Serum interleukin 6 and acute urinary retention in elderly men with benign prostatic hyperplasia in China: a cross-sectional study

Wu, Di; Shi, Zhanqun; Ding, Xu; Wu, Yu; Qian, Subo; Qi, Jun

doi:10.21037/tau-20-914

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…Cross-sectional studies of sIL-6 and sIL-8 in 256 and 245 BPH patients were conducted using univariate and multivariate logistic regression analyses. The results revealed a positive correlation between sIL-6 and sIL-8 levels in the AUR group and AUR [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

The role of inflammatory processes and zinc levels in prostatic enlargement among Iraqi samples

Sameen,

Shabeeb,

Rashied

2023

JMedLife

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This study aimed to investigate the role of inflammatory processes in benign prostatic enlargement among men with elevated prostate-specific antigen (PSA) levels without a history of prostatic disease. Additionally, we aimed to examine the influence of serum zinc levels on prostate volume. We investigated the associations between systemic inflammatory markers, serum PSA, and serum zinc levels in 48 men without a history of prostatic disease, aged between 60-72 years, and 30 healthy men in the same age range. Data collection occurred between 1/2/2022 to 1/10/2022. The results are presented as mean values ± standard error (SE), and statistical significance was determined at p≤0.05. The levels of sIL-8 (P: 44.295±1.002, C: 1.404±0.2562), IL-6 (P: 7.406±0.5632, C: 4.468±0.830), CRP (P: 14.765±0.565, C: 6.267±0.538), increased significantly in patients with high PSA, while zinc levels (P: 92.305±2.8235, C: 114.565±8.861) decreased in the patient group. Regarding white blood cell (WBC) parameters, patients exhibited a significant increase in WBC total count (P: 12995.00±488.47, C: 7713.333±777.778), neutrophil % (P: 69.450±1.619, C: 51.200±1.826), lymphocyte % (P: 39.50±2.024, C: 30.867±1.268), and NLR (2.013±0.105). Conversely, there were no significant differences in eosinophil % (P: 3.450±0.4558, C: 3.267±0.5297), basophil % (P: 0.300±0.105, C: 0.267±1182), or monocyte % (P: 3.450±0.4558, C: 3.267±0.5297) between the two groups. In men without known prostatic illness, increased PSA was linked to markers of systemic inflammation. The results indicate the role of inflammatory processes in increasing the size of the prostate gland, as evidenced by the increased levels of immune markers like white blood cells and interleukins, along with the influence of zinc. Future research is required to determine how these markers relate to the development and incidence of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

The role of inflammatory processes and zinc levels in prostatic enlargement among Iraqi samples

Sameen,

Shabeeb,

Rashied

2023

JMedLife

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“…Thus, a previous study has highlighted that the risk of urinary retention is tightly associated with inflammation [ 17 ]. Wu et al [ 18 ] have exhibited that the serum concentration of IL-6 was notably enhanced in patients with acute urinary retention. Our ELISA results revealed that Prostant treatment notably diminished the serum level of proinflammatory cytokines including TNF- α and IL-6 both on the first and second day after the operation.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

Luo

Jiang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Anal pain and urinary retention are the two most outstanding complications of the procedure for prolapse and hemorrhoids (PPH) surgery. This study intended to assess the clinical effect and mechanism of Prostant on urinary retention and anal pain after the PPH. Here, 30 patients received PPH surgery. The role and mechanism of Prostant in patients and mice with urinary retention and anal pain were evaluated. ANOVA tests were executed and differences between groups were regarded as statistically significant when p < 0.05 . Prostant effectively improved the urination status, lower abdomen symptoms, time to urinate and score of VAS, and the reduction of TNF-α and IL-6. Similarly, Prostant can ameliorate the outcome of urodynamics in urinary retention mice. Mechanically, Prostant reversed the urinary retention-elevated the serum level of hs-CRP and TNF-α, reduction of IL-2, imbalance of Treg/Th17, and level of JAK2 and phosphorylated STAT3. Besides, Prostant ameliorated the pain as shown by the reduction of writhing response, and the elevation of threshold of pain and degree of swelling. Moreover, Prostant antagonized the pain-induced dysregulation of Treg/Th17. Therefore, Prostant can treat patients and mice with anal pain and urinary retention by modulating the balance of Th17/Treg to regulate the secretion and production of inflammatory factors. We hope our results can establish a scientific treatment approach for solving anal pain and urinary retention after PPH surgery of mixed hemorrhoids.

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“…Wu et al reported in their cross-sectional studies that high sIL-6 and sIL-8 levels in BPH patients were considered to be significantly correlated with acute urinary retention (OR = 9.67/ 8.85). 52,53 Smith et al reported that IL-8 and its receptors directly promoted the growth of prostate epithelial cells through the IL-8 axis in BPH patients. 54 Arivazhagan et al reported that serum IL-17, which is a T-lymphocyte-derived proinflammatory cytokine, levels in BPH patients were significantly higher than those of a normal control group.…”

Section: Inflammatory Cytokinesmentioning

confidence: 99%

“…Wu et al. reported in their cross‐sectional studies that high sIL‐6 and sIL‐8 levels in BPH patients were considered to be significantly correlated with acute urinary retention (OR = 9.67/8.85) 52,53 . Smith et al.…”

Section: Intrinsic Factorsmentioning

confidence: 99%

Intrinsic and extrinsic factors causing hyperplasia of the prostate

Kyoda,

Shibamori,

Shindo

et al. 2024

Int J of Urology

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Prostatic hyperplasia is very common in elderly men and is a typical disease that reduces quality of life. Histologically, hyperplasia of the prostate gland causes obstruction at the bladder outlet, resulting in symptoms such as a weak urine stream. Various factors have been considered to cause histological enlargement of the prostate, but the underlying cause is still unknown. The factors that cause prostate hyperplasia can be broadly classified into intrinsic and extrinsic ones. Extrinsic factors include things that we directly come into contact with such as bacteria and food. On the other hand, intrinsic factors are those that cause changes in functions originally provided in the body due to some cause, including extrinsic factors, such as chronic inflammation and an imbalance of sex hormones. A large number of reports have been made to date regarding the etiology of prostatic hyperplasia, although they have not yet clarified the fundamental cause(s). The various factors currently known should be outlined for future research. Should it be possible to prevent this highly prevalent prostatic hyperplasia which is mainly cause of dcreasing quality of life, there is no doubt that it would be a huge contribution to humanity.

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Serum interleukin 6 and acute urinary retention in elderly men with benign prostatic hyperplasia in China: a cross-sectional study

Cited by 7 publications

References 39 publications

The role of inflammatory processes and zinc levels in prostatic enlargement among Iraqi samples

The role of inflammatory processes and zinc levels in prostatic enlargement among Iraqi samples

The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

Intrinsic and extrinsic factors causing hyperplasia of the prostate

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