Serum Insulin-Like Growth Factor-I (IGF-I) in Normal Japanese Adults.

Kitano, Michie; Shimizu, Taeko; Yamazaki, Yuko; Umezu, Yoshie; Arakawa, Yukiko; Daimon, Yukako

doi:10.1507/endocrj.42.767

Cited by 13 publications

(7 citation statements)

References 8 publications

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“…This would be another indication that the growth factors are involved in pubertal growth. Our observations of the age-and gender-associated variation in levels of IGFs and IGFBP-3 were consistent with the findings in the literature (21,(25)(26)(27)(28)(29)(30)(31). However, there were few publications describing the normal reference ranges of IGFBP-2, IGFBP-6, and ALS (32)(33)(34).…”

Section: Discussionsupporting

confidence: 91%

Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation

Mistry

Nicar

et al. 1999

J. Clin. Lab. Anal.

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Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks of certain types of cancer. To facilitate the application, we reported a large collection of reference ranges of IGFs and IGFBPs in normal population and evaluations of these molecules in serum and plasma as well as the impact of freeze-thaw cycles on the measurement. IGF-I, IGFBP-3 andALS showed a similar pattern of change associated with age. Levels of these molecules were low at birth and increased with age through puberty. After puberty the levels declined slowly with age. Overall, IGF-I, IGFBP-3 and ALS were slightly higher in females than in males. Free IGF-I accounted for about 1% of the total IGF-I and its variation with age was similar to total IGF-I. IGF-II levels were also increased with age from birth to puberty, but became stable after puberty. There was little difference in IGF-II levels between genders. IGFBP-2 levels declined with age from birth to puberty. Levels of IGFBP-6 in contrast were increased with age. These IGF binding proteins were higher in males than in females. IGFs, IGFBP-3 and ALS were 5-10% higher in serum than in plasma. IGFBP-2 and IGFBP-6 differed substantially between serum and plasma. Freeze-thaw treatment up to five cycles had little impact on plasma levels of IGFs and IGFBP-3. Our observations suggest that levels of IGFs and their binding proteins are varied with age, gender, and types of specimen and that these variations need to be taken into consideration when IGFs and their binding proteins are utilized in clinic and research.

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Section: Discussionsupporting

confidence: 91%

Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation

Mistry

Nicar

et al. 1999

J. Clin. Lab. Anal.

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“…, 1995; Nystrom et al. , 1997), but in contrast to those presented by others (Kitano et al. , 1995; Yamamoto et al.…”

Section: Discussioncontrasting

confidence: 69%

IGF‐I in a normal population: relation to psychosocial factors

Undén¹,

Elofsson²,

Knox³

et al. 2002

Clinical Endocrinology

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In a randomly selected (nondisease) population, IGF-I concentrations show a consistent decrease with age in both men and women, accompanied by different association patterns relevant to disease risk. Levels are related to psychosocial parameters in the younger age group and metabolic impairment associated with increased cardiovascular risk in the older age groups. We speculate on the relative roles of age and cohort differences in rearing conditions in determining these differences.

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“…Her IGF-1 level was 333 ng/mL. GH secretion declines steadily with aging and is accompanied by a steady decrease in IGF-1 [34][35][36]. The gradual decline in the level of these hormones during adulthood is accompanied by aging-related changes in body composition and physical and psychological functions, an increase in adiposity, a reduction in muscle mass and strength, reduced exercise tolerance, and decreased physical and cognitive performance [34,37,38].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Elderly Acromegalics

et al. 2008

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Abstract. We assessed the incidence of elderly patients in Japanese acromegalics and the characteristics of their clinical presentation. We also evaluated the safety and efficacy of transsphenoidal surgery (TSS) in this patient group. During the 28-year period from 1980 to 2007 we treated 290 patients with acromegaly at our hospitals. Of these, 9 (3.1%) were elderly, i.e. 70 years old or older. They comprised 0.7% of acromegalics treated during the first-and 4.5% of patients with acromegaly treated during the 2nd 14-year period. Before treatment, all manifested abnormal glucose tolerance; 6 had diabetes mellitus (DM), 6 presented with hypertension, and 2 had cardiovascular disease, malignant neoplasms, or hyperlipidemia. Of the 7 elderly acromegalics who underwent TSS none manifested surgical morbidity or new pituitary hormone deficiencies. Postoperatively, the nadir growth hormone (GH) level at the oral glucose tolerance test (OGTT) was under 1.0 ng/mL in 5 patients, insulin-like growth factor (IGF-1) levels normalized in 4. Glucose tolerance improved in all operated patients. Only 1 of 6 patients with preoperatively diagnosed DM continued to manifest DM post-treatment, anti-hypertensive drugs could be tapered in 3 of patients with preoperative hypertension. In conclusion, we found that there was a high incidence of abnormal glucose tolerance and hypertension in elderly acromegalics, that surgical treatment was effective and safe in this population, and that it was useful for the control of co-morbidities.

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Serum Insulin-Like Growth Factor-I (IGF-I) in Normal Japanese Adults.

Cited by 13 publications

References 8 publications

Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation

Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation

IGF‐I in a normal population: relation to psychosocial factors

Treatment of Elderly Acromegalics

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