Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis

Abstract

Background-Proinflammatory and antiinflammatory cytokines are involved in the pathogenesis of acute pancreatitis. Aims-To measure the serial serum levels of interleukin 10 and interleukin 11 in patients with acute pancreatitis and analyse the relation of these antiinflammatory cytokines to disease severity. Methods-In 50 patients with acute pancreatitis, the serum concentrations of interleukin 10 and interleukin 11 were determined on days one, two, three, four, and seven after admission. Serum C reactive protein levels were evaluated on days one and two. Severity of pancreatitis was determined according to the Atlanta criteria. Results-Serum concentrations of interleukin 10 on days one to seven were significantly higher in patients with severe pancreatitis than in those with mild pancreatitis. Patients with severe attacks had significantly elevated serum interleukin 11 concentrations on days two to four compared with those with mild attacks, but not on days one and seven. With cut oV levels of 30 pg/ml for interleukin 10, 10.5 pg/ml for interleukin 11, and 115 mg/l for C reactive protein, the accuracy rates for detecting severe pancreatitis were 84%, 64%, and 78% respectively on day one and 82%, 74%, and 84% respectively on day two. Conclusions-Serum interleukin 10 and interleukin 11 concentrations reflect the severity of acute pancreatitis. Interleukin 10 is a useful variable for early prediction of the prognosis of acute pancreatitis. (Gut 1999;45:895-899)

Correlation between ranson score and red cell distribution width (RDW) in acute pancreatitis

“…Though 1 study reported sensitivity of 67% and specificity of 100% with IL-10 for prediction of severity on first day of AP, [24] other studies have stated less reliable results compared with IL-6 and IL-8. [19] Tumor necrosis factor alpha (TNF-α), which is produced primarily by macrophages, is a cytokine that stimulates acute phase reaction.…”

Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats

“…The elevated IL-6 levels in AP may serve as markers of severity of pancreatitis (Galloway and Kingsnorth, 1994), as well as being associated with the occurrence of remote organ complications (Suzuki et al, 2000). Plasma IL-10 levels have been reported to correlate with the severity of pancreatitis and could also be used as an indicator of severity (Chen et al, 1999). The magnitude of the anti-inflammatory response in patients with AP have been demonstrated to predict the clinical outcome (Mentula et al, 2004).…”

Cost-effectiveness analysis of early veno-venous hemofiltration for severe acute pancreatitis in China

“…This results in an imbalance between pro-and anti-inflammatory cytokines, resulting in the development of SIRS. Some mediators, such as TNF-alpha, phospholipase, and kinin, are increased greatly in animal models of SAP [9] , and some studies have shown that there is a significant correlation between the serum levels of IL-1-beta, IL-6, IL-8, IL-10 and IL-11 and the severity of acute pancreatitis [24][25][26][27] . Animal studies have shown that early blockade of the cytokine cascade at the level of the IL-1 receptor significantly decreases the severity of pancreatitis and intrinsic pancreatic damage, as well as the mortality from SAP [28,29] .…”