Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Jakobsdottir, S; Nieuwpoort, I. Caroline van; Schaap, Laura A.; Schoor, Natasja M. van; Lips, Paul; Drent, Madeleine L.

doi:10.1111/j.1365-2265.2009.03747.x

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…Overall, there is strong evidence that ACE inhibitors lead to an increase in circulating IGF1 levels. We found significantly higher IGF1 values in men than in women in accordance with a recent publication (24). The reason for this difference is not known but testosterone and also physical activity are known to affect IGFI (24,25).…”

Section: Discussionsupporting

confidence: 79%

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

Chisalita¹,

Dahlström²,

Arnqvist³

et al. 2011

European Journal of Endocrinology

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Objective: There are conflicting results regarding the association of circulating IGF1 with cardiovascular (CV) morbidity and mortality. We assessed the relationship between IGF1 levels and heart failure (HF), ischemic heart disease (IHD), and CV mortality in an elderly population taking into account the possible impact of angiotensin converting enzyme (ACE) inhibitors. Design and methods: A total of 851 persons aged 66-81 years, in a rural Swedish municipality, were subjected to medical history, clinical examination, electrocardiography, echocardiography, and fasting plasma samples. They were then followed for 8 years. Results and conclusion: Patients on ACE inhibitors had higher IGF1 levels compared with those without ACE inhibitors. In patients on ACE inhibitors, higher IGF1 values were found in patients with an ejection fraction (EF) !40% compared with EF R40%, in patients with higher proBNP levels in quartile 4 vs 1, and in patients with IHD when compared to those without ACE inhibitors (P!0.001). In patients without ACE inhibitors, no relationship was found between IGF1 levels and HF or IHD. In multivariate regression, only ACE inhibitors, ECG changes characteristic for IHD, and gender had a significant impact on IGF1. Patients with higher IGF1 levels in quintiles 4 and 5 compared to quintiles 1 and 2 had a 50% higher risk for CV death (PZ0.03). This was significant after adjustment for wellknown CV risk factors and ACE inhibitors (PZ0.03). Conclusions: Our results show that treatment with ACE inhibitors in an elderly population is associated with increased IGF1 levels, especially in patients with impaired cardiac function or IHD. High IGF1 levels tend to be associated with an increased risk for CV mortality.

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Section: Discussionsupporting

confidence: 79%

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

Chisalita¹,

Dahlström²,

Arnqvist³

et al. 2011

European Journal of Endocrinology

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“…However, in contrast to recently published studies, we found no significant gender differences in IGF1 levels in the middle-aged-and oldest-old subjects (37,38). Gender differences were present for IGFBP3 levels consistent with the findings of previous studies (39).…”

Section: Discussioncontrasting

confidence: 57%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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Objective: In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged-and oldest-old subjects. Design: Cross-sectional analysis in two different cohorts composed of middle-aged-(nZ672, mean 63.9G6.7 years) and oldest-old subjects (nZ272, all 89 years). Methods: Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately. Results: IGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged-and oldest-old women (both, P!0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldestold men (PZ0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (PZ0.002). Conclusion: The significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

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“…Given the anabolic properties of IGF-I and previous reports of positive associations with IGF-I with muscle mass [19], thigh muscle area and density [20], these findings might appear counterintuitive. However, other studies have not observed significant associations between IGF-I and fat-free mass [10,22,23]. While a negative association between IGF-I and body fat has been reported in previous reports among older subjects with greater fat content [11,21,23,24], these associations have been diminished after adjusting for age.…”

Section: Discussionmentioning

confidence: 92%

Circulating IGF-I is associated with fitness and health outcomes in a population of 846 young healthy men

Nindl

Santtila

Vaara

et al. 2011

Growth Hormone & IGF Research

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Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Cited by 8 publications

References 33 publications

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Circulating IGF-I is associated with fitness and health outcomes in a population of 846 young healthy men

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