Serum Inhibitors of Elastase, Trypsin, and Plasmin in Chronic Rheumatic Diseases

BIOCHEMICAL AND CLINICAL STUDIES NO. 1: A Simplified Method of Estimating Total Serum Trypsin Inhibitors and their Relationship to known Serum Anti‐trypsins

“…It is 75 years since Camus and Gley 1 reported the presence of a trypsin inhibitor in serum. Since this time numerous authors have described conditions in which the trypsin inhibitor concentration of serum is abnormally low, resulting in respiratory disease in later life, 2‐11 or elevated as in traumatic injury, 12 , 13 acute and chronic inflammation, 13 , 14 myocardial infarction, 13 , 15 , 20 acute bacterial infections, 16 , 17 , 20 rheumatic disease, 18 cystic fibrosis, 14 pregnancy 13 , 19 and many forms of neoplastic disease. 16 , 17 , 20 …”