Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome

Trojan, Daria A.; Collet, Jean Paul; Pollak, Michael; Shapiro, Stan; Jubelt, B.; Miller, Robert G.; Agre, James C.; Munsat, Theodore L.; Hollander, Dave; Tandan, Rup; Robinson, Ann; Finch, Lois; Ducruet, Thiérry; Cashman, Neil R.

doi:10.1016/s0022-510x(00)00459-7

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…At present, management of patients is primarily symptomatic and supportive since none of the pharmacological agents tested has shown substantial clinical benefits [10,42,49,[53][54][55][56][57][58][59].…”

Section: Treatmentmentioning

confidence: 99%

Postpolio syndrome: a challenge to the health-care system

2005

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Section: Treatmentmentioning

confidence: 99%

Postpolio syndrome: a challenge to the health-care system

2005

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“…38 Serum creatine kinase levels were mildly increased in prior-polio patients. 40,42 There was no correlation between creatine kinase levels and current symptoms, although there was a significant positive correlation between voluntary elbow flexor strength and creatine kinase levels.…”

Section: Discussionmentioning

confidence: 95%

“…It remains to be determined whether decreased levels of IGF-1 are linked to impairment in voluntary activation in these patients and whether the maximal level of voluntary activation improves when IGF-1 levels are increased. 31,33,35,38 Some investigators 40,42 have found increased serum creatine kinase levels in postpolio patients. Therefore, we hypothesized that IGF-1 and creatine kinase may predict impaired voluntary activation and impaired endurance, respectively.…”

mentioning

confidence: 99%

Prediction of voluntary activation, strength and endurance of elbow flexors in postpolio patients

et al. 2004

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To examine the long-term effects of polio, maximal voluntary strength and voluntary activation of elbow flexor muscles of 177 patients from a postpolio clinic were investigated using twitch interpolation. Muscle endurance was studied in 142 patients during 45 min of submaximal exercise, and predictors of impaired muscle performance were investigated. Twenty-nine of 177 patients (16.4%) had impaired voluntary drive to their elbow flexor muscles, but only 16 (9.0%) had markedly reduced elbow flexor strength, despite 74 (41.8%) reporting they were initially affected in their tested limb and 172 (97.2%) patients reporting new generalized symptoms. Seven patients had impaired muscle endurance in the tests of strength and voluntary drive. During the submaximal exercise, 16 patients (11.3%) had impaired peripheral muscle endurance with normal voluntary activation. These results confirm a low incidence of impaired upper-limb muscle performance in postpolio patients, despite many patients having subjective symptoms consistent with postpolio syndrome. There was an increased relative risk for impaired muscle function in those patients with a subjective decrease in strength in the tested limb, a recent decline in activities of daily living in their tested limb, and who used orthotic devices in their tested limb. Monitoring of function in prior-polio patients with impaired muscle performance may be useful, particularly when combined with investigation of other potential contributory factors to the functional impairment.

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“…In a small randomized study of 33 obese postmenopausal women on a diet and exercise program, Thompson et al found that women treated with IGF-I with or without growth hormone, but not growth hormone alone or placebo, had significant improvements in depression and anxiety scores (18). In contrast, Trojan et al did not observe any associations between IGF-I levels and QOL measurements among 112 patients with post -polio syndrome (19). The mechanism of the potential influence of the IGF proteins on QOL is unclear, although the IGF/growth hormone axis has been correlated with improved organ functions, such as those of the brain (20) and heart (21,22) as well as bone density (23), which may lead to enhanced physical and psychological wellbeing.…”

Section: Introductionmentioning

confidence: 99%

Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer

Meyerhardt

Sargent

Goldberg

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objective: Predictors of quality of life (QOL) in patients with metastatic colorectal cancer are lacking. The insulin-like growth factor (IGF) family of proteins is associated with QOL in noncancer populations. We sought to study whether these proteins are associated with QOL in patients with colorectal cancer. Method: We used a cohort of 526 patients with metastatic colorectal cancer treated with combination chemotherapy. Plasma samples of IGF-I, IGF-II, IGF binding protein-3, and C-peptide were collected before initiation of chemotherapy. QOL was measured by the uniscale instrument and the Symptom Distress Scale at baseline and throughout treatment. Results: Baseline plasma levels of IGF-I and IGF-II before initiation of chemotherapy were significantly associated with several important baseline QOL measures in patients with metastatic colorectal cancer. Patients with lower levels of IGF-I reported increased distress with regard to appearance, appetite, cough, and nausea intensity after adjustment for potential confounders. Similarly, decreased levels of IGF-II were predictive of worse quality related to appearance, appetite, fatigue, nausea frequency and intensity, pain frequency, and composite Symptom Distress Scale score. IGF binding protein-3 and C-peptide were not predictive of baseline QOL. Baseline biomarkers were not associated with subsequent changes in QOL during treatment. Higher body mass index was significantly associated with superior baseline QOL in several areas; nonetheless, the association of IGF-I and IGF-II with baseline QOL measures remained significant even after controlling for baseline body mass index. Conclusion: Baseline plasma IGF-I and IGF-II are significantly associated with symptom distress. Whether this association is simply reflective of patient nutritional status and/or disease burden or represents an independent biological effect of IGFs on QOL remains uncertain. Nonetheless, these data suggest that molecular biomarkers may be useful predictors of QOL in cancer patients. (Cancer Epidemiol Biomarkers Prev 2005;14(6):1402 -10)

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Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome

Cited by 15 publications

References 36 publications

Postpolio syndrome: a challenge to the health-care system

Postpolio syndrome: a challenge to the health-care system

Prediction of voluntary activation, strength and endurance of elbow flexors in postpolio patients

Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer

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