Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: A cohort study

Zhang, Jing; Yang, Hao; Ou, Weihua; Ming, Fei; Liang, Gang; Qian, Yu; Cai, Qian; Dong, Shuang-Lin; Hu, Sheng; Wang, Weida; Wei, Shaozhong

doi:10.21203/rs.3.rs-47937/v1

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In our study D-dimers levels were found to be significantly increased in cases than in controls indicating increased coagulopathy. Also, significantly increased levels of IL6 found in our study among cases further confirms proinflammatory state in Covid-19 infection which is associated with over activated complement system [ 39 ].…”

Section: Discussionsupporting

confidence: 77%

Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases

et al. 2022

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Introduction Detecting low viral load has been a challenge in this pandemic, which has led to its escalated transmission. Complement activation has been implicated in pathogenesis of Covid-19 infection. Thus, evaluation of complement activation in suspected Covid-19 infection may help to detect infection and limit false negative cases thus limiting transmission of infection. We speculate that measuring C4b, produced from an activated complement system due to the presence of Covid-19 may help in its detection, even when the viral titers are low. Methods Plasma C4b levels of symptomatic RT-PCR positive patients (cases, n = 40); symptomatic RT-PCR negative patients (n = 35) and asymptomatic RT-PCR negative controls (n = 40) were evaluated. Plasma C5b-9, IL-6, D-dimer and C1-Inhibitor (C1-INH) were also measured in cases and controls. ELISA kits were used for all measurements. Statistical analyses were carried out using Stata, version 12 (Stata Corp., Texas, USA). Results C4b levels were found to be significantly increased in RT-PCR positive patients as compared to asymptomatic RT-PCR negative controls. RT-PCR negative but symptomatic patients still showed increased C4b levels. The significantly higher levels of C4b in cases with a cut-off value of ≥ 116 ng/ml with optimum sensitivity and specificity of 80% and 52% respectively is indicative of its possible use as an adjunct marker. Increased levels of D-dimer, IL6, along with decreased levels of C1-INH were found in cases compared to controls. Whereas, C5b-9 levels were not significantly raised in cases. Conclusions The results of our study suggests that plasma C4b may help to detect infection in false negative cases of RT-PCR that escape detection owing to low viral load. However, to confirm it a large-scale study is needed. Supplementary Information The online version contains supplementary material available at 10.1007/s12291-022-01033-z.

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Section: Discussionsupporting

confidence: 77%

Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases

et al. 2022

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The correlation between biochemical indicators in COVID-19 patients with and without Diabetes Mellitus in Basra, Iraq.

Abdulkadhim,

Mohammed,

Jebur

2023

Biomed. Pharmacol. J.

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The coronavirus disease (COVID-19) is an infectious viral illness that leads to the development of acute respiratory syndrome. It exhibits a high level of contagiousness. The aforementioned virus is accountable for an incidence of pneumonia that transpired in early December 2019 in Wuhan, situated in the People's Republic of China. The global pandemic declaration on March 11, 2020, marked a significant turning point in the world's demography, as the virus had tragically claimed the lives of over 5.3 million individuals worldwide. The emergence of the Coronavirus (COVID-19) pandemic has presented an unparalleled catastrophe, resulting in the loss of many lives via several channels including social, psychological, physical, and economic dimensions. The danger associated with the virus originates from its heightened transmissibility and extensive mutational variability, as well as its impact on several bodily systems including the circulatory, neurological, renal, hepatic, nervous, and endocrine systems. The pathogenesis of Coronavirus disease 2019 (COVID-19) is intricate, and its clinical presentation is diverse, exhibiting various imaging findings that vary based on the severity of the illness and its progression through time. A general statistical comparison was made for the biochemical markers in the patients infected with only Coronavirus and patients infected with Coronavirus and complications of diabetes mellitus compared to the control group according to gender, in order to monitor the role of different biomarkers in causing a disease, with an evaluation of the difference in their levels, and the study aimed to investigate biomarkers and study the relationship between these biomarkers for COVID-19 patients with and without Diabetes Mellitus, to provide a dynamic approach to understanding the disease to diagnosis and follow-up, so as to improve the development of patients' treatment. The study performed a representative sample of (238) participants between the ages (25-80) year, of whom (81) were in a healthy control group, (78) were infected only with Coronavirus, (79) were infected with Coronavirus and had complications of diabetes mellitus, who visited Al-Basra Teaching Hospital and Allmwanei Hospital in Al-Basra province between October 2021 and February 2022. The age average for the study population was (25-80) years. Serum and blood levels of human CBC, ESR, CRP, Ferritin, D-Dimer, IL 6, Albumin, FBS, HbA1c, Troponin, Cholesterol, Triglyceride, HDL, LDL, VLDL, Creatinine, Urea, Uric acid and GFR were measured. The results show a highly significant increase in WBcs, ESR, CRP, Ferritin, D-Dimer, IL-6, Creatinine, Urea and Uric acid. , and a highly significant decrease in lymphocyte, albumin, HDL and GFR for patients compared to the control group as a total number and the number of males and females separately, While the results of comparing biochemical markers in the patients infected with Coronavirus and who had a diabetic complication a higher significant increase than patients without diabetic complication. The study of these biomarkers provides a dynamic approach to understanding the disease to diagnosis and follow-up, so as to improve the development of patients' treatment and study the relationship between these biomarkers for COVID-19 patients with and without Diabetes Mellitus.

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Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: A cohort study

Cited by 2 publications

References 13 publications

Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases

Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases

The correlation between biochemical indicators in COVID-19 patients with and without Diabetes Mellitus in Basra, Iraq.

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