Serum immunoreactive erythropoietin in hyper‐ and hypothyroidism: Clinical observations related to cell culture studies

Bm, Brenner; Fandrey, Joachim; Jelkmann, Wolfgang

doi:10.1111/j.1600-0609.1994.tb00171.x

Cited by 17 publications

(4 citation statements)

References 19 publications

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“…This effect might be a result of the modulatory action of THs on the production of EPO. It has been demonstrated that a high concentration of THs increases the production of this hormone (10,11,25). However, in our model of in vitro cultures with an established amount of EPO given at the moment of growth induction, we observed the increased growth potential only in the samples collected from the hyperthyroid patients.…”

Section: Discussioncontrasting

confidence: 43%

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies

Kawa¹,

Grymuła²,

Paczkowska

et al. 2010

European Journal of Endocrinology

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Objective: Abnormalities in haematological parameters have been noted in patients with thyroid diseases. Nevertheless, the exact mechanism of thyroid hormones' (THs) action on human haematopoiesis is still not entirely clear. Design: The influence of THs through TH receptors (TRa-1 and TRb-1) on haematopoiesis in patients with hypo-and hyperthyroidism was analysed. Methods: TR gene expression at the mRNA and protein levels in human CD34C -enriched haematopoietic progenitor cells (HPCs) obtained from the peripheral blood of patients with thyroid disorders and healthy volunteers was analysed. The cell populations were also investigated for clonogenic growth of granulocyte macrophage-colony forming units and erythrocyte-burst forming units (BFU-E). The level of apoptosis was determined by annexin V/propidium iodide staining and quantitative RT-PCR. Results: The studies revealed that hypo-and hyperthyroidism modify TR gene expression in HPCs in vivo. TH deficiency resulted in a decrease in total blood counts and clonogenic potential of BFU-E. In contrast, hyperthyroid patients presented increased clonogenic growth and BFU-E number and significantly higher expressions of cell cycle-regulating genes such as those for PCNA and cyclin D1. Finally, an increase in the frequency of apoptotic CD34C -enriched HPCs in hypo-and hyperthyroidism with a modulation of apoptosis-related genes was detected. Conclusions: The following conclusions were derived: i) TR expression in human haematopoietic cells depends on TH status, ii) both hypo-and hyperthyroidism significantly influence clonogenicity and induce apoptosis in CD34 C -enriched HPCs and iii) the molecular mechanism by which THs influence haematopoiesis might provide a basis for designing novel therapeutic interventions in thyroid diseases.

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Section: Discussioncontrasting

confidence: 43%

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies

Kawa¹,

Grymuła²,

Paczkowska

et al. 2010

European Journal of Endocrinology

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“…Brenner et al measured serum EPO in 29 patients with hyperthyroidism and 10 patients with hypothyroidism and reported significantly higher level of EPO in the hyperthyroid group (8). Another study showed that erythropoiesis was increased in 21 patients with hyperthyroidism, and this was accompanied with an elevation in serum EPO levels (9).…”

Section: Discussionmentioning

confidence: 96%

Erythrocytosis associated with hyperthyroidism: a rare case report and clinical study of possible mechanism

Liu

et al. 2015

Endocrine Research

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“…ypothyroidism is a systemic disease affecting all organs [1]. Research has shown that thyroid hormone imbalance in hypothyroid patients is associated with anemia in these patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron on Thyroid Function in Women With Hypothyroidism: A Double-blind Clinical Trial Study

Shiravand

Talaei

2019

J. Arak Univ. Med. Sci.

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Background and Aim Thyroid diseases are among the most common endocrine disorders. Animal and human experiences indicate that iron deficiency disrupts thyroid metabolism. On the other hand, iron therapy can improve thyroid function and even decrease the dose of levothyroxine. Methods and Materials In this randomized clinical trial, we selected 94 women with hypothyroidism by simple random sampling method and divided them into two equal groups by simple block sampling. At the beginning of the study, we measured and recorded T 4 , TSH, T 3 , and iron profiles (Serum iron, total iron-binding capacity, ferritin, Hemoglobin) in all patients. Then, the patients in the intervention group were treated with levothyroxine plus 100 mg oral iron daily for 8 weeks, and the patients in the control group were treated with levothyroxine only. After two months, we measured their T 4 , TSH, T 3 levels and iron profiles in both groups again. Ethical Considerations The Research Ethics Committee of Arak University of Medical Sciences approved this study (Research Ethics Code: 1396154). Also, the study has been registered at the Iranian Registry of Clinical Trials (Code: IRCT 20151114025031). Results After 2 months, the TSH Mean±SD serum levels were found as 2.2±1.0 mIU/L and 2.9±1.1 mIU/L for the intervention and control group, respectively (P=0.04). Also, the serum Mean±SD level of T 4 and T 3 were found as 9.3±1.48 mcg/dL vs. 8.2±0.9 mcg/dL (P=0.01), and 1.6±0.3 ng/mL vs. 1.1±0.3 ng/mL (P=0.01), for two different groups, respectively. Conclusion Concurrent administration of iron supplementation with the usual dose of levothyroxine in patients with hypothyroidism decreases THS level and improves laboratory parameters and response to treatment.

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Serum immunoreactive erythropoietin in hyper‐ and hypothyroidism: Clinical observations related to cell culture studies

Cited by 17 publications

References 19 publications

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies

Erythrocytosis associated with hyperthyroidism: a rare case report and clinical study of possible mechanism

Effect of Iron on Thyroid Function in Women With Hypothyroidism: A Double-blind Clinical Trial Study

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