to three months of treatment. Low IgA-responders were more frequent among men and children. The IgA anomaly was not specific for any type of epilepsy.

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Serum immunoglobulins in epilepsy

Cited by 41 publications

References 9 publications

Secondary hypogammaglobilinemia after use of carbamazepine: case report and review

Secondary hypogammaglobilinemia after use of carbamazepine: case report and review

Immunoglobulin G in Serum and Cerebrospinal Fluid from Epileptic Patients Treated with Phenytoin

Drug-Induced IgA Deficiency in Epileptic Patients

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