2002
DOI: 10.1038/sj.bjc.6600526
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Serum insulin level, disease stage, prostate specific antigen (PSA) and Gleason score in prostate cancer

Abstract: In the present study, we assessed the relationship of serum insulin levels and three surrogate markers of recurrence, T stage, PSA, and Gleason score, in men with localized prostate cancer. Participants in our study were found through urology and radiation oncology clinics, and all eligible patients were asked to take part. All patients were asymptomatic and had been initially diagnosed on the basis of rising PSA or abnormal physical examination. Histological confirmation of diagnosis was obtained for all subj… Show more

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Cited by 45 publications
(27 citation statements)
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“…Significant positive correlations were found only between fasting insulin indices and cancer spread in the patients with highly and moderately differentiated endometrial adenocarcinomas which, as mentioned earlier, are mainly type I (Table 3). The association noted is most probably not an accidental coincidence due to the following reasons: 1) quite solid statistical significance was reached regarding the correlation analysis results; 2) the association of hyperinsulinemia with cancer progression is biologically explainable (there are several mechanisms capable of mediating the insulin growth-promoting effect in endometrium); 3) similar results were obtained when studying hyperinsulinemia's impact on the course of breast and prostate cancer (Goodwin et al 2002;Lehrer et al 2002). As a whole, this allows us to consider the data obtained to be regular and reproducible.…”
Section: Resultssupporting
confidence: 51%
“…Significant positive correlations were found only between fasting insulin indices and cancer spread in the patients with highly and moderately differentiated endometrial adenocarcinomas which, as mentioned earlier, are mainly type I (Table 3). The association noted is most probably not an accidental coincidence due to the following reasons: 1) quite solid statistical significance was reached regarding the correlation analysis results; 2) the association of hyperinsulinemia with cancer progression is biologically explainable (there are several mechanisms capable of mediating the insulin growth-promoting effect in endometrium); 3) similar results were obtained when studying hyperinsulinemia's impact on the course of breast and prostate cancer (Goodwin et al 2002;Lehrer et al 2002). As a whole, this allows us to consider the data obtained to be regular and reproducible.…”
Section: Resultssupporting
confidence: 51%
“…The low plasma glucose levels will lead to lower insulin secretion as compared with high glucose levels, which may be protective to prostate cancer, as insulin per se is mitogenic and it has a growth-stimulatory effect on prostate cancer [141]. This hypothesis would be supported by other studies showing a positive association between high serum insulin levels and increased prostate cancer risk [141,142,143]. It does not, however, explain the fact that an increased risk of prostate cancer in JAZF1 variants has also been suggested [138].…”
Section: Non-hypothesis-directed Nutrigenetics: Examples Of Nutrient-supporting
confidence: 74%
“…Reports have also been published suggesting a relationship between insulin resistance/hyperinsulinemia and both colorectal and prostate cancer. As with breast cancer, the evidence consists of reports that both cancers are more likely to occur in individuals who are overweight 11 and/or have type 2DM, as well as the presence of higher plasma insulin concentrations in patients with colorectal or prostate cancer [60][61][62][63][64][65][66][67][68].…”
Section: E Certain Forms Of Cancermentioning
confidence: 99%