Serum inhibin B may be a reliable marker of the presence of testicular spermatozoa in patients with nonobstructive azoospermia

Brugo-Olmedo, Santiago; Vincentiis, Sabrina De; Calamera, J.C.; Urrutia, Fernando; Nodar, F.; Acosta, Anı́bal A.

doi:10.1016/s0015-0282(01)02866-7

Cited by 77 publications

(48 citation statements)

References 21 publications

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20] A number of authors report on the use of inhibin B serum levels to determine testicular function. 8,[11][12][13][14]16,17,21 While inhibin B levels are generally lower in those men with more severe testicular dysfunction and is undetectable in those with a Sertoli cell only pattern on testis biopsy, inhibin B levels in men with maturation arrest or hyopospermatogenesis patterns on testis biopsies may be identical to those found in men with full sper- The workup of azoospermic males matogenesis. At present, serum inhibin B levels do not provide significant clinical benefit: with high FSH the inhibin B levels are generally low (both indicating testicular failure), while with normal FSH the inhibin B levels are generally normal (both indicating either obstructive or non-obstructive azoospermia) (Level of evidence 3, Grade C recommendation).…”

Section: Differentiating the Causes Of Normal Volume Azoospermiamentioning

confidence: 99%

CUA Guideline: The workup of azoospermic males

Jarvi¹,

Lo²,

Fischer³

et al. 2013

CUAJ

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Section: Differentiating the Causes Of Normal Volume Azoospermiamentioning

confidence: 99%

CUA Guideline: The workup of azoospermic males

Jarvi¹,

Lo²,

Fischer³

et al. 2013

CUAJ

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“…Byrd et al (1998) consequently suggested that inhibin B could potentially be used as a biomarker in the diagnosis of cryptorchidism and precocious puberty. Studies by Brugo-Olmedo et al (2001) suggested that serum inhibin B levels might also be a reliable marker of the presence of testicular spermatozoa in patients with nonobstructive azoospermia. If this is confirmed, it could be used as another biomonitoring approach to assessing pubertal onset in boys.…”

Section: Molecular and Cellular Biomarkers Of Pubertymentioning

confidence: 99%

Biomarkers for assessing reproductive development and health: Part 1--Pubertal development.

Rockett

Lynch

Buck

2004

Environ Health Perspect

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The proposed National Children's Study has helped raise awareness of the issues related to children's health and the importance of monitoring the growth and development of children from preconception through adulthood. Many genetic predispositions can adversely impact the normal development process, and various environmental exposures have been linked to adverse reproductive health in rodent models and a small number of accidental human exposures. To monitor reproductive health and identify adverse effects at the earliest possible juncture, investigators must develop a network of biomarkers covering all stages and aspects of reproductive development and function. Biomarkers are biological indicators that can be measured repeatedly and are informative on one or more aspects of biological development or function. They can range from the anatomical level down to the molecular level and may provide information on the nature of an exposure, the effect of an exposure, or the susceptibility of individuals or populations to the toxic effects of an exposure. In theory, biomarkers can be used to monitor a wide variety of conditions and responses ranging from abnormal development to early indicators of late-onset disease. The main stumbling block with this theory has been finding appropriate biomarkers for particular conditions and exposures. Such biomarkers must be easily accessible, robust, and sensitive. Ideally, they will be expressed across a large section of the population, and can be monitored quickly, easily, conveniently, and with minimal cost. In this review, we discuss some of the current and emerging biomarkers of human pubertal development.

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“…However, the diagnostic accuracy of FSH is limited by the fact that some conditions do not lead to changes in FSH secretion (9). FSH and inhibin B are complementary tools in gonadal male conditions and andrological diagnostics (10,11,12,13,14,15). In particular, FSH and inhibin B together are more sensitive than either alone in predicting the histological status of the testis and the presence of sperm in bioptic tissue (11,15).…”

Section: Introductionmentioning

confidence: 99%

The serum inhibin B concentration and reference ranges in normozoospermia

Barbotin

Ballot

Sigala

et al. 2015

European Journal of Endocrinology

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Objective: Although an inhibin B assay may be useful in the assessment of testicular function in a number of genital conditions, reliable reference ranges are still lacking. The present study sought to establish the reference range for serum inhibin B by applying the updated Gen II assay. Design: This prospective study included 818 men referred for semen analysis: 377 were normozoospermic (reference group) and 441 presented at least one abnormal semen parameter (case group). Methods: Semen parameters were interpreted according to the 2010 World Health Organization manual and David's modified classification for normal morphology. The inhibin B concentration was determined with the current ELISA. Results: In the reference group, the 2.5th percentile for inhibin B was 92 pg/ml and the 97.5th percentile for FSH was 7.8 IU/l. In the overall population, an inhibin B level !92 pg/ml was associated with increased odds ratio (OR; 95% CI) for oligozoospermia (16.93 (9.82-29.18), P!0.0001), asthenozoospermia (4.87 (2.88-8.10), P!0.0001), and teratozoospermia (2.20 (1.31-3.68), PZ0.0026). The combination of a FSH O7.8 IU/l and an inhibin B !92 pg/ml was associated with greater OR for oligozoospermia (98.74 (23.99-406.35), P!0.0001) than for each hormone considered separately. Conclusions: A new reference range for serum inhibin B was established by the use of updated immunoassay. The correlations between hormone levels and semen parameters highlighted the importance of establishing these values with respect to the spermogram. When combined with FSH assay, the inhibin B range may be of value in the evaluation of spermatogenesis in a number of male genital conditions.

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Serum inhibin B may be a reliable marker of the presence of testicular spermatozoa in patients with nonobstructive azoospermia

Cited by 77 publications

References 21 publications

CUA Guideline: The workup of azoospermic males

CUA Guideline: The workup of azoospermic males

Biomarkers for assessing reproductive development and health: Part 1--Pubertal development.

The serum inhibin B concentration and reference ranges in normozoospermia

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