Serum interleukin-18

Dong, Guangsu; Wang, Fei; Xu, Liang; Zhu, Min; Zhang, Bin; Wang, Bin

doi:10.1097/md.0000000000015529

Cited by 8 publications

(2 citation statements)

References 30 publications

(32 reference statements)

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“…Based on the ROC curve, the sensitivity and specificity of IL-18 as a predictor of prognosis at a cutoff of 509.5 pg/mL were 88% and 82%, respectively, and the area under the curve (RUC) was 0.84 (P <.05). In summary, our finding suggested that serum IL-18 might serve as a prognostic biomarker in ARDS [29] . Makabe et al [34] has reported that IL-18 expression level in the serum was significantly higher in the non-survivors of ARDS patients.…”

Section: Discussionmentioning

confidence: 54%

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Cytokine concentrations in bronchoalveolar lavage fluid (BALF) from children with severe community-acquired pneumonia (SCAP) from Shanghai

Yin

Lü

Ding

et al. 2021

Preprint

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Background: It has been well known that overreaction of host immune systems plays a critical role in severe community-acquired pneumonia (SCAP). However, few of previous studies focused on the association between cytokine concentrations in bronchoalveolar lavage fluid (BALF) and SCAP. Object: We examined cytokine concentrations in BALF from children with SCAP and explored predictive value of cytokine concentrations for SCAP. Method: It was a retrospective study. A total of 100 children with SCAP who underwent parallel bronchoalveolar lavage between July 2017 and June 2019 were enrolled. 100 patients with mild community-acquired pneumonia (MCAP) who were admitted to the hospital were matched based on age and sex during the same time period . Basic clinical information were collected. Flow cytometry was used to determine the cytokine concentrations in BALF. Receiver operating characteristic curve was used to analyze their predictive value for SCAP. Result: A total of 106 males and 94 females were included in this study. The results showed that the CRP, PCT, ESR, LDH, and D-dimer were significantly increased in the SCAP group. The SCAP patients also had longer fever duration, hospitalization stays, and higher hospitalization costs. The IL-5，IL-17A，IL-18，and TnF-α in BALF of SCAP group were significantly higher than those in MCAP group. ROC curve analysis demonstrated AUC of those cytokines were all among 0.5~0.7. Conclusion: The IL-5，IL-17A，IL-18，and TnF-α in BALF of children with SCAP group were highe. However, the efficacy of those cytokines in the clinical diagnosis of SCAP is not excellent to be used as a predictor.

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Section: Discussionmentioning

confidence: 54%

“…Other studies supported that in children elevated serum IL-5 levels have also been found in wheezing caused by a rhinovirus or respiratory syncytial virus infection [26] . IL-17A,IL-18 and TnF-α are pro-inflammatory cytokines [27,28,29] .…”

Section: Discussionmentioning

confidence: 99%

Cytokine concentrations in bronchoalveolar lavage fluid (BALF) from children with severe community-acquired pneumonia (SCAP) from Shanghai

Yin

Lü

Ding

et al. 2021

Preprint

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The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Meantime, cytokines recognize as crucial components in guiding the appropriate immune pathways in the restraining and eradication of the virus. Moreover, SARS-CoV-2 can induce uncontrolled inflammatory responses characterized by hyper-inflammatory cytokine production, which causes cytokine storm and acute respiratory distress syndrome (ARDS). As excessive inflammatory responses are contributed to the severe stage of the COVID-19 disease, therefore, the pro-inflammatory cytokines are regarded as the Achilles heel during COVID-19 infection. Among these cytokines, interleukin (IL-) 1 family cytokines (IL-1, IL-18, IL-33, IL-36, IL-37, and IL-38) appear to have a strong inflammatory role in severe COVID-19. Hence, understanding the underlying inflammatory mechanism of these cytokines during infection is critical for reducing the symptoms and severity of the disease. Here, the possible mechanisms and pathways involved in inflammatory immune responses are discussed.

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