Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermia

Goulis, Dimitrios G.; Tsametis, Christos; Iliadou, Paschalia K; Polychronou, Paris; Kantartzi, Persefoni-Dimitra; Tarlatzis, Basil C.; Bontis, Ioannis; Papadimas, Ioannis

doi:10.1016/j.fertnstert.2008.01.010

Cited by 57 publications

(35 citation statements)

References 40 publications

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“…No significantly better sperm retrieval predictions were obtained with combination of the study variables ( Figure 3). In conclusion, this study 31 did not provide evidence that serum inhibin B and AMH concentrations are superior to FSH or testicular volume as predictors of the presence of sperm in testicular FNA in men with azoospermia.…”

Section: The Role Of Inhibin B and Amh In Prediction Of Sperm Retrievalcontrasting

confidence: 83%

“…Therefore, we designed a cross-sectional study aiming to examine inhibin B and AMH as predictors of the recovery of sperm in testicular FNA performed in men with azoospermia and compare their predictive value with that of FSH and testicular volume. 31 We prospectively recruited and studied 51 subfertile men with azoospermia. We found a significant correlation between inhibin B and cytological diagnosis, with inhibin B concentrations levels following a "progressive" pattern with declining concentrations as we moved from less severe (e.g.…”

Section: The Role Of Inhibin B and Amh In Prediction Of Sperm Retrievalmentioning

confidence: 99%

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The Sertoli cell: Novel clinical potentiality

Iliadou¹,

Tsametis²,

Kaprara³

et al. 2015

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Section: The Role Of Inhibin B and Amh In Prediction Of Sperm Retrievalcontrasting

confidence: 83%

Section: The Role Of Inhibin B and Amh In Prediction Of Sperm Retrievalmentioning

confidence: 99%

The Sertoli cell: Novel clinical potentiality

Iliadou¹,

Tsametis²,

Kaprara³

et al. 2015

Self Cite

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“…One study has shown that lower AMH levels are seen in men with testicular dysfunction, whereas another study found no such relationship (26,27). The true relationship between serum AMH and male fertility remains to be established, but currently AMH seems inferior to FSH as a marker of sperm production (28). Our results contrast with earlier findings of marginally increased FSH levels in treated men (8).…”

Section: Discussioncontrasting

confidence: 97%

Fatherhood in Tall Men Treated with High-Dose Sex Steroids during Adolescence

Hendriks¹,

Boellaard²,

Casteren³

et al. 2010

The Journal of Clinical Endocrinology & Metabolism

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“…However, the absence of sperm cells in a single semen sample is not conclusive. Inhibin B is another marker of reduced spermatogenesis, but it is questionable whether the marker is clinically more valuable than FSH [22].…”

Section: Discussionmentioning

confidence: 99%

Gonadal function and parenthood 20 years after treatment for childhood lymphoma: A cross‐sectional study

Hamre

Kiserud

Ruud

et al. 2011

Pediatric Blood & Cancer

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BackgroundGonadal function decades after treatment for childhood lymphoma (CL) is not well described. This cross‐sectional study had two aims: (1) describe long‐term gonadal function and fertility in childhood lymphoma survivors (CLSs), and (2) explore anti‐Mullerian hormone (AMH) as a measure of ovarian function in CLSs.ProcedureSeventy‐four male and 62 female CLSs participated in a survey consisting of a questionnaire, clinical examination, and blood/semen analysis. Prior treatment was categorized according to gonadotoxicity. Hypogonadism was determined by levels of gonadal hormones based on luteinizing hormone, follicle‐stimulating hormone, testosterone (males), AMH (females <40 years), and menstrual status. Fertility was explored according to pregnancies achieved, semen analysis, and AMH.ResultsHypogonadism was observed in 7 of 66 males (11%). Seven of 64 males (11%) were categorized as infertile. Nine of 45 females <40 years (20%) were at risk to develop premature ovarian failure (POF). Twenty of 45 females (44%) showed low‐AMH levels indicating decreased fertility. Four “critically low” females reported pregnancies within the preceding 2 years. Sixty‐four percent of the males and 93% of the females attempting parenthood had been successful (P = 0.01). Hypogonadism and low‐AMH were related to treatment burden.ConclusionTwenty years after treatment of CL, female CLSs' attempts of pregnancy initiation are mostly successful, while males seem at higher risk of infertility. Hypogonadism is a problem in 10% of the male CLSs. Based on AMH levels, POF is a risk in 20% of the female CLSs. The clinical significance of AMH reflecting true probability of fertility needs further research in cancer survivors. Pediatr Blood Cancer 2012;59:271–277. © 2011 Wiley Periodicals, Inc.

show abstract

Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermia

Cited by 57 publications

References 40 publications

The Sertoli cell: Novel clinical potentiality

The Sertoli cell: Novel clinical potentiality

Fatherhood in Tall Men Treated with High-Dose Sex Steroids during Adolescence

Gonadal function and parenthood 20 years after treatment for childhood lymphoma: A cross‐sectional study

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